Method for preparing sucralose

A technology for sucralose and sucrose, which is applied in the preparation of sugar derivatives, chemical instruments and methods, sugar derivatives, etc., can solve problems such as hidden safety hazards, labor consumption, complicated steps, etc. The effect of simplified operation steps

Pending Publication Date: 2021-08-24
NEWTREND TECHNOLOGY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the embodiment of the present invention is to provide a method for preparing sucralose, which aims to solve the problem of certain hidden safety hazards in the traditional preparation process, and the steps are cumbersome, labor-intensive, and frequent post-processing causes a large amount of waste water and waste liquid.

Method used

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  • Method for preparing sucralose

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Experimental program
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Effect test

Embodiment 1

[0025] In the reaction heating kettle, prepare the M1 solution that is formed by heating and dissolving the thionyl chloride of the Vilsmeier reagent with the raw material sucrose until the material liquid is dissolved. The concentration of the M1 solution is 60g / L, and flows into A of the microreactor at a flow rate of 80ml / min. In the unit, in addition, the catalyst and the acid anhydride solution with a concentration of 1.0mol / L flow into the A unit of the microreactor at the flow rate of 5ml / min and 30ml / min respectively. The residence time of the reaction is 60 seconds, and the reaction temperature is controlled at 0 ℃.

[0026] After the reaction solution flows out of the A unit of the microreactor, the DMF feed liquid of the Vilsmeier reagent of the configured 300g / L concentration flows into the B unit of the microreactor simultaneously at a flow rate of 20ml / min, and the residence time of the reaction unit is For 600 seconds, the reaction temperature controlled by the ...

Embodiment 2

[0030] In the reaction heating kettle, prepare the M1 solution formed by heating and dissolving the thionyl chloride of the raw material sucrose with the Vilsmeier reagent until the material liquid is dissolved. The concentration of the M1 solution is 40g / L, and flows into A of the microreactor at a flow rate of 100ml / min. In the unit, in addition, the concentration is 2.0mol / L catalyst, acid anhydride solution flows into the A unit of the microreactor at the flow rate of 10ml / min and 10ml / min respectively, the residence time of this reaction is 300 seconds, and the reaction temperature is controlled at 10 ℃.

[0031] After the reaction solution flows out of the A unit of the microreactor, the DMF feed liquid of the Vilsmeier reagent of the configured 400g / L concentration flows into the B unit of the microreactor simultaneously at a flow rate of 40ml / min, and the residence time of the reaction unit is For 120 seconds, the reaction temperature controlled by the reaction unit wa...

Embodiment 3

[0035] In the reaction heating kettle, prepare the M1 solution formed by heating and dissolving the thionyl chloride of the raw material sucrose with the Vilsmeier reagent until the material liquid is dissolved. The concentration of the M1 solution is 40g / L, and flows into A of the microreactor at a flow rate of 100ml / min. In the unit, in addition, the concentration is 1.0mol / L catalyst, the acid anhydride solution flows into the A unit of the microreactor at the flow rate of 10ml / min and 30ml / min respectively, the residence time of this reaction is 240 seconds, and the reaction temperature is controlled at 5 ℃.

[0036]After the reaction solution flows out of the A unit of the microreactor, the DMF feed liquid of the Vilsmeier reagent of the configured 300g / L concentration flows into the B unit of the microreactor simultaneously at a flow rate of 30ml / min, and the residence time of the reaction unit is For 180 seconds, the reaction temperature controlled by the reaction unit ...

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Abstract

The invention is suitable for the production field of sucralose, and provides a method for preparing sucralose. The method comprises the following steps: taking sucrose and thionyl chloride of a Vilsmeier reagent as raw materials; carrying out acetylation reaction, chlorination reaction, alcoholysis reaction and purification to obtain sucralose; the micro-reactor is adopted as core equipment for preparation, so that reaction materials of three key reaction units of sucralose can be fully mixed, the reaction process can be accurately controlled, potential safety hazards are reduced, generation of by-products is reduced, and discharge of waste water and waste liquid is reduced. The invention has the advantages that the operation steps are simplified, the reaction time is shortened, the production cost is reduced, each reaction stage can be continuously operated, the continuity and automation of the reaction process are realized, and the invention is suitable for industrial production. The method is carried out under a closed condition, so that the contact with water, air and the like in the air is avoided, and the safety risk caused by the use of an acetyl reagent and a chlorinated reagent in the reaction tank is reduced.

Description

technical field [0001] The invention belongs to the production field of sucralose, in particular to a method for preparing sucralose. Background technique [0002] Due to the limitations of traditional sugar sweeteners and the rapid development of the sugar-free food market, sucralose, a high-quality and safe new non-sugar sweetener with high energy and low calorie value, is facing an excellent opportunity for development. Sucralose is currently one of the highest-level products in the development and research of high-intensity sweeteners in the world, with excellent performance. Its sweetness is 600 times that of sucrose, and the sweetness is pure, and the sweetness characteristic curve almost overlaps with sucrose. Sucralose is a non-nutritive strong sweetener, which is hardly absorbed in the human body and has zero calorie value. Sucralose is stable in nature and can maintain its stability during high-temperature food processing and long-term storage. Its crystalline pr...

Claims

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Application Information

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IPC IPC(8): C07H5/02C07H1/00C07H1/06B01J19/00
CPCC07H5/02C07H1/00C07H1/06B01J19/0093Y02P20/141
Inventor 万智欣王小强
Owner NEWTREND TECHNOLOGY CO LTD
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