Application of total alkaloids of cynanchum komarovii in preparation of anti-inflammatory and analgesic drugs

A total alkaloid, anti-inflammatory and analgesic technology, applied in the field of biomedicine, can solve the problem that the analgesic effect of medicinal value has not been paid attention to
CN113476491APending Publication Date: 2021-10-08NINGXIA MEDICAL UNIV
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
NINGXIA MEDICAL UNIV
Publication Date
2021-10-08

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Abstract

The invention discloses application of total alkaloids of cynanchum komarovii in preparation of anti-inflammatory and analgesic drugs. The research finds that the total alkaloids of cynanchum komarovii can prolong the thermal withdrawal latency period of a mouse in a thermal stabbing pain experiment, shorten the paw licking time of the mouse in a formalin pain experiment; and prolong the pain latency period of the mouse in an acetic acid writhing experiment, and reduce the writhing frequency, thereby effectively alleviating the pain response of the mouse. In addition, the total alkaloids of cynanchum komarovii can prolong the thermal withdrawal latency period and increase the mechanical withdrawal threshold of CIA rats, which indicates that the total alkaloids of cynanchum komarovii also have a mitigative effect on chronic inflammatory pain. Meanwhile, the total alkaloids of cynanchum komarovii can remarkably inhibit expression of inflammatory factors such as GFAP, NMDAR2B, TNF-a, IL-6 and IL-17, so that the total alkaloids of cynanchum komarovii can be used as a main component of anti-inflammatory and analgesic drugs, thus providing a new way for research and development of new drugs.
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Description

technical field

[0001] The invention belongs to the technical field of biomedicine, and in particular relates to the application of total alkaloids of melon head in the preparation of anti-inflammatory and analgesic drugs. Background technique

[0002] The International Association for the Study of Pain (IASP) has revised the definition of pain: Pain is a discernible bodily experience that reflects a person's fear of a threat to his body or bodily integrity. Many clinical diseases are accompanied by pain symptoms, and the degree of pain is closely related to the degree of pain of the patient, which not only seriously affects the quality of life and work efficiency of the patient, but also causes a serious economic burden. It is reported that the annual cost of treating chronic pain in the United States It has reached 635 billion US dollars. Therefore, effective pain relief has become one of the important topics in clinical treatment and analgesic drug research.

[0003] At...

Claims

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