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Tripterygium wilfordeuphone, preparation method thereof and application of tripterygium wilfordeuphone in medicine

A kind of technology of tripterygium wilfordii and eugenone, applied in the field of pharmaceutical compounds and pharmacy

Active Publication Date: 2021-10-08
YUNNAN BIOBIAOPHA TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In the prior art, there is no report on the formula (I) compound tripterygium eugenone (wilfordeuphone) involved in the present invention and its active ingredient in the treatment of tumors , and reports that the compound has antitumor activity

Method used

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  • Tripterygium wilfordeuphone, preparation method thereof and application of tripterygium wilfordeuphone in medicine
  • Tripterygium wilfordeuphone, preparation method thereof and application of tripterygium wilfordeuphone in medicine
  • Tripterygium wilfordeuphone, preparation method thereof and application of tripterygium wilfordeuphone in medicine

Examples

Experimental program
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Effect test

Embodiment 1

[0032] This example proposes a euphorane triterpenoid compound extracted from Tripterygium wilfordii, which is a white crystal with a molecular weight of 456 and a molecular formula of C 30 h 48 o 3 , the specific structural formula is as follows:

[0033]

[0034] The compound is isolated and purified from the dried root of Tripterygium wilfordii, and the specific extraction steps are as follows:

[0035] 1) Take 14.0kg of dried root of Tripterygium wilfordii as raw material, grind it with 95% ethanol aqueous solution which is 6 times its weight, and extract it under reflux for 3 times, then concentrate under reduced pressure until it is free of alcohol to obtain 650g of extract.

[0036] 2) Dissolve the extract with a mixed solvent of chloroform and methanol (1:1), mix the sample with 2 times the amount of silica gel (1300g) after dissolving, separate with 4 times the amount of silica gel (2600g), and use petroleum ether / acetone in turn The solvent (20:1, 10:1, 6:1, 4:...

Embodiment 2

[0057] Tablet: 10 mg of the compound obtained in Example 1, 180 mg of lactose, 55 mg of starch, and 5 mg of magnesium stearate;

[0058] Preparation method: mix the compound, lactose and starch, moisten it evenly with water, sieve the wetted mixture and dry it, then sieve it, add magnesium stearate, and press the mixture into tablets, each tablet weighs 250mg, and the compound content is 10mg .

Embodiment 3

[0060] Capsules: 100 mg of the compound obtained in Example 1, 100 mg of starch, and an appropriate amount of magnesium stearate;

[0061] Preparation method: mix the compound and auxiliary agents, sieve, mix uniformly in a suitable container, and fill the obtained mixture into hard gelatin capsules.

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Abstract

The invention provides an euphane triterpene tripterygium wilfordeuphone (a compound shown as a formula I defined in the description), a method for extracting the compound from a tripterygium wilfordii plant body, a pharmaceutical composition which takes the compound shown as the formula I as an active ingredient and is used for treating and preventing tumors, and application of the compound and the pharmaceutical composition thereof in preparation of medicines for treating and preventing tumors.

Description

technical field [0001] The present invention belongs to the field of pharmaceutical compounds and pharmacy, and in particular relates to a new compound wilfordeuphone, its preparation method, a pharmaceutical composition with the compound as an active ingredient, the compound and its pharmaceutical combination The application of substances in the preparation of drugs for the treatment of tumors. Background technique [0002] Tripterygium wilfordii (Tripterygium wilfordii) is an annual vine of the genus Tripterygium in the family Celastraceae, with a plant height of 1-3 meters. Produced in Taiwan, Fujian, Jiangsu, Zhejiang, Anhui, Hubei, Hunan, Guangxi. Grows in damp places in mountain forests. Tripterygium wilfordii is a commonly used Chinese herbal medicine in traditional Chinese medicine, which has anti-inflammatory, immunosuppressive, anti-fertility, anti-tumor, antibacterial, swelling and pain-relieving effects. [0003] Tumor refers to cells under the action of tumor...

Claims

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Application Information

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IPC IPC(8): C07J9/00A61K31/575A61P35/00A61P35/02
CPCC07J9/00A61P35/00A61P35/02
Inventor 李香梅姜先俊魏国柱王飞文世珍任丽花
Owner YUNNAN BIOBIAOPHA TECH
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