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Preparation method of high-quality cannabidiol crystal

A cannabidiol, high-quality technology, applied in the field of preparation of high-quality cannabidiol crystals, can solve problems such as less research on crystallization and purification, and achieve the effects of avoiding explosive nucleation, reducing encapsulation, and achieving high purity

Pending Publication Date: 2021-09-17
腾冲晨光云麻生物科技有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are few studies on crystallization and purification, so there is an urgent need to study a method for preparing high-quality crystals

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0024] The preparation of the mixed solvent is as follows: such as 0.2% ethanol, n-hexane mixed solvent, is to get 0.2ml ethanol and put it in the volumetric flask, then use n-hexane to make the volume to 100ml, after mixing evenly, measure the required mixed solvent.

[0025] Similarly, for 0.5% mixed solvent of ethanol and n-heptane, take 0.5ml of ethanol and put it in a 100ml volumetric flask, then use n-heptane to set the volume to 100ml, mix well and measure the required mixed solvent.

[0026] The mixed solvents of other concentrations were also prepared according to the above method, unless otherwise stated.

Embodiment 1

[0028] A method for preparing high-quality cannabidiol crystals is carried out as follows:

[0029] 1) Take 10g of cannabidiol extract with a content of more than 60%, dissolve it in 13.5ml, 0.2% ethanol, n-hexane mixed solvent at 50°C, filter, then raise the temperature to 30°C to start cooling and crystallization, and cool down at 0.1°C / min To 19°C, add seed crystals with 1% of the extract mass, grow crystals for 1h, then continue to cool down to -2°C, keep warm for 2h, filter, wash with 0°C, 0.2% ethanol, n-hexane mixed solvent, and dry at 45°C , Cannabidiol crystals can be obtained.

[0030] The cannabidiol content in the obtained crystal is 99.09%, the content yield is 77.00%, the crystal particles are evenly distributed, and the fluidity is good.

Embodiment 2

[0032] A method for preparing high-quality cannabidiol crystals is carried out as follows:

[0033] 1) Take 10g of cannabidiol extract with a content of more than 60%, dissolve it in 13.5ml, 0.5% ethanol and n-hexane mixed solvent at 50°C, filter, then raise the temperature to 30°C to start cooling and crystallization, and cool down at 0.1°C / min To 19°C, add seed crystals with 1% of the extract mass, grow crystals for 1h, then continue to cool down to -2°C, keep warm for 2h, filter, wash with 0°C, 0.5% ethanol, n-hexane mixed solvent, and dry at 47°C , Cannabidiol crystals can be obtained.

[0034] The cannabidiol content in the obtained crystal is 99.06%, the content yield is 77.50%, the crystal particles are evenly distributed, and the fluidity is good.

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PUM

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Abstract

The invention discloses a preparation method of high-quality cannabidiol crystal, which comprises the following steps of: dissolving a cannabidiol extract serving as a raw material, filtering, controlling the cooling rate of the solution, adding a crystal growing link in a metastable region, cooling to low temperature, standing, growing the crystal, filtering, washing and drying to obtain the high-quality cannabidiol crystal. The preparation method is simple, the product quality can be greatly improved, a theoretical basis is provided for industrial production of cannabidiol, and the preparation method has important significance on industrial development of cannabidiol.

Description

technical field [0001] The invention relates to the field of crystallization and purification, in particular to a method for preparing high-quality cannabidiol crystals. Background technique [0002] The active ingredients of cannabis are rich in leaves and female flowers, mainly including tetrahydrocannabinol (THC), cannabidiol (CBD), cannabinol (CBN), cannabidiol (CBDV), cannabidiolic acid (CBDA) and Tetrahydrocannabinolic acid (THCA), etc. Among these active ingredients, cannabidiol (CBD), as the main non-psychoactive ingredient of cannabis, has a certain antipsychotic effect and inhibits the occurrence of epilepsy; it has the effect of relieving pain and analgesia; it can play an anti-inflammatory effect; Anti-proliferation and pro-apoptotic effects, and interfere with tumor neovascularization and cancer cell migration, adhesion, invasion and metastasis; reduce the duration of anxiety, and help sleep. It is widely used in the field of medicine and cosmetics industry. ...

Claims

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Application Information

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IPC IPC(8): C07C39/23C07C37/84
CPCC07C39/23C07C37/84C07C2601/16Y02P20/54
Inventor 高伟赵晓俊王璞刘登帅彭静维乔宣宣
Owner 腾冲晨光云麻生物科技有限公司