Surface hydrophilic layer modification method for implantable medical device and application

Abstract

The invention discloses a surface hydrophilic layer modification method for an implantable medical device and application, and belongs to the technical field of medical devices, and the surface hydrophilic layer modification method comprises plasma hydrophilic modification, hydrogel hydrophilic modification and biological extract modification. The surface of the medical device is modified through plasma hydrophilic modification or hydrogel prepared from biocompatible water-soluble polymers and viscous components, or a biological extract, so that a hydrophilic layer is formed, the surface lubricity of the biological medical device can be improved, resistance generated in the use process of the medical device is reduced, the damage to tissues caused by implantation of medical instruments is reduced, complications are reduced, and the biocompatibility is improved. The method has the advantages that the method is simple, the lubricating effect is good, the operation is convenient, and the method is safe, environmentally friendly and the like. The invention further discloses the surface hydrophilic layer of the implantable medical device and the implantable medical device modified by the hydrophilic layer.

Description

technical field [0001] The invention belongs to the technical field of medical devices, in particular to a method and application for modifying a surface hydrophilic layer of implantable medical devices. Background technique [0002] Implantable medical devices are in direct contact with tissues and organs in the human body, causing mutual friction, which may cause damage to tissues and organs, make patients feel uncomfortable, and even cause a series of complications in severe cases. Therefore, improve The surface lubricity of implantable medical devices is particularly important. Surface hydrophilic modification is an effective method to improve the lubrication effect of medical devices and reduce the friction between them and tissues and organs, and it is of great significance to promote the application of implantable medical devices. [0003] At present, the methods for hydrophilic treatment of the surface of medical devices mainly include: 1. By preparing a hydrogel la...

AI Technical Summary

Problems solved by technology

[0003] At present, the methods for hydrophilic treatment of the surface of medical devices mainly include: 1. By preparing a hydrogel layer on the surface of the medical device, the lubricity and hydrophilicity of the medical device are better improved. The instrument lacks a strong connection, and it is easy to fall off after multiple frictions, which affects the durable use of the hydrophilic layer (CN112574460A and CN107412883B); 2. By preparing t