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Application of muscone in preparation of medicine for preventing and treating osteoarthritis

A technology of osteoarthritis and muscone, which is applied in the field of application of muscone in the preparation of drugs for preventing and treating osteoarthritis, and can solve problems such as unclear pathogenesis of KOA

Pending Publication Date: 2021-10-22
LONGHUA HOSPITAL SHANGHAI UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although biomechanical, metabolic, and genetic risk factors have been identified, the exact pathogenesis of KOA remains unclear, and finding targets for the prevention and treatment of KOA is a very active area of ​​research

Method used

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  • Application of muscone in preparation of medicine for preventing and treating osteoarthritis
  • Application of muscone in preparation of medicine for preventing and treating osteoarthritis
  • Application of muscone in preparation of medicine for preventing and treating osteoarthritis

Examples

Experimental program
Comparison scheme
Effect test

experiment example

[0022] 40 clean-grade 3-month-old C57BL male mice were randomly divided into Sham group, KOA group, positive control group and muscone group according to body weight. The rats in the control group were intragastrically administered with the same amount of normal saline every day, and the positive control group were intragastrically administered with Mobico every day. After continuous gavage treatment for 12 weeks, the swelling degree of the knee joint and the function of joint lymphatic reflux were detected, and then the knee joint was taken to make paraffin specimens, 4 μm serial sections, and stained with Alcian blue and orange red G (ABOG) to observe tissue damage, synovial hyperplasia and The destruction of articular cartilage was detected by ultrasound, the volume of synovial fluid in the knee joint cavity was detected by ultrasound, the cartilage COLX was observed by immunohistochemical staining, and the anti-inflammatory macrophage phenotype genes Arg1 and Fizz1 were det...

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Abstract

The invention relates to application of muscone in preparation of a medicine for preventing and treating osteoarthritis. As a medicine for treating osteoarthritis, the effective action concentration of the muscone (Muscone) is 6.25-25 [mu] M. The muscone is mixed with pharmaceutically acceptable pharmaceutical excipients to form powder, ointment, powder, injection, water aqua, enteric sustained release preparation or injection. Animal experiments prove that the muscone can reduce the OARSI score, synovial membrane area and cartilage defect of osteoarthritis mice and relieve knee joint tissue damage and swelling of the osteoarthritis mice.

Description

technical field [0001] The invention relates to the use of muscone in the preparation of medicines for preventing and treating osteoarthritis. Background technique [0002] Osteoarthritis (OA) is a common chronic degenerative disease of weight-bearing joints in clinical practice. , swelling, and joint deformity are the main clinical manifestations of total joint disease. The degeneration of articular cartilage in OA is irreversible, and there is still a lack of effective treatment drugs. High tibial osteotomy and joint replacement surgery are currently recognized as effective treatments for KOA. Although biomechanical, metabolic, and genetic risk factors have been discovered, the exact pathogenesis of KOA remains unclear, and finding targets for the prevention and treatment of KOA is a very active research area. [0003] In recent years, more and more studies have found that the immune system, especially synovial macrophages, play an important role in the degenerative proc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/122A61P19/02A23L33/00
CPCA61K31/122A61P19/02A23L33/00A23V2002/00A23V2200/30
Inventor 徐浩王拥军梁倩倩施杞王琼李强杨燕萍常君丽
Owner LONGHUA HOSPITAL SHANGHAI UNIV OF TRADITIONAL CHINESE MEDICINE