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Composition of acetylcholin esterase inhibitor, and preparation method of composition

A composition and polymer technology, applied in the direction of drug combination, active ingredient of heterocyclic compound, pill delivery, etc., can solve the problem of poor masking effect

Pending Publication Date: 2021-09-07
SUNSHINE LAKE PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] As described above, in the method of masking a drug having an unpleasant taste, there are cases where the masking effect is poor or it is difficult to perform in the technical field, and therefore there is a need for a continuously improved method

Method used

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  • Composition of acetylcholin esterase inhibitor, and preparation method of composition
  • Composition of acetylcholin esterase inhibitor, and preparation method of composition
  • Composition of acetylcholin esterase inhibitor, and preparation method of composition

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Embodiment Construction

[0032]Based on the deficiencies of the prior art, the present invention has prepared a solid dispersion-containing donepezil composition after in-depth research and investigation, and the solid dispersion comprises donepezil or a salt thereof and a carrier material. The donepezil composition has good taste-masking effect, good mouthfeel, and has a dissolution property capable of reaching an effective therapeutic blood concentration.

[0033] The first aspect of the present invention provides a donepezil composition, the active ingredient is donepezil or a salt thereof, the donepezil composition includes a solid dispersion, and the solid dispersion includes the active ingredient and a carrier material. In some embodiments, the active ingredient is donepezil; in some embodiments, the active ingredient is donepezil hydrochloride.

[0034] In the donepezil composition, the carrier material includes a methacrylic acid polymer. After the methacrylic acid polymer and donepezil are m...

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PUM

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Abstract

The invention relates to a composition of an acetylcholin esterase inhibitor, and a preparation method of the composition, and belongs to the technical field of pharmaceutical preparations. The acetylcholin esterase inhibitor composition disclosed by the invention contains a solid dispersion comprising the acetylcholin esterase inhibitor and a taste masking carrier. The preparation method comprises the following steps of: mixing the acetylcholin esterase inhibitor with the taste masking carrier, and then, preparing the acetylcholin esterase inhibitor solid dispersion by a hot melt extrusion method or a spray drying method. The acetylcholin esterase inhibitor composition provided by the invention has a good taste masking effect, the prepared product has a good taste and stable quality, meanwhile, absorption of the medicine in the body is not influenced, and the safety and the effectiveness of the medicine are ensured. According to the preparation method, the composition with a relatively good taste masking effect can be simply obtained, and the composition can be applied to industrial production.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to a composition of an acetylcholinesterase inhibitor and a preparation method thereof. Background technique [0002] Donepezil hydrochloride (English name donepezil hydrochloride, trade name ARICEPT), chemical name 1-benzyl-4-[(5,6-dimethoxy-1-indanon-2-yl)methyl]piperidine salt Salt, the chemical structural formula is as follows: [0003] [0004] Donepezil is a kind of donepezil acid hexahydropyridine oxide, which is the second-generation specific reversible central acetylcholinesterase (AChE) inhibitor. By inhibiting AChE activity, the decomposition of acetylcholine (ACh) in the synaptic cleft is slowed down, thereby Increase the content of ACh to improve the cognitive function of Alzheimer's disease (AD) patients. [0005] Alzheimer's disease (Alzheimer disease, AD), also known as senile dementia, mainly occurs in the elderly, and the elderly are prone to have di...

Claims

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Application Information

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IPC IPC(8): A61K9/14A61K47/32A61K47/04A61K47/02A61K47/14A61K47/38A61K47/10A61K47/12A61K47/22A61K9/20A61K9/16A61K31/445A61P25/28
CPCA61K9/146A61K9/145A61K9/143A61K9/2095A61K9/0056A61K9/2027A61K9/2013A61K9/2009A61K9/2054A61K9/2031A61K9/1635A61K9/1617A61K9/1611A61K9/1652A61K9/1641A61K31/445A61P25/28
Inventor 石添香黄心游劲松黄芳芳
Owner SUNSHINE LAKE PHARM CO LTD