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Composite material for stent as well as preparation method and application thereof

A technology of composite materials and raw materials, applied in the fields of pharmaceutical formula, medical science, prosthesis, etc., can solve the problems of lack of ability to effectively induce tissue regeneration and difficulty in satisfying precision medicine

Active Publication Date: 2021-10-15
INST OF MEDICINE & HEALTH GUANGDONG ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, at this stage, the application of magnesium and its alloy implants is mainly used for bone internal fixation, which lacks the ability to effectively induce tissue regeneration, and it is difficult to meet the needs of precision medicine.

Method used

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  • Composite material for stent as well as preparation method and application thereof
  • Composite material for stent as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0110] In this embodiment, a composite material for a stent is prepared, and the specific process is as follows:

[0111] D1. Substrate pretreatment: use 800-grit SiC sandpaper to polish the magnesium-based material (magnesium mass content > 99%), then rinse with deionized water for 2 minutes, dehydrate with ethanol for 4 minutes, and then immediately dry in air;

[0112] D2. Electrolyte configuration: under magnetic stirring, mix 10g Na 3 PO 4 12H 2 O and 2g Ca(OH) 2 Dissolve in 500ml deionized water to obtain solution 1;

[0113] 1g Sr(OH) 2 ·8H 2 O was dissolved in 700ml deionized water to obtain solution 2;

[0114] Mix solution 1 and solution 2, and mechanically stir for 30 minutes to obtain an electrolyte;

[0115] D3. Plasma electrolytic oxidation treatment: use the stainless steel container as the cathode and connect it to the cathode of the DC power supply;

[0116] Using the electrolyte solution obtained in step D2 as the electrolyte solution, the electrolyte...

Embodiment 2

[0137] In this embodiment, a composite material for a stent is prepared, and the specific process is as follows:

[0138] D1. Substrate pretreatment: use 600-grit SiC sandpaper to polish the magnesium-based material (magnesium mass content > 99%), then rinse with deionized water for 2 minutes, dehydrate with ethanol for 4 minutes, and then immediately dry in the air;

[0139] D2. Electrolyte configuration: under magnetic stirring, mix 15g Na 3 PO 4 12H 2 O and 2g Ca(OH) 2 Dissolve in 600ml deionized water to obtain solution 1;

[0140] 5g Sr(OH) 2 ·8H 2 O was dissolved in 600ml deionized water to obtain solution 2;

[0141] Mix solution 1 and solution 2, and mechanically stir for 40 minutes to obtain an electrolyte;

[0142] D3. Plasma electrolytic oxidation treatment: use the stainless steel container as the cathode and connect it to the cathode of the DC power supply;

[0143] Using the electrolyte solution obtained in step D2 as the electrolyte solution, the electro...

Embodiment 3

[0163] In this embodiment, a composite material for a stent is prepared, and the specific process is as follows:

[0164] D1. Substrate pretreatment: use 1000-grit SiC sandpaper to polish the magnesium-based material (magnesium mass content > 99%), then rinse with deionized water for 2 minutes, dehydrate with ethanol for 4 minutes, and then immediately dry in air;

[0165] D2. Electrolyte configuration: under magnetic stirring, mix 18g Na 3 PO 4 12H 2 O and 4g Ca(OH) 2 Dissolve in 750ml deionized water to obtain solution 1;

[0166] 4g Sr(OH) 2 ·8H 2 O was dissolved in 350ml deionized water to obtain solution 2;

[0167] Mix solution 1 and solution 2, and mechanically stir for 60 minutes to obtain an electrolyte;

[0168] D3. Plasma electrolytic oxidation treatment: use the stainless steel container as the cathode and connect it to the cathode of the DC power supply;

[0169] Using the electrolyte solution obtained in step D2 as the electrolyte solution, the electrolyte ...

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Abstract

The invention discloses a composite material for a stent as well as a preparation method and application thereof, and belongs to the technical field of composite materials. The composite material for the stent comprises: a matrix, wherein the surface of the matrix is provided with a hole structure, and in the matrix, the mass content of magnesium is greater than or equal to 99%; drug-loaded calcium silicate particles that are dispersed on the matrix and comprise composite drug particles and mesoporous calcium silicate particles loaded with the composite drug particles, wherein the composite drug particles comprise a drug and a polyethylene glycol film wrapping the drug; the controlled release film that is made of alginate, and the controlled release film covers the surfaces of the matrix and the drug-loaded calcium silicate particles. Due to the fact that the composite material for the stent is loaded with the medicine, after the composite material is used for the stent, the capacity of inducing tissue regeneration can be achieved, and meanwhile the controlled release effect on the loaded medicine can be achieved.

Description

technical field [0001] The invention belongs to the technical field of composite materials, and in particular relates to a composite material for brackets and a preparation method and application thereof. Background technique [0002] There are more than 3 million patients with bone injuries every year in my country, and there is a great demand for bone repair products. Ideal bone reconstruction materials should meet the requirements of light weight, precise mechanical matching, high bioactivity, inducible autologous tissue and blood vessel remodeling, and controllable degradation. [0003] Magnesium and its alloys are clinically recognized as degradable and biocompatible metal materials. They have the advantages of low density, can promote osteogenesis, and induce bone ingrowth. They are gradually emerging in the field of tissue repair. However, at the present stage, the application of magnesium and its alloy implants is mainly for bone internal fixation, lacking the abili...

Claims

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Application Information

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IPC IPC(8): A61L27/20A61L27/02A61L27/18A61L27/54A61L27/56A61L27/58
CPCA61L27/025A61L27/18A61L27/20A61L27/54A61L27/56A61L27/58A61L2430/02A61L2300/604A61L2400/12C08L71/02C08L5/04
Inventor 许为康王丽艳郭瑞刘春燕
Owner INST OF MEDICINE & HEALTH GUANGDONG ACAD OF SCI