Kit for predicting occurrence risk of acute respiratory distress syndrome and use method of kit

A technology for acute respiratory distress and risk prediction, applied in the medical field, can solve problems such as being in the blank stage, and achieve the effects of simple and easy detection methods, objective and reliable detection results, high sensitivity and specificity

Inactive Publication Date: 2021-10-29
NANJING MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the predictive value of mannose for the risk of ARDS is still in the blank stage

Method used

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  • Kit for predicting occurrence risk of acute respiratory distress syndrome and use method of kit

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] Embodiment 1 The first aspect provides a risk prediction kit for acute respiratory distress syndrome, including EDTA disodium, isotope internal standard agent, internal standard diluent, ammonium acetate aqueous solution, formic acid acetonitrile aqueous solution, acetonitrile, solid phase extraction plate , Aqueous acetic acid solution.

[0050] In this embodiment, the internal standard diluent is a methanol solution containing ascorbic acid at a mass concentration of 0.5% and an aqueous solution containing ascorbic acid at a mass concentration of 0.5%.

[0051] In this embodiment, the mass concentration of the formic acid acetonitrile aqueous solution is 3%.

[0052] In this embodiment, the mass concentration of the aqueous acetic acid solution is 0.4%.

[0053] In this example, the detection and prediction target population of the kit is the acute and severe patients in the intensive care unit; the demographic characteristics and pathophysiological indicators of the...

Embodiment 2

[0059] The specific implementation of this example is the same as that of Example 1, except that: the internal standard diluent only adopts a methanol solution containing ascorbic acid at a mass concentration of 0.5%.

Embodiment 3

[0061] The specific implementation of this example is the same as that of Example 1, except that: the mass concentration of the formic acid acetonitrile aqueous solution is 4%; the mass concentration of the acetic acid aqueous solution is 0.2%.

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Abstract

The invention provides a kit for predicting the risk of acute respiratory distress syndrome and a use method of the kit. The kit at least comprises an anticoagulant, an internal standard agent, an internal standard diluent, an ammonium acetate aqueous solution, an eluent, an auxiliary solution, a solid-phase extraction plate and a resolvent. According to the invention, the risk of the acute respiratory distress syndrome of ICU patients is predicted on the basis of the level of serum mannose, high sensitivity and specificity are achieved, a new method and a marker for recognizing high-risk patients are provided for predicting the acute respiratory distress syndrome, and excellent clinical value is achieved.

Description

technical field [0001] The invention relates to an acute respiratory distress syndrome occurrence risk prediction kit and a use method thereof in the medical field. Background technique [0002] Acute respiratory distress syndrome (ARDS) is a common type of comprehensive critical illness in the intensive care unit (ICU). The mortality rate of patients with ARDS is still about 40%. Currently, effective treatment measures for ARDS are very limited. Therefore, early prediction of the risk of ARDS in acute and severe patients is the key to reducing their mortality. [0003] With the development of glycobiology, the anti-inflammatory biological functions of some sugars are gradually recognized. Mannose is a simple hexose sugar that has been found to have anti-inflammatory properties. Mannose can inhibit the inflammatory response during wound healing, inhibit the oxidative burst of neutrophils, and has various effects such as anti-inflammation, anti-oxidation, and reduction of ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02G01N30/06G01N30/72G01N30/86G06F30/20
CPCG01N30/02G01N30/06G01N30/72G01N30/8696G06F30/20G01N2030/062
Inventor 魏永越黄慧张汝阳沈思鹏陈峰
Owner NANJING MEDICAL UNIV
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