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Application of inosine in preparation of antitumor drug or antitumor drug composition

A composition and anti-tumor technology, applied in the field of biomedicine, can solve the problems of poor curative effect, failure to prevent the rapid development of cancer, etc., and achieve the effects of convenient oral use, enhanced anti-tumor therapeutic efficacy, and reduced toxic and side effects

Pending Publication Date: 2021-10-29
BEIJING FRIENDSHIP HOSPITAL CAPITAL MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Clinically, comprehensive treatment is the main method. Surgery combined with radiotherapy and chemotherapy is effective for the treatment of early-stage tumors, but the curative effect is not good for advanced tumors.
Now for the treatment of advanced malignant solid tumors, various biological treatments provide more options, targeted drugs, antibodies, immunotherapy drugs (such as PD-1) and cell therapy (such as CAR-T, TIL cells), have made some progress, but The rapid development of cancer has not been stopped

Method used

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  • Application of inosine in preparation of antitumor drug or antitumor drug composition
  • Application of inosine in preparation of antitumor drug or antitumor drug composition
  • Application of inosine in preparation of antitumor drug or antitumor drug composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0066] Clinical research on inosine combined with PD-1 monoclonal antibody and chemotherapy / targeted therapy:

[0067] 1. Case selection

[0068] Patients with advanced malignant solid tumors who were treated in the Oncology Department of Beijing Friendship Hospital between October 2020 and July 2021, this study has been approved by the Ethics Committee of Beijing Friendship Hospital.

[0069] 2. Drug information

[0070] Inosine tablets are provided by Guangdong Hengjian Pharmaceutical Co., Ltd., the specification is 0.2g*100 tablets, the batch number is H44021166, and the experimental drugs meet the treatment standards for clinical research;

[0071] PD-1 monoclonal antibody (Erica) is provided by Suzhou Centia Biomedical Co., Ltd., the specification is 200mg / bottle, the batch number is s20190027, and the experimental drug meets the treatment standards for clinical research;

[0072] The chemotherapeutic drug is: Ayue (paclitaxel albumin-bound type for injection), provided...

Embodiment 2

[0089] Clinical research on inosine combined with PD-1 monoclonal antibody and chemotherapy:

[0090] 1. Case selection

[0091] Patients with advanced malignant solid tumors who were treated in the Oncology Department of Beijing Friendship Hospital between October 2020 and July 2021, this study has been approved by the Ethics Committee of Beijing Friendship Hospital.

[0092] 2. Drug information

[0093] Inosine tablets are provided by Guangdong Hengjian Pharmaceutical Co., Ltd., the specification is 0.2g*100 tablets, the batch number is H44021166, and the experimental drugs meet the treatment standards for clinical research;

[0094] PD-1 monoclonal antibody: Erica, provided by Suzhou Centia Biomedicine Co., Ltd., the specification is 200mg / bottle, the batch number is s20190027, and the experimental drug meets the treatment standards for clinical research;

[0095] The chemotherapeutic drug is: Ayue (paclitaxel albumin-bound type for injection), provided by Jiangsu Hengrui...

Embodiment 3

[0110] Clinical research on inosine combined with PD-1 monoclonal antibody and targeted therapy:

[0111] 1. Case selection

[0112] Patients with advanced malignant solid tumors who were treated in the Oncology Department of Beijing Friendship Hospital between October 2020 and July 2021, this study has been approved by the Ethics Committee of Beijing Friendship Hospital.

[0113] 2. Drug information

[0114] Inosine tablets are provided by Guangdong Hengjian Pharmaceutical Co., Ltd., the specification is 0.2g*100 tablets, the batch number is H44021166, and the experimental drugs meet the treatment standards for clinical research;

[0115] PD-1 monoclonal antibody (Erica) is provided by Suzhou Centia Biomedical Co., Ltd., the specification is 200mg / bottle, the batch number is s20190027, and the experimental drug meets the treatment standards for clinical research;

[0116] Anlotinib was provided by Chia Tai Tianqing Co., Ltd., with a specification of 8 mg, batch number 19092...

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Abstract

The invention relates to application of inosine in preparation of an antitumor drug or an antitumor drug composition. The invention creatively finds that when the inosine or a derivative thereof is combined with other tumor treatment modes for use, the antitumor treatment effect can be further enhanced or the tumor treatment drug resistance can be reversed, the toxic and side effects caused by other tumor treatment modes can be relieved, and a brand-new treatment strategy and a brand-new sensitizing factor are provided for an existing tumor treatment method. Moreover, the inosine serving as a non-prescription drug has the advantages of economy and practicability, so that the economic burden of a patient is greatly relieved; the inosine has the advantages of safety and low toxicity, thereby significantly improving the living quality of the patient; and the oral administration is convenient, so that the complex process of intestinal microorganism transplantation is avoided. The inosine, as a highest-potency-ratio partner of the antitumor drug, can bring great social benefits and economic benefits.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and relates to the application of inosine in the preparation of antitumor drugs or antitumor drug compositions. Background technique [0002] There are three traditional modes of tumor treatment: surgery, radiation, and chemotherapy (including targeted therapy), as well as new types of biological therapy (including immunotherapy). Clinically, comprehensive treatment is the main method. Surgery combined with radiotherapy and chemotherapy is effective for early-discovered tumors, but the curative effect is not good for advanced tumors. Now for the treatment of advanced malignant solid tumors, various biological treatments provide more options, targeted drugs, antibodies, immunotherapy drugs (such as PD-1) and cell therapy (such as CAR-T, TIL cells), have made some progress, but It has not been able to prevent the rapid development of cancer. [0003] The gut microbiota not only plays an impor...

Claims

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Application Information

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IPC IPC(8): A61K45/06A61K31/708A61K39/395A61K31/337A61K33/243A61K31/4709A61P35/00A61P35/02
CPCA61K45/06A61K31/708A61K39/395A61K31/337A61K33/243A61K31/4709A61P35/00A61P35/02A61K2300/00
Inventor 李琴袁向亮何宝坤卢雨亭
Owner BEIJING FRIENDSHIP HOSPITAL CAPITAL MEDICAL UNIV
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