Solid-phase preparation method of pracanatide
A technology for plecanatide and solid-phase preparation, which is applied in the field of solid-phase preparation of plecanatide, can solve the problems of unfavorable industrialized production, complicated operation steps, high waste liquid cost, etc., and achieves easy preparation and purification, and easy avoidance. The effect of reunion and reduction of three wastes
Active Publication Date: 2021-09-28
礼济生物医药科技南京有限公司
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Abstract
The invention discloses a novel solid-phase preparation method of pracanatide. The method comprises the following steps of: sequentially synthesizing a disulfide bond-containing fragment I and a linker [16-14] peptide resin according to the peptide sequence of a pracanatide main chain, coupling the disulfide bond-containing fragment I and the linker [16-14] peptide resin, completing a crude product of pracanatide through the following way a or way b, and purifying to finally obtain a pure product of pracanatide, wherein the way a is a way of coupling and then oxidizing and cutting to obtain the crude product of pracanatide, or the way b is a way of selectively removing a sulfydryl protecting group, oxidizing, coupling and cutting to obtain the crude product of pracanatide. The method is simple to operate, and has the advantages of fewer steps and simple process compared with the existing process; and the obtained product is high in purity and yield, easy to purify and relatively low in preparation cost, and is beneficial to industrial production.
Application Domain
Peptide preparation methodsBulk chemical production
Technology Topic
PeptidePeptide sequence +7
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