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Yeast products for use as prebiotics and compositions comprising same

A technology of prebiotic agents and compositions, which is applied in the field of compositions containing it, and can solve problems such as ignoring the potential effects of prebiotics

Pending Publication Date: 2021-09-07
LESAFFRE & CIE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because of this narrow definition, many preliminary studies of the prebiotic effects of novel fibers have taken a targeted approach to these two groups, thereby ignoring the potential effects of prebiotics on a large number of other gut microbes

Method used

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  • Yeast products for use as prebiotics and compositions comprising same
  • Yeast products for use as prebiotics and compositions comprising same
  • Yeast products for use as prebiotics and compositions comprising same

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0052] Preparation of the yeast product may include drying steps such as spray drying, vacuum drying, fluid bed drying, drum drying and / or freeze drying.

[0053] In some embodiments, the yeast product is preferably free of yeast cell membranes, yeast cytoplasm and cellular compartments, derivatives thereof, or mixtures thereof.

[0054] In some embodiments, the yeast product is not yeast extract, and does not contain such yeast extract. Yeast extract is a soluble fraction obtained directly by subjecting whole yeast cells to a disruptive treatment such as biochemical and / or mechanical treatment.

[0055] In some embodiments, the yeast product is not live whole yeast, such as instant dry yeast or active dry yeast.

[0056] Preferably, the yeast product comprises dextran.

[0057] The yeast product, in particular the soluble sub-fraction described herein, may have from 15% to 50%, preferably from 20% to 40%, more preferably from 20% to 30% beta-glucan by weight on a dry matter...

Embodiment 1

[0089] Example 1 – In vitro assessment of the prebiotic potential of yeast cell wall fractions

[0090] summary – In addition there are On the basic medium of Wall Basic, from donor stratification according to enterotype (Arumugam M et al. (2011) Enterotypes of the human gut microbiome. Nature 474 (7353): 666–666; Costea PI, et al. ) Enterotypes in the landscape of gut microbial community composition. Nat Microbiol 3(1):8–16.), the enrichment of microorganisms from six representative microbiota was studied in a representative set of donors. Using strict anaerobic culture techniques, supplemented with Wall Basic's medium is selectively enriched with diluted fecal slurries. Incubation was performed for 48 hours to allow growth on complex substrates. Changes in metabolites and microbiome composition after 48 h of enrichment were analyzed and compared to non-selective enrichment and non-supplemented minimal media to identify functional groups that predicted responses to t...

Embodiment 2

[0112] Prebiotics -Two materials were tested, Agent #1; and Agent #2. According to the method disclosed in French application FR 3080521 A1 (1853748) filed on April 27, 2018, and its related PCT application WO2019 / 207111A1, both materials are soluble subfractions of yeast treatment, followed by ribonuclease and dextranase treatment. Both materials contained 34.0 wt% total glucan (including 31.0 wt% β-glucan) and 31.0 wt% mannan by mass on a dry matter basis. They have different particle sizes.

[0113] Nutrient medium - The nutrient medium is a sugar-depleted nutrient medium that contains the basal nutrients (eg, host-derived glycans such as mucins) present in the colon.

[0114] dose - The prebiotic agent was tested at an optimal dose of 5g / L and against a blank (negative control).

[0115] culture medium – As a source of colonic microbiota, freshly prepared human fecal cultures were added.

[0116] to cultivate - 48 hours incubation was performed at 37°C, shaki...

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Abstract

It is provided a yeast product for use as a prebiotic agent, and a composition comprising it. It is also provided the non-therapeutic use of the yeast product, and the composition comprising it, as a prebiotic agent. The yeast product, and the composition comprising it, stimulate the growth of bacteria of the Bacteroidetes phylum in the mammal gut microbiota.

Description

technical field [0001] The present invention belongs to the field of human and / or animal nutrition and health. In particular, the present invention relates to yeast products useful as prebiotic agents, and compositions comprising the same. It also relates to the non-therapeutic use of yeast products as prebiotics and compositions containing them. Yeast products and compositions comprising the same stimulate the growth of bacteria of the phylum Bacteroidetes in the gut microbiota of a mammal independently of the initial microbial composition of the donor and the gut type. Background technique [0002] Non-digestible oligosaccharides (NDO) resist digestion and absorption in the human small intestine, so they are fully or partially fermented in the large intestine. These carbohydrates help maintain the regularity of colon function and may contribute to human health by reducing the risk of chronic disease. Many NDOs are considered prebiotic agents. [0003] The activity of p...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L33/145A23L33/14A61K36/064A23L31/15A23C9/20A61K31/716A61P1/12
CPCC12N1/16C12N1/18A23L33/14A23C9/20A61K36/064A61P1/12A61P1/00A61P37/04A61P3/10A61P3/06A61P3/04A61P1/16C12R2001/865C12R2001/84C12R2001/72C12R2001/645A23V2002/00A23V2200/32A23V2200/3262A23V2200/328A23V2200/324A23V2200/332A23V2250/76A23C9/203A23L31/10A23L31/15A23L33/145A23L33/21A61K31/716A23L29/256A23C9/127A23V2200/3202A23V2250/5034A23V2250/5058A23L29/206
Inventor B·罗德里格斯
Owner LESAFFRE & CIE
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