An Electrochemically Promoted Method for Meta-Nitration of Substituted Aromatic Hydrocarbons

Abstract

The invention discloses an electrochemically-promoted meta-nitrolation method for substituted aromatic hydrocarbons, which comprises dissolving compound I, nitrating reagents, ruthenium catalysts, phosphine ligands and electrolytes in a reaction solvent, and under the action of a constant current Perform an electrolysis reaction to generate compound II; wherein, DG is selected from substituted or unsubstituted 5-7 membered aromatic heterocyclic groups or 5-7 membered heterocyclic groups, and the substitution is substituted by C1-C5 alkyl or halogen. The present invention adopts the reaction system combining metal catalysis and electrochemistry, does not need to add additional chemical oxidation and reduction agents, has extremely high electron transfer efficiency, and has the advantages of mild reaction conditions, high product yield, good chemical selectivity, etc., and is more It is in line with the purpose of green and sustainable development in today's society.

Description

An electrochemically-promoted method for meta-nitration of substituted aromatic hydrocarbons technical field The invention belongs to substituted aromatic hydrocarbon meta-nitrogenation method technical field, be specifically related to a kind of electrochemically promoted substitution Aromatics meta-nitration method. Background technique [0002] Aromatic hydrocarbons are widely used in fields such as medicines, pesticides and materials as important intermediates in industrial production. in recent years The functionalization of aromatic compounds has gradually attracted extensive attention of researchers. Through the use of directing groups and metal catalysts The functionalization reaction of the ortho-position of substituted aromatic hydrocarbons has been successfully constructed with C-C bonds, C-O bonds, C-halogen bonds, C-N bonds, etc. With the construction of chemical bonds, the ortho-functionalized system of aromatic hydrocarbons has gradually matured. Howe...

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Problems solved by technology

[0004] Purpose of the invention: the technical problem to be solved by the present invention is to provide an electrochemically promoted meta-nitrolation method for substituted aromatic hydrocarbons, so as to solve the problems of environmental pollution and low product yield, poor reaction selectivity and large energy consumption in the prior art And other issues

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