Preparation method of spiramycin adipate

Abstract

The invention provides a preparation method of spiramycin adipate, and relates to the technical field of medicines. The preparation method specifically comprises the following steps that spiramycin fermentation filtrate serves as a raw material, the pH of the filtrate is adjusted, centrifugation is conducted, supernate is taken and added into n-butyl acetate, uniform stirring, mixed extraction, standing layering and organic phase collection are conducted, and spiramycin extracting solution is obtained; an adipic acid solution is into the spiramycin extracting solution, the pH value is adjusted, back extraction is conducted onthe solution, stirring, standing, and layering are conducted, and a lower phase is taken so as to obtain a back extraction solution; activated carbon is added into the back extraction liquid, and fully stirring and decoloring are conducted to obtain a decolored liquid; and drying and crystallizing the decolored solution are conducted to obtain a finished product of the spiramycin adipate. According to the spiramycin adipate prepared by the method, the finished product of the spiramycin adipate is directly prepared from the spiramycin fermentation filtrate. According to the invention, crystallization and drying links are reduced in the spiramycin preparation process, the product yield is improved, and the method has the characteristics of good product character, safe operation, energy consumption saving and waste liquid discharge reduction.

Description

technical field

[0001] The invention belongs to the technical field of medicine, and in particular relates to a preparation method of spiramycin adipate. The invention also provides a method for preparing spiramycin adipate which is suitable for industrial production. Background technique

[0002] Spiramycin, English name Spiramycin, is a multi-component macrolide antibiotic produced by S. ambofacienss. It is a white or slightly yellow powder with a slight odor; slightly hygroscopic; easily soluble in ethanol , propanol, acetone and methanol, insoluble in water. Spiramycin belongs to the 16-membered macrolide antibiotics. In actual production, the finished product of spiramycin is mainly extracted after microbial fermentation.

[0003] In the existing spiramycin extraction technology, the commonly used method is: filter the spiramycin fermentation liquid after pretreatment to obtain the spiramycin filtrate, and then add a neutral organic solvent in the spiramycin filtrate, ...