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Intelligent bacterium collecting system

A tray and peristaltic pump technology, applied in the field of intelligent bacteria collection system, can solve the problems of low level of automation, integration and intelligence, difference between sterility inspection results and efficiency, and low efficiency of sterility inspection, so as to avoid indirect contamination , high degree of automation and high reliability

Pending Publication Date: 2021-10-26
HANGZHOU DIANZI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the bacteria collection operations involved in the sterility inspection all rely on manual operations, the level of automation, integration and intelligence is low, and the efficiency of the sterility inspection is low; There will be significant differences in sterility inspection results and efficiency due to different personnel operations
In the existing sterility testing process, faced with the problems of multi-sample types, multi-standard sample packaging, multi-process process analysis, discontinuous operation, and low efficiency of bacteria collection analysis, it is necessary to invent an intelligent bacteria collection operating system and way to solve

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] Embodiment 1: the aqueous solution test sample of 250ml and 100ml in multilayer large-capacity bottle.

[0056] Such as Figure 1~2 As shown, the intelligent bacteria collection system in this embodiment includes a guide rail (not shown in the figure), a first tray module 100 , a manipulator module 400 , a peristaltic pump module 500 , a turning mechanism module 600 and a control infusion module 700 . The tray module 100 is placed on the guide rail, a peristaltic pump module 500 is arranged on one side of the tray module 100, and a tray positioning device 333 is arranged on the other side of the first tray module 100; on platform 344. The control infusion module 700 is placed on the tray module 100 , can be moved to the infusion operation platform 344 by the manipulator module 400 , and fixed on the infusion operation platform 344 by the air cylinder and positioning pins.

[0057] A liquid outlet device is provided on the infusion operation platform 344 , and the liqu...

Embodiment 2

[0099] The ampoule bottled aqueous solution test sample of embodiment 2:10ml.

[0100] Such as Figure 15 and 16 As shown, the intelligent bacteria collection system in this embodiment includes a second tray module 130 , a bottle opening module 300 , a manipulator module 400 , a peristaltic pump module 500 , a turning mechanism module 600 and a control infusion module 700 .

[0101] The bottle opening module 300 and the peristaltic pump module 500 are arranged oppositely, and a guide rail is arranged in the middle of the bottle opening module 300 and the peristaltic pump module 500, and the second tray module 130 is placed on the guide rail; the bottle opening module 300 is fixed by the bottle opening module fixing plate; The module 400 and the peristaltic pump module 500 are fixed on the infusion operation platform 344 . The control infusion module 700 is placed on the tray module 100, and can be moved to the infusion operation platform 344 by the manipulator module 400, an...

Embodiment 3

[0130] Embodiment 3: 10ml of cillin bottled water-soluble solid test sample.

[0131] Such as Figure 27 and 28 As shown, this embodiment includes a bottle opening module 300 (only used for the pumping function, not related to bottle opening), a manipulator module 400, a peristaltic pump module 500, a turning module 600, a control infusion module 700, and a third tray module 160.

[0132] The difference between this embodiment and embodiment 2 lies in: the test product on the third tray module 160 is different, and the dissolving solution is housed in the transition bottle 119, which can play the role of dissolving the powder in the vial.

[0133] Such as Figure 29 As shown, the third tray module 160 includes a tray, a vial assembly 161 (vial, vial fixing plate), a blanking trough 310, a control infusion module 700, a moistening and cleaning solution bottle 111, a transition bottle 119, and a triple needle tooling 319 , the second needle 103 , the second hose installation ...

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Abstract

The invention relates to an intelligent bacterium collecting system. A bottle opening module and a peristaltic pump module are oppositely arranged, a guide rail is arranged between the bottle opening module and the peristaltic pump module, and a tray module is placed on the guide rail; and a manipulator module and the peristaltic pump module are fixed on an infusion operation platform. An infusion control module is placed on the tray module and can be moved to the infusion operation platform through the manipulator module and fixed. According to the invention, the traditional manual bacterium collection process is replaced, so that the bacterium collection process is quicker, meanwhile, secondary pollution possibly existing in the manual detection operation process is reduced, the accuracy of bacterium collection detection is improved, and the working efficiency is improved. The automation degree is high, manual operation is not needed in the bacterium collecting process, and the whole bacterium collecting process is completed. The adaptability degree is high, and bacterium collection detection of various test solution bottle samples can be realized.

Description

technical field [0001] The invention belongs to the technical field of intelligentization of sterility inspection systems, and relates to an intelligent bacteria collection system for different types of test products and test products with different packaging specifications. Background technique [0002] As the key to the quality control of food and drugs, sterility inspection is an important item for enterprises and regulatory agencies to inspect qualified products. The Pharmacopoeia of the People's Republic of China (abbreviated as "Chinese Pharmacopoeia") and the United States Pharmacopoeia USP31-NF26 Sterility Test Method "71" all put forward clear requirements. The sterility test of the test product can use membrane filtration method and direct inoculation method. Usually, the sterility test of the test product is tested by membrane filtration method, and if the membrane filtration technology is not suitable, the direct inoculation method of culture medium is used. Th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12M1/36C12M1/26
CPCC12M41/48C12M33/14C12M23/48C12M23/08C12M33/00C12M23/44C12M29/00C12M23/04C12M23/50
Inventor 黄雪峰李盛姬龚友平徐江荣
Owner HANGZHOU DIANZI UNIV
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