Preparation method of liposome with whitening and anti-aging effects

Abstract

The invention discloses a preparation method of a liposome with whitening and anti-aging effects. The preparation method comprises the following steps: mixing lecithin, cetyl phosphate, glabridin and dimethylmethoxy benzodihydropyranol, then, adding ascorbyl tetraisopalmitate, hexyldecanol and coconut oil alcohol-octoate / caprate, and carrying out heating, stirring and dissolving, so as to obtain an oil phase; adding the oil phase into water, carrying out stirring, and then, carrying out homogenizing and circulating, so as to obtain a liposome; adding hydroxypropyl trimethyl ammonium chloride hyaluronic acid into water, and carrying out uniform stirring, so as to obtain a hydroxypropyl trimethyl ammonium chloride hyaluronic acid solution; and dropwise adding the liposome into the hydroxypropyl trimethyl ammonium chloride hyaluronic acid solution in a stirring state, and carrying out uniform stirring, thereby obtaining the whitening and anti-aging liposome coated by the hydroxypropyl trimethyl ammonium chloride hyaluronic acid. The liposome has the characteristics that the stability can be effectively improved, the leakage of active substances is reduced, the retention level and retention time of the active substances in skin are increased, and a good whitening effect is achieved.

Description

technical field [0001] The invention relates to a method for preparing liposomes, in particular to a method for preparing liposomes with whitening and anti-aging effects. Background technique [0002] With the acceleration of the pace of society and the intensification of environmental pollution, modern women's demands for whitening and freckle removal have further increased. Compared with European and American women, Asian women have even more pursuit of whitening and brightening skin due to the inherent differences in skin color. The uneven distribution and accumulation of melanocytes on the surface of the skin can lead to dull skin and dark spots. The main pathway leading to the formation of melanin is that tyrosinase converts tyrosine into dopa, which is further oxidized into dopaquinone, and finally forms melanin. Over the years, the cosmetics industry has been constantly seeking technological breakthroughs and is committed to developing safe and efficient whitening in...

AI Technical Summary

Problems solved by technology

At present, most of the whitening products on the market add some traditional Chinese medicine extracts, vitamin C and its derivatives, glycolic acid, etc., because there are many reasons for the formation of melanin, if only a single ingredient of whitening ingredients is added, the whitening effect is not obvious, and some Whitening ingredients have poor stability, and will deteriorate under the influence of the external environment during storage and use, affecting their activity

[0003] Liposomes are spherical vesicles composed of lipid bilayers. They are often used for the delivery of active substances. They can not only protect the encapsulated substances from degradation, but also improve the physical and chemical properties of active substances and minimize their adverse reactions. At the same time, the bioavailability of the active substance at the target site is increased; therefore, researchers began to study how to encapsulate whitening ingredients in liposomes, but the whitening effect of the liposomes was not ideal

Moreover, existing liposomes still have certain limitations, such as poor stability, early drug leakage, and short and few residence times.