Stable amorphous nano-calcium carbonate and its preparation method and application
A technology of amorphous calcium carbonate and nano-calcium carbonate, which is applied in medical preparations containing active ingredients, pharmaceutical formulations, inorganic non-active ingredients, etc., can solve the problems that ACC products cannot be used, and it is difficult to prepare stable ACC products. The effect of good drug release, excellent physiological inertness, and simple preparation process
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Embodiment 1
[0047] Use a graduated cylinder to measure 40mL of methanol and add it to a 50mL reaction kettle, then put the reaction kettle into a magnetic stirrer, adjust the temperature and speed of the magnetic stirrer to 50°C and 600r / min, respectively, and add accurately weighed 500mg of Ca(OH) 2 and 10mg PVP, sealed reactor, and then filled with 0.4MPa CO 2 (Ca(OH) 2 :CO 2 : PVP molar ratio = 0.9:1:3.3*10 -5 ) carbonization reaction for 1h, the reaction kettle was depressurized, and the reaction was terminated. The resulting reaction solution at 8000rmin -1 Centrifuge for 10 minutes. After the centrifugation is completed, take the supernatant in a 100ml round-bottomed flask, and use a rotary evaporator to remove a large amount of methanol solvent. Finally, put the obtained precipitate in a vacuum drying oven and dry it at 150°C for 4 hours to obtain ACC- PvP.
Embodiment 2
[0049] Use a graduated cylinder to measure 40mL of methanol and add it to a 50mL reaction kettle, then put the reaction kettle into a magnetic stirrer, adjust the temperature and speed of the magnetic stirrer to 50°C and 600r / min, respectively, and add accurately weighed 500mg of Ca(OH) 2 and 50mg PVP, sealed reactor, and then filled with 0.4MPa CO 2 (Ca(OH) 2 :CO 2 : PVP molar ratio = 0.9:1:1.65*10 -4 ) carbonization reaction for 1h, the reaction kettle was depressurized, and the reaction was terminated. The resulting reaction solution at 8000rmin -1 Centrifuge for 10 minutes. After the centrifugation is completed, take the supernatant in a 100ml round-bottomed flask, and use a rotary evaporator to remove a large amount of methanol solvent. Finally, put the obtained precipitate in a vacuum drying oven and dry it at 150°C for 4 hours to obtain ACC- PvP.
Embodiment 3
[0051] Use a graduated cylinder to measure 40mL of methanol and add it to a 50mL reaction kettle, then put the reaction kettle into a magnetic stirrer, adjust the temperature and speed of the magnetic stirrer to 50°C and 600r / min, respectively, and add accurately weighed 500mg of Ca(OH) 2 and 100mg PVP, sealed reactor, and then filled with 0.4MPa CO 2 (Ca(OH) 2 :CO 2 : PVP molar ratio = 0.9:1:3.3*10 -4 ) carbonization reaction for 1h, the reaction kettle was depressurized, and the reaction was terminated. The resulting reaction solution at 8000rmin -1 Centrifuge for 10 minutes. After the centrifugation is completed, take the supernatant in a 100ml round-bottomed flask, and use a rotary evaporator to remove a large amount of methanol solvent. Finally, put the obtained precipitate in a vacuum drying oven and dry it at 150°C for 4 hours to obtain ACC- PvP.
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Abstract
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