Mechanical ball milling assisted synthesis method of 2-amino-3-cyano-4H-pyran compound

Abstract

The invention relates to the technical field of chemical synthesis, and discloses a mechanical ball milling assisted synthesis method of a 2-amino-3-cyano-4H-pyran compound in order to solve the problems that in the prior art, a chemical method for synthesizing a 2-amino-3-cyano-4H-pyran compound cause large pollution and uses a catalyst which is tedious in preparation. The method comprises the following steps: (a) by taking a substrate 1, a substrate 2 and malononitrile as raw materials, adding a protein catalyst and a grinding aid, and then carrying out mechanical ball milling; and (b) after the ball milling is finished, scraping out a reactant, adding a solvent, filtering, concentrating, and carrying out column chromatography to obtain the 2-amino-3-cyano-4H-pyran compound. The mechanical ball milling technology is beneficial to mutual contact of reactant molecules, solvent-free reaction is achieved, and the protein catalyst is easy to obtain and environmentally friendly. Green synthesis of the 2-amino-3-cyano-4H-pyran compound is effectively realized, the preparation condition is mild, the operation is simple and convenient, and the reaction rate is high.

Description

technical field [0001] The invention relates to the technical field of chemical synthesis, in particular to a mechanical ball milling-assisted synthesis method of 2-amino-3-cyano-4H-pyran compounds. Background technique [0002] 2-Amino-3-cyano-4H-pyran compounds have a variety of important biological and pharmacological activities, such as anti-tumor, anti-bacterial, anti-allergic and anti-aging functions. Such compounds are generally prepared by chemical methods, but chemical methods have disadvantages such as complex catalyst preparation and difficult product separation, which restrict the practical application of chemical synthesis of 2-amino-3-cyano-4H-pyran compounds, and Commonly used chemical synthesis requires the use of organic reagents as solvents, which will cause greater pressure on the environment. [0003] For example, a "supported imidazole ionic liquid catalyst and method for synthesizing 2-amino-3-cyano-4H-pyran compounds" disclosed in Chinese patent liter...

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Problems solved by technology

[0004] The present invention provides a kind of 2-amino-3-cyano-4H-pyran compounds in the prior art in order to overcome the problems of cumbersome catalyst preparation, heating and long synthesis time in the synthesis process, in order to overcome the chemical synthesis of 2-amino-3-cyano-4H-pyran compounds in the prior art. -A mechanical milling-assisted synthesis method of amino-3-cyano-4H-pyran compounds, the synthesis reaction of this method is a solvent-free reaction, the reaction conditions are mild, the synthesis efficiency and yield are high, and the reaction uses protein as a catalyst, which has the advantages of Less pollution, friendly to the environment, etc.

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