Ion guiding assisting microneedle patch system and method for delivering biological macromolecular drugs into brain

Abstract

The invention relates to an ion guiding assisting microneedle patch system and method for delivering a biological macromolecular drug into a brain. The ion guiding assisting microneedle patch system comprises an ion guiding assisting device, a delivery device, a solution system, a microneedle device and a control-fixing device, the ion guiding assisting device is electrically connected to the microneedle device, the delivery device is connected to the ion guiding assisting device and the microneedle device, the control-fixing device is used for fixing the microneedle device to a upper lip of the face and a skin part around a nose wing, various parameters of the ion guiding assisting device and the delivery device are regulated and controlled, so that the brain entering delivery efficiency of the biological macromolecular drug is improved. The ion guiding assisting microneedle patch system is applied to the upper lip of the face and the skin around the nose wing, an amino acid ion-assisted conduction technology, a hollow micro-needle technology and a cranial nerve access technology are organically combined, synergistic and complementary effect is formed, and the purpose that the biological macromolecular drug enter the brain safely and efficiently is achieved.

Description

technical field [0001] The invention relates to a brain delivery system for macromolecular drugs, in particular to an ion-assisted microneedle patch system and a delivery method for delivering biological macromolecular drugs into the brain. Background technique [0002] The blood-brain barrier is the most important bottleneck for the treatment of central diseases through peripheral administration of drugs into the brain, especially for hormones, peptides, proteins, genes or vaccines for the treatment of brain diseases. At present, drugs break through the blood-brain barrier mainly through structural or dosage form modification. [0003] The permeability of the blood-brain barrier (BBB) ​​is poor, and peripheral administration such as intravenous, intramuscular, subcutaneous and other routes cannot effectively deliver biomacromolecular drugs to the central nervous system (CNS). In addition, with the increase of the peripheral dose of biomacromolecular drugs, the systemic sid...

AI Technical Summary

Problems solved by technology

Although the olfactory pathway provides a feasible pathway for biomacromolecular drugs to enter the brain non-invasively, it is found in clinical practice that the application of this route of administration is limited by many factors, such as the skill of administration, drug molecular weight and concentration, etc., especially body position Therefore, the actual concentration of drugs entering the brain is very low, and long-term effects cannot be formed, thus limiting the popularization and application of biomacromolecular drugs entering the brain through the nasal olfactory pathway

In addition, the drug delivery device using the nasal olfactory pathway is likely to cause discomfort to the patient, especially sneezing, which leads to the inability to guarantee the dosage

[0007] At present, there is no delivery system for efficiently delivering drugs into the brain, which can overcome the problem that the existing drug delivery system cannot effectively promote the entry of biomacromolecular drugs into the brain to take effect, and achieve the purpose of efficiently delivering biomacromolecular drugs into the brain.

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