Preparation method of liposome with whitening and anti-aging effects

A liposome, anti-aging technology, applied in medical preparations containing active ingredients, preparations for skin care, pharmaceutical formulas, etc., can solve the problems of deterioration in storage and use, short residence time, affecting activity, etc., to increase retention amount and residence time, improving stability, increasing the effect of stability

Pending Publication Date: 2021-10-29
ZHEJIANG YIGE ENTERPRISE MANAGEMENT GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, most of the whitening products on the market add some traditional Chinese medicine extracts, vitamin C and its derivatives, glycolic acid, etc., because there are many reasons for the formation of melanin, if only a single ingredient of whitening ingredients is added, the whitening effect is not obvious, and some Whitening ingredients have poor stability, and will deteriorate under the influence of the external environment during storage and use, affecting their activity
[0003] Liposomes are spherical vesicles composed of lipid bilayers. They are often used for the delivery of active substances. They can not only protect the encapsulated substances from degradation, but also improve the physical and chemical properties of active substances and minimize their adverse reactions. At the same time, the bioavailability of the active substance at the target site is increased; therefore, researchers began to study how to encapsulate whitening ingredients in liposomes, but the whitening effect of the liposomes was not ideal
Moreover, existing liposomes still have certain limitations, such as poor stability, early drug leakage, and short and few residence times.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Example 1. A method for preparing liposomes with whitening and anti-aging effects, comprising the following steps:

[0028] Step 1. Mix lecithin, cetyl phosphate, glabridin and dimethylmethoxychromanol, then add ascorbyl tetraisopalmitate, hexyldecanol and cocoyl-octyl Ester / capric acid ester, heated to 50-80°C and stirred to dissolve to obtain an oil phase;

[0029] The second step is to add the oil phase to water at a temperature of 50-80°C, stir for 10-30 minutes, and then use a high-pressure homogenizer to homogenize and circulate 3-10 times under a pressure of 500-1500 bar to obtain liposomes;

[0030] Step 3, adding hydroxypropyltrimethylammonium chloride hyaluronic acid into water and stirring evenly to obtain a hydroxypropyltrimethylammonium chloride hyaluronic acid solution;

[0031] Step 4: Add liposomes dropwise to the hydroxypropyltrimethylammonium chloride hyaluronic acid solution under stirring, and then stir for 10-40 minutes to obtain the hyaluronic ac...

Embodiment 2

[0045] Example 2. A method for preparing liposomes with whitening and anti-aging effects, comprising the following specific steps:

[0046] The first step, take by weighing 10g lecithin, 1g cetyl phosphate, 0.4g glabridin, 0.04g dimethylmethoxychromanol and mix, then add 2g ascorbyl tetraisopalmitate, 4g of hexyldecyl alcohol, 20g of coconut oil-caprylate / caprate, heated to 60°C and stirred to dissolve to obtain an oil phase.

[0047] In the second step, the oil phase is added to 62.56 g of water (60° C.), stirred for 20 minutes, and then used a high-pressure homogenizer at 800 bar, homogenized and circulated 6 times to obtain liposomes.

[0048] Step 3: Weigh 1 g of hydroxypropyltrimethylammonium chloride hyaluronic acid and add 99 g of water to stir to obtain a hydroxypropyltrimethylammonium chloride hyaluronic acid solution.

[0049] Step 4: Weigh 50g of hydroxypropyltrimethylammonium chloride hyaluronic acid solution, add 50g of liposomes dropwise under stirring, and sti...

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Abstract

The invention discloses a preparation method of a liposome with whitening and anti-aging effects. The preparation method comprises the following steps: mixing lecithin, cetyl phosphate, glabridin and dimethylmethoxy benzodihydropyranol, then, adding ascorbyl tetraisopalmitate, hexyldecanol and coconut oil alcohol-octoate / caprate, and carrying out heating, stirring and dissolving, so as to obtain an oil phase; adding the oil phase into water, carrying out stirring, and then, carrying out homogenizing and circulating, so as to obtain a liposome; adding hydroxypropyl trimethyl ammonium chloride hyaluronic acid into water, and carrying out uniform stirring, so as to obtain a hydroxypropyl trimethyl ammonium chloride hyaluronic acid solution; and dropwise adding the liposome into the hydroxypropyl trimethyl ammonium chloride hyaluronic acid solution in a stirring state, and carrying out uniform stirring, thereby obtaining the whitening and anti-aging liposome coated by the hydroxypropyl trimethyl ammonium chloride hyaluronic acid. The liposome has the characteristics that the stability can be effectively improved, the leakage of active substances is reduced, the retention level and retention time of the active substances in skin are increased, and a good whitening effect is achieved.

Description

technical field [0001] The invention relates to a method for preparing liposomes, in particular to a method for preparing liposomes with whitening and anti-aging effects. Background technique [0002] With the acceleration of the pace of society and the intensification of environmental pollution, modern women's demands for whitening and freckle removal have further increased. Compared with European and American women, Asian women have even more pursuit of whitening and brightening skin due to the inherent differences in skin color. The uneven distribution and accumulation of melanocytes on the surface of the skin can lead to dull skin and dark spots. The main pathway leading to the formation of melanin is that tyrosinase converts tyrosine into dopa, which is further oxidized into dopaquinone, and finally forms melanin. Over the years, the cosmetics industry has been constantly seeking technological breakthroughs and is committed to developing safe and efficient whitening in...

Claims

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Application Information

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IPC IPC(8): A61K8/49A61K8/67A61K8/34A61K8/14A61K8/73A61Q19/02A61Q19/08
CPCA61K8/498A61K8/676A61K8/342A61K8/14A61K8/735A61Q19/02A61Q19/08A61K2800/592
Inventor 张大勇毕永贤杜雨涵周浩淼李昊刘金俊朱秀洁
Owner ZHEJIANG YIGE ENTERPRISE MANAGEMENT GRP CO LTD
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