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New application of gefarnate in treatment of dyslipidemia

A technology of dyslipidemia and gefarmate, which is applied in the field of medicine, can solve problems such as dyslipidemia, achieve the effects of gastric mucosal protection, control of blood lipids, and increase of plasma HDL-C levels

Active Publication Date: 2021-08-31
HARBIN MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no report about the use of gefarate in the treatment of dyslipidemia

Method used

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  • New application of gefarnate in treatment of dyslipidemia
  • New application of gefarnate in treatment of dyslipidemia
  • New application of gefarnate in treatment of dyslipidemia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] In order to explore the effect of gefarate on the blood lipid level, this example conducts a clinical study on the effect of statins on the blood lipid level of coronary heart disease complicated with hypertriglyceridemia.

[0022] The concrete scheme of clinical research of this embodiment is as follows:

[0023] This study adopted a prospective, randomized, and controlled design, and enrolled 69 patients who met the inclusion and exclusion criteria and had received statin therapy for coronary heart disease complicated with hypertriglyceridemia. All patients enrolled in this experiment were treated with moderate-intensity statins, and the types and doses of statins did not change before and after treatment. All patients took four types of statins, and the doses of different types of statins were consistent. The dosage specifications are as follows : Atorvastatin 20mg Qd, pitavastatin 2mg Qd, rosuvastatin 10mg Qd, pravastatin 40mg Qd.

[0024] According to the random s...

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PUM

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Abstract

The invention relates to a novel application of gefarnate in treatment of dyslipidemia, and belongs to the technical field of medicines. Clinical tests prove that the gefarnate can effectively reduce the plasma TG level of a patient suffering from the coronary heart disease complicated with hypertriglyceridemia after statin treatment and can increase the plasma HDL-C level. Therefore, the invention provides the application of the gefarnate in preparation of a medicine for treating the dyslipidemia, and in the medicine for treating the dyslipidemia, the gefarnate is the unique active ingredient; and furthermore, the medicine for treating the dyslipidemia comprises gefarnate and a pharmaceutically acceptable carrier. The medicine for treating dyslipidemia is orally taken, 100mg of gefarnate is orally taken each time, and the medicine is orally taken three times a day. The gefarnate is used for patients with atherosclerotic cardiovascular diseases, and not only can play a role in protecting gastric mucosa, but also can play a role in controlling blood fat.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to the new application of gefarate for treating dyslipidemia. Background technique [0002] Gefate, that is, geraniol acetate of acacia, is an oral gastric mucosal protective drug, which can stabilize gastrointestinal mucosal cells by increasing the concentration of prostaglandins and hexosamines, and can promote the secretion of soluble mucus and increase visibility Thickness of the mucus, thereby increasing the barrier defense capacity of the gastric mucosa. Gefate can also expand the microcirculation of gastric mucosa, promote mucosal blood flow and metabolism, and heal ulcers. Clinically, gefarate is mainly used in the treatment of gastric and duodenal ulcers, acute and chronic gastritis and hyperacidity. [0003] Dyslipidemia is a relatively common disease, which is abnormal lipoprotein metabolism in the human body, mainly including total cholesterol TC and low-d...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/232A61P3/06A61P9/10
CPCA61K31/232A61P3/06A61P9/10
Inventor 李悦徐铭璐石静薄挽澜董增祥何美娇刘广忠
Owner HARBIN MEDICAL UNIVERSITY
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