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In-situ functionalized nano lignin as well as preparation method and application thereof

A nano-lignin and functionalization technology, applied in the fields of chemical materials and biomedicine, can solve problems such as limited application prospects, poor particle stability, and cumbersome processes

Active Publication Date: 2021-09-10
JINAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Although the literature reported that nano-lignin successfully reduced chloroauric acid to generate nano-gold, the particles obtained by this method were not stable.
In addition, this type needs to go through complicated steps, or prepare functional materials in another system and then blend with lignin to realize the functionalization of lignin nanoparticles. The cumbersome process limits its application prospects and Its industrial large-scale production

Method used

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  • In-situ functionalized nano lignin as well as preparation method and application thereof
  • In-situ functionalized nano lignin as well as preparation method and application thereof
  • In-situ functionalized nano lignin as well as preparation method and application thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Embodiment 1: Preparation of lignin gold nanoparticles (Au-LNPs)

[0042] Use 200 μ L of γ-valerolactone / water system (GWS) solution containing 80vol% (γ-valerolactone) GVL to dissolve 8 mg of lignin to obtain a lignin solution; HAuCl 4 After the reaction was completed, it was collected by centrifugation (10000g, 10min) to obtain gold lignin nanoparticles (Au-LNPs), and then washed twice with deionized water.

[0043] The result is as figure 1 shown. figure 1It is shown that the particle size of the obtained Au-LNPs is about 120nm, the zeta potential is -30mV, and the size remains almost unchanged after standing for six days.

[0044] In addition, the inventors respectively used tetrahydrofuran (THF), methanol, acetone, N,N-dimethylformamide, and dimethyl sulfoxide to replace (γ-valerolactone) GVL to carry out the above experiments and determine that the prepared under different solvent systems Stability of Au-LNPs. The result is as figure 2 shown.

[0045] from...

Embodiment 2

[0046] Embodiment 2: Preparation of drug-loaded lignin gold nanoparticles (Ver-Au-LNPs)

[0047] Use 200 μL of γ-valerolactone / water system (GWS) solution containing 80 vol% (γ-valerolactone) GVL to dissolve 8 mg of lignin and 0.4 mg of Ver-155008, mix well at 30 °C for 1 hour and then add dropwise 10mL containing 1mmol / L HAuCl 4 aqueous solution; subsequently, stirred gently at 30°C for 1 h, after the reaction was completed, collected by centrifugation (10000 g, 10 min) to obtain drug-loaded lignin gold nanoparticles (Ver-Au-LNPs), and then washed with deionized water for 2 Second-rate.

[0048] The result is as image 3 shown. image 3 The high-resolution TEM image and EDS element distribution map of the above show that the drug is successfully loaded on the nano-lignin, and at the same time, the gold nanoparticles are stably loaded on the nano-lignin.

Embodiment 3

[0049] Embodiment 3: Preparation of Ag-LNPs

[0050] Use 200 μ L of γ-valerolactone / water system (GWS) solution containing 80vol% (γ-valerolactone) GVL to dissolve 8 mg of lignin to obtain a lignin solution; AgNO 3 After the reaction was completed, it was collected by centrifugation (10000g, 10min) to obtain lignin silver nanoparticles (Ag-LNPs), and then washed twice with deionized water.

[0051] The particle size of the obtained nanoparticles is about 180nm, and the zeta potential is about -30mV. Figure 4 The ultraviolet-visible absorption spectrum shows that the characteristic absorption peak of nano-silver is 425nm, Figure 5 The TEM images show that lignin (LNPs) can stabilize silver nanoparticles dispersed on the surface of lignin (LNPs).

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Abstract

The invention discloses in-situ functionalized nano lignin as well as a preparation method and application thereof, and belongs to the field of chemical materials and biomedicine. The preparation method of the in-situ functionalized nano lignin comprises the following steps: dissolving lignin or a mixture of lignin and a medicine by using a gamma-valerolactone / water system solution, then dropwise adding a metal ion solution, and performing stirring and centrifuging to obtain the in-situ functionalized nano lignin. Lignin gold nanoparticles with photo-thermal conversion performance, medicine-loaded lignin gold nanoparticles and lignin silver nanoparticles with antibacterial performance can be synthesized in situ through a one-pot method by using the gamma-valerolactone / water system solution, the preparation process conditions and equipment are simple, and the adopted solvent is green, environment-friendly, non-toxic, recyclable and biodegradable. The lignin gold nanoparticles, the medicine-loaded lignin gold nanoparticles and the lignin silver nanoparticles prepared by the method have good stability.

Description

technical field [0001] The invention belongs to the fields of chemical materials and biomedicine, and in particular relates to an in-situ functionalized nano lignin and its preparation method and application. Background technique [0002] Lignin is one of the main components of plant cell walls. It is a natural polymer with phenylpropane as the basic unit and a renewable resource that is second only to cellulose and chitin in nature. However, as a by-product of the agriculture, forestry and pulp and paper industries, lignin is often discarded or has little utilization value. Among them, the pulp and paper industry produces about 50 million tons of lignin every year, but less than 2% is commercially utilized as low-value products such as dispersants, adsorbents and surfactants, and most of them are incinerated or landfilled. Serious waste of resources. And with the rise of the biofuel ethanol industry, there will be a large amount of enzymatic hydrolysis of lignin and pretr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/14A61K47/30A61K41/00A61K31/52A61K33/38A61P35/00A61P31/10
CPCA61K9/146A61K41/0052A61K31/52A61K33/38A61P35/00A61P31/10A61K2300/00
Inventor 陈理恒薛巍朱静宜施云峰罗司曼霍聪敏
Owner JINAN UNIVERSITY