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Collagen-based biocompatible polymer dressing

A biocompatible, high-molecular technology, applied in drug delivery, bandages, pharmaceutical formulations, etc., can solve the problem of low wound healing promotion, limited material bioinert, and synthetic hydrocolloid dressings that cannot provide good support for wound cell migration And other issues

Pending Publication Date: 2021-09-07
블라파르바이오테크놀로지항저우리미티드
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, also limited by the biological inertness of materials, synthetic hydrocolloid dressings cannot provide good support for wound cell migration, and their promotion effect on wound healing is much lower than that of natural biomaterials with biological activity.

Method used

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  • Collagen-based biocompatible polymer dressing

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] The preparation of embodiment 1 dressing

[0038] 10 grams of hyaluronic acid (weight average molecular weight: 400 kDa) was weighed and dissolved in 500 ml of deionized water to obtain a hyaluronic acid solution with a w / v concentration of 2.0%. Weigh 5.35 g of sodium periodate, add it into the hyaluronic acid solution, stir at room temperature in the dark for 24 hours, add 5 ml of ethylene glycol and continue stirring for 1 hour to terminate the reaction. The obtained solution was dialyzed in deionized water for five days to obtain 860 ml of oxidized hyaluronic acid solution, and the concentration of oxidized hyaluronic acid in the obtained solution was determined to be 8.6 mg / mL by solid content detection.

[0039] 10 g of collagen was weighed and dissolved in 1000 ml of 0.1 M (0.1 mol / L) acetic acid solution to obtain a collagen solution with a w / v concentration of 1.0%. Take 232 ml of the above-mentioned oxidized hyaluronic acid solution, add it dropwise to the co...

Embodiment 2

[0040] The preparation of embodiment 2 dressings

[0041] 10 grams of hyaluronic acid (weight average molecular weight: 1 MDa) was weighed and dissolved in 1000 ml of deionized water to obtain a hyaluronic acid solution with a w / v concentration of 1.0%. Weigh 5.35 g of sodium periodate, add it into the hyaluronic acid solution, stir at room temperature in the dark for 18 hours, add 5 ml of ethylene glycol and continue stirring for 1 hour to terminate the reaction. The obtained solution was dialyzed in deionized water for five days to obtain 1830 ml of oxidized hyaluronic acid solution, and the concentration of oxidized hyaluronic acid in the obtained solution was determined to be 4.7 mg / mL by solid content detection.

[0042] 10 g of collagen was weighed and dissolved in 1000 ml of 0.1 M acetic acid solution to obtain a collagen solution with a w / v concentration of 1.0%. Take 213 ml of the above oxidized hyaluronic acid solution, add it dropwise to the collagen solution, stir...

Embodiment 3

[0043] The preparation of embodiment 3 dressings

[0044] Weighed 11.9 grams of chondroitin sulfate (weight average molecular weight: 100 kDa), dissolved in 100 ml of deionized water to obtain a chondroitin sulfate solution with a w / v concentration of 11.9%. Weigh 5.35 g of sodium periodate, add it into the chondroitin sulfate solution, stir at room temperature in the dark for 10 hours, add 5 ml of ethylene glycol and continue stirring for 1 hour to terminate the reaction. The obtained solution was dialyzed in deionized water for five days to obtain 348 ml of oxidized chondroitin sulfate solution, and the concentration of oxidized chondroitin sulfate in the obtained solution was determined to be 28.7 mg / mL by solid content detection.

[0045] 10 g of collagen was weighed and dissolved in 1000 ml of 0.1 M acetic acid solution to obtain a collagen solution with a w / v concentration of 1.0%. Take 70 ml of the above oxidized chondroitin sulfate solution, add it dropwise to the col...

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Abstract

According to the invention, aiming at the chronic and difficult-to-heal wound surface, a natural polysaccharide material is subjected to oxidized modification to obtain a polysaccharide cross-linked precursor, and a composite biological material can be obtained by subjecting the polysaccharide cross-linked precursor and collagen to Schiff base condensation of an aldehyde group and an amino group under the condition that a small molecule cross-linking agent is not added, and the dressing which can be stably stored for a long time can be obtained by subjecting the material to freeze-drying and crushing. Before use, the dressing can be redissolved by using a biocompatible sterile solution, so that the liquid dressing with uniform texture can be obtained.

Description

technical field [0001] The invention belongs to the fields of biomedicine and medical cosmetology, and in particular relates to an anti-oxidation biocompatible polymer dressing and the application of the dressing in the fields of biomedicine and medical cosmetology. Background technique [0002] In the past few decades, biocompatible polymers have become a research hotspot and made great progress in the fields of biomedicine and medical cosmetology. Several representative biocompatible polymers have played a key role in the material basis. . [0003] Collagen is the main structural protein in the extracellular matrix of various connective tissues in the human body. As the main component of connective tissue, it is the most abundant protein in mammals, accounting for 25% to 35% of the protein content of the whole body. Collagen is composed of amino acids bound together to form a triple helix-like fibril structure. It is most commonly found in connective tissues such as car...

Claims

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Application Information

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IPC IPC(8): A61L26/00
CPCA61L26/0052A61L26/0061A61L26/009A61L26/008A61L2400/06C08L89/00C08L5/08C08L1/286
Inventor 王文新阿斯根石明生徐倩杨茂伟薛秀生徐勇猛
Owner 블라파르바이오테크놀로지항저우리미티드
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