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A kind of pharmaceutical composition for preventing and treating spirulina vibriosis and its preparation method and application

The technology of a square snail and its composition is applied in the field of aquaculture, which can solve the problems of high mortality, rapid outbreak, and drug resistance of pathogenic bacteria, and achieve the effects of improving drug efficacy, reducing mortality, and improving drug efficacy

Active Publication Date: 2022-05-27
GUANGDONG OCEAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Vibrio harveii is the main pathogenic bacterium of snail snail edema disease. The disease outbreak speed is fast, the disease period is short, and the mortality rate is high. If it is not controlled in time, the mortality rate can be as high as 100%. The aquaculture industry has caused serious economic losses, and no effective prevention method has been found so far. Usually, on the basis of ensuring clean water quality, the diseased snails are soaked in antibiotics and antibacterial drugs. The abuse of antibiotics leads to ecological problems such as pathogenic bacteria resistance and drug residues. , affecting the food safety of Fangban Dongfeng snails, and the pathogenic bacteria have developed drug resistance, and the treatment effect is not good

Method used

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  • A kind of pharmaceutical composition for preventing and treating spirulina vibriosis and its preparation method and application
  • A kind of pharmaceutical composition for preventing and treating spirulina vibriosis and its preparation method and application
  • A kind of pharmaceutical composition for preventing and treating spirulina vibriosis and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043]Weigh 30 g of gall, 20 g of green fruit, 10 g of skullcap, 5 g of hawthorn, 5 g of honeysuckle, 6 g of myrobalan and 5 g of black plum, crush gall, green fruit, skullcap, hawthorn, honeysuckle, myrobalan and black plum respectively, sieve, mix well and add 162 mL Soak in distilled water for 30 minutes, heat to boiling, simmer for 30 minutes, filter, add 162 mL of distilled water to the filter residue and soak for 30 minutes, heat to boiling, simmer for 30 minutes, filter, combine two filtrates, then evaporate, concentrate, and sterilize to obtain the content of each original drug It is a compound Chinese herbal medicine preparation of 1.0g / mL. 8 parts of compound Chinese herbal medicine preparations and 2 parts of doxycycline hydrochloride with a concentration of 1 mg / mL were weighed and mixed according to parts by weight to obtain a pharmaceutical composition for preventing and treating Helicobacter spirovibrosis.

Embodiment 2

[0045] Weigh 10 g of gall, 15 g of green fruit, 20 g of skullcap, 1 g of hawthorn, 1 g of honeysuckle, 10 g of myrobalan, and 1 g of black plum, crush gall, green fruit, skullcap, hawthorn, honeysuckle, myrobalan, and black plum respectively, sieve, and add 58 mL after mixing evenly. Soak in distilled water for 40min, heat to boiling, simmer for 32min, filter, add 58mL of distilled water to filter residue and soak for 28min, heat to boiling, simmer for 20min, filter, combine two filtrates, then evaporate, concentrate, and sterilize to obtain the content of each original drug It is a compound Chinese herbal medicine preparation of 1.0g / mL. 10 parts of compound Chinese herbal medicine preparations and 3 parts of doxycycline hydrochloride with a concentration of 1 mg / mL were weighed and mixed according to parts by weight to obtain a pharmaceutical composition for preventing and treating spirovibrosis.

Embodiment 3

[0047] Weigh 25 g of gall, 30 g of green fruit, 18 g of skullcap, 4 g of hawthorn, 2 g of honeysuckle, 1 g of myrobalan, and 2 g of black plum, crush gall, green fruit, skullcap, hawthorn, honeysuckle, myrobalan and black plum respectively, sieve, mix well and add 246 mL Soak in distilled water for 35 minutes, heat to boiling, simmer for 30 minutes, filter, add 82 mL of distilled water to filter residue and soak for 20 minutes, heat to boiling, simmer for 30 minutes, filter, combine two filtrates, then evaporate, concentrate, and sterilize to obtain the content of each original drug It is a compound Chinese herbal medicine preparation of 1.0g / mL. Weigh 1 part of compound Chinese herbal medicine preparation and 5 parts of doxycycline hydrochloride with a concentration of 1 mg / mL and mix them according to parts by weight to obtain a pharmaceutical composition for preventing and treating Helicobacter spirovibrosis.

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Abstract

The invention discloses a pharmaceutical composition for preventing and treating spirulina spirulina and its preparation method and application, belonging to the technical field of aquaculture. The pharmaceutical composition comprises the following components by weight: 1-10 parts of compound Chinese herbal medicine preparation (1g / mL) and 1-5 parts of doxycycline hydrochloride (1mg / mL) (wherein the compound Chinese herbal medicine preparation includes the raw materials of the following weight parts : 10-30 parts of Galla chinensis, 15-30 parts of green fruit, 10-20 parts of Scutellaria baicalensis, 1-5 parts of Hawthorn, 1-5 parts of honeysuckle, 1-10 parts of myrobalan and 1-5 parts of black plum. Pharmaceutical composition of the present invention The combination of Chinese and Western medicines has a synergistic effect, can greatly improve the efficacy of treating Fangbandongfeng spirulina vibriosis, and can effectively reduce the mortality rate of the diseased Fangbandongfeng snails. The preparation steps are simple and can be mass-produced .

Description

technical field [0001] The present invention relates to a medicinal composition for preventing and treating spirovibrosis orientalis, a preparation method and application thereof, and belongs to the technical field of aquaculture. Background technique [0002] Fangban Dongfeng snails belong to the phylum Molluscs, Gastropoda, Neogastropoda, Moth snails, and inhabit the sandy bottom of tropical and subtropical waters at a depth of 5-20m. Mainly distributed in Fujian, Guangdong, Hainan and other places, it has large individuals, strong disease resistance, fast growth, tender and delicious meat, and has high economic and nutritional value. [0003] In recent years, with the rapid expansion of the Fangban Dongfeng snail breeding industry, the farmers' one-sided pursuit of economic interests has led to an increasing breeding density, and the sewage generated during the breeding process is also discharged at will, resulting in the continuous deterioration of the breeding environme...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/736A61K31/65A61P31/04A61K35/64
CPCA61K35/64A61K36/32A61K36/539A61K36/734A61K36/355A61K36/185A61K36/736A61K31/65A61P31/04A61K2236/331A61K2236/39A61K2300/00
Inventor 汤菊芬简纪常黄瑜蔡佳王蓓蔡双虎黄郁葱鲁义善
Owner GUANGDONG OCEAN UNIVERSITY