Visual rapid detection mask for exhaled air coronavirus and preparation method of visual rapid detection mask

A coronavirus, exhaled breath technology, applied in the field of medical supplies, can solve problems such as shortage of medical resources, increased risk of cross-infection, and limited application of detection methods

Pending Publication Date: 2021-08-31
INST OF CHEM CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] At present, the detection methods for the 2019 novel coronavirus are mainly chest CT and reverse transcription polymerase chain reaction (RT-PCR). complete detection, which leads to the application of these

Method used

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  • Visual rapid detection mask for exhaled air coronavirus and preparation method of visual rapid detection mask
  • Visual rapid detection mask for exhaled air coronavirus and preparation method of visual rapid detection mask
  • Visual rapid detection mask for exhaled air coronavirus and preparation method of visual rapid detection mask

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Experimental program
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Effect test

Embodiment 1

[0054] This embodiment provides a visual rapid detection mask for exhaled coronavirus, refer to figure 1 and figure 2 , the visual rapid detection mask includes a mask main body 1, a breathing valve 2 and a test paper strip 3, and the test paper strip 3 is arranged on the breathing valve 2 for receiving the exhaled air to be tested; the test paper strip 3 includes Filter disc 31, sample pad 32, binding pad 33, color developing pad 34 and water absorbing pad 35; the sample pad 32, combining pad 33, color developing pad 34 and water absorbing pad 35 are overlapped successively, and are attached to the filter on the sheet 31; the sample pad 32 is located on the upper surface of the filter sheet 31 and has a water-absorbing coating; the upper surface of the filter sheet 31 faces the inside of the mask main body 1; the bonding pad 33 includes colloidal gold, and the Colloidal gold is coated with coronavirus N protein antibody; The chromogenic pad 34 is positioned at the lower sur...

Embodiment 2

[0057] This embodiment prepares a kind of mask for visual rapid detection of exhaled coronavirus, including:

[0058] 1 Materials and reagents

[0059] 1.1 Materials

[0060] 3M9501V masks were purchased from Beijing Yutong Hongye Technology Development Co., Ltd. Filters, sample pads, absorbent paper, binding pads, chromogenic pads, and absorbent pads were purchased from Beijing Aide Kangrui Technology Co., Ltd.

[0061] 1.2 Antibody

[0062] Anti-SARS E antibody, anti-SARS N protein antibody, and anti-SARS N protein antibody goat IgG polyclonal antibody were purchased from Abcam, UK.

[0063] 2 Experimental methods

[0064] 2.1 Preparation of water-absorbing MOF sample pads

[0065] The same volume of copper nitrate solution (4mM) and ethanolamine solution were quickly mixed and allowed to stand at room temperature for 36h. Suction filter 60 mL of the reaction solution on a nylon 66 organic phase filter membrane (0.22 μm) to obtain a light blue film material. Subsequen...

Embodiment 3

[0072] Embodiment 3 qualitative detection

[0073] Under sterile conditions, use the exhaled breath of the patient (infected with 2019 novel coronavirus) to inflate the sample pad for 0.5h, and after standing for 5min, observe the color change of the detection line and the quality control line; The stock solution of 2019-nCoV was used as the control group for comparison.

[0074] The experimental results show that the quality control lines of the gasified coronavirus stock solution group and the patient's exhaled breath group are both red, indicating that the data is valid this time. Red bands were found on the detection lines, indicating that the reagent strips of the present invention can be used for the qualitative detection of 2019 novel coronavirus.

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Abstract

The invention relates to a visual rapid detection mask for exhaled air coronavirus. The visual rapid detection mask comprises a mask main body, a breather valve and a test strip, wherein the test strip comprises a filter disc, and a sample pad, a combination pad, a color development pad and a water absorption pad which are in lap joint in sequence; the combination pad comprises colloidal gold coated with a coronavirus N protein antibody; and the color development pad is provided with a detection line and a quality control line, the detection line is coated with a coronavirus E protein antibody, and the quality control line is coated with an anti-coronavirus N protein antibody IgG. Rapid and accurate detection of the coronavirus can be achieved within 0.5-1 h when a subject wears the mask. The mask takes exhaled air as a detection object, and the exhaled air carries more viruses compared with body fluid such as sputum and saliva, so that by utilizing the mask, suspected patients which cannot be diagnosed temporarily and other people (susceptible people, old people, children and the like) which are inconvenient to go to hospitals for detection can be quickly and preliminarily diagnosed.

Description

technical field [0001] The invention relates to the technical field of medical supplies, in particular to a visual and rapid detection mask for exhaled coronavirus and a preparation method thereof. Background technique [0002] Coronaviruses are a class of pathogens that mainly cause respiratory and intestinal diseases. There are many protrusions on the surface of these viruses, like a crown, so they are named coronaviruses. Viruses of the genus Coronavirus are positive-strand single-stranded RNA viruses with an envelope (envelope), with a diameter of about 80-120 nm, and their genetic material is the largest among all RNA viruses, infecting humans, mice, pigs, cats, dogs, wolves, Chicken, cattle, and poultry vertebrates. A variant of coronavirus, SARS-CoV, is the pathogen that causes Severe Acute Respiratory Syndrome (SARS), and belongs to RNA viruses. [0003] Coronavirus was first isolated from chickens in 1937. The diameter of the virus particles is 60-200nm, with an ...

Claims

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Application Information

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IPC IPC(8): A41D13/11G01N33/543G01N33/569
CPCA41D13/11G01N33/56983G01N33/54313G01N2333/165
Inventor 王铁王杰黄川辉陈翔宇李艾琳薛振杰
Owner INST OF CHEM CHINESE ACAD OF SCI
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