Application of gypenoside B in antagonizing side effects of chemoradiotherapy and glucocorticoid hormone drugs, and preparation method of gypenoside B

Abstract

The invention belongs to the field of separation and extraction of traditional Chinese medicinal materials, and particularly relates to a novel medicine for antagonizing side effects of chemoradiotherapy and glucocorticoid hormone drugs, and application and a preparation method of gypenoside B. Existing drugs represented by glucocorticoid drugs show anti-inflammatory, anti-shock, anti-virus, immunosuppression and other treatment effects in numerous diseases, but simultaneously cause great side effects on patients, mainly being adrenal atrophy caused by long-term administration of glucocorticoid, metabolic disorder of sugar and salt and damage to the heart, the liver, the lung and the kidney. The preparation method comprises the following steps: S1, dissolving 20 kg of gynostemma pentaphyllum total saponins with methanol, mixing with 40 kg of silica gel, stirring, and volatilizing a solvent; and S2, loading on a 100 kg dry silica gel chromatographic column, and carrying out gradient elution with chloroform-methanol. The extracted gypenoside B drug is used for antagonizing side effects of glucocorticoid drugs and side effects generated by radiotherapy and chemotherapy, the curative effect is definite, and the gypenoside B is safe and free of toxic and side effects.

Description

technical field [0001] The invention relates to the technical field of separation and extraction of traditional Chinese medicinal materials, in particular to the application and preparation of gypenoside B in antagonizing side effects of radiotherapy, chemotherapy and glucocorticoids. Background technique [0002] Tumor is currently the most serious disease that endangers human health. Early tumors generally have no clinical symptoms. Once clinical manifestations appear, they are usually in the middle and late stages, and tumor metastasis has occurred. At present, the treatment of tumors is mainly through radiotherapy and chemotherapy. However, radiotherapy and chemotherapy have certain side effects on the body. They cannot kill all cancer cells, but can only kill cancer cells in proportion. The remaining cancer cells are weak and have low immunity. It develops rapidly and forms new lesions. The active ingredients extracted from Chinese herbal medicines are combined with t...

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Problems solved by technology

[0004] The purpose of the present invention is to solve the side effects caused by the drugs represented by glucocorticoid drugs in the prior art, which show anti-inflammatory, anti-shock, anti-viral and immunosuppressive effects in many diseases, but at the same time It is also very large, mainly the shortcoming of damage to the heart, liver, lung and kidney, and the application and preparation of a kind of gypenoside B proposed in antagonizing the side effects of radiotherapy and chemotherapy and glucocorticoid drugs

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