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Hellgrammites extract for treating chronic renal failure as well as preparation method and application of hellgrammites extract

A technology for crawling sandworms and kidney function, which is applied in the direction of drug combination, medical raw materials derived from arthropods, urinary system diseases, etc. It can solve the problems that have not been found in the research reports of sandworms, and achieve the reduction of kidney pathological damage and kidney coefficient , the effect of reducing the amount of drinking water

Pending Publication Date: 2021-10-15
SOUTHWEST UNIVERSITY FOR NATIONALITIES
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  • Abstract
  • Description
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Problems solved by technology

Pharmacological studies have shown that sand crawlers have anti-diuretic effects, promote the reproduction of rats, enhance the fecundity of fruit flies, and increase the lifespan of fruit flies; however, no research reports on the use of sand crawlers in chronic renal failure have been found so far.

Method used

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  • Hellgrammites extract for treating chronic renal failure as well as preparation method and application of hellgrammites extract
  • Hellgrammites extract for treating chronic renal failure as well as preparation method and application of hellgrammites extract
  • Hellgrammites extract for treating chronic renal failure as well as preparation method and application of hellgrammites extract

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Embodiment 1

[0018] A kind of crawling sandworm extract for the treatment of chronic renal failure, the preparation method thereof comprises the following steps in turn:

[0019] (1) Wash the fresh sand-crawling worms with ultrapure water, drain, and freeze at -80°C;

[0020] (2) freeze-drying the frozen sand worms obtained in step (1) at a temperature of -80 °C, then adding liquid nitrogen and grinding to obtain dry powder of sand crawlers;

[0021] (3) adding equal volume of 75vt% ethanol solution to the obtained dry powder of step (2), refluxing extraction for 5 times, 2h each time, combining the extracts, freeze-drying, to obtain the extraction of sand worms for the treatment of chronic renal failure thing.

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Abstract

The invention provides a hellgrammites extract for treating chronic renal failure as well as a preparation method and application of the hellgrammites extract. The preparation method sequentially comprises the following steps: (1) washing chellgrammites with ultrapure water, performing draining, and performing cryopreserving at the temperature of-80 DEG C; (2) freeze-drying the frozen hellgrammites obtained in the step (1) at-80 DEG C, and then adding liquid nitrogen for grinding to obtain dry hellgrammites powder; and (3) adding an isopyknic 75 vt% ethanol solution into the hellgrammites dry powder obtained in the step (2), performing reflux extraction for 2-3 hours each time for 4-6 times, combining extracting solutions, and performing freeze drying to obtain the hellgrammites extract for treating the chronic renal failure. The invention also discloses the hellgrammites extract prepared by the method and application of the hellgrammites extract in preparation of medicines for treating chronic renal failure. The corydalus cornutus extract is applied to treatment of the chronic renal failure, and various symptoms caused by the chronic renal failure can be effectively treated.

Description

technical field [0001] The invention belongs to the technical field of drugs for the treatment of chronic renal failure, and in particular relates to an extract of Climbing Sandworm for the treatment of chronic renal failure and a preparation method and application thereof. Background technique [0002] Chronic renal failure (CRF) refers to the advanced stage of various primary or secondary chronic kidney diseases. Due to the progressive destruction of nephrons, the remaining nephrons cannot fully discharge metabolic wastes and maintain the stability of the internal environment. The pathological process of a series of clinical syndromes is mainly manifested as increased serum creatinine (Scr) and blood urea nitrogen (BUN) levels, polydipsia and polyuria. [0003] Sand crawling is a well-known medicinal and edible tonic in Sichuan, Yunnan and other places. It is known as "animal ginseng". Its medicinal use was first recorded in "Xichang Chinese Herbal Medicine". Large larvae...

Claims

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Application Information

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IPC IPC(8): A61K35/64A61P13/12
CPCA61K35/64A61P13/12
Inventor 任艳刘海波
Owner SOUTHWEST UNIVERSITY FOR NATIONALITIES
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