Method for identifying effective components in four-ministerial cough granules

Abstract

The invention relates to a method for identifying effective components in four-ministerial cough granules. The method comprises the following steps: obtaining a four-ministerial cough relieving particle sample solution; and analyzing the sample solution of the four-ministerial antitussive granules by adopting a liquid chromatography-mass spectrometry method, and determining the effective components in the four-ministerial antitussive granules based on an obtained liquid chromatography result, wherein a mobile phase adopted in chromatographic conditions of the liquid chromatography comprises a mobile phase A and a mobile phase B, wherein the mobile phase A is selected from a formic acid aqueous solution, and the mobile phase B is selected from acetonitrile. According to the method, the effective components of the four-ministerial antitussive granules can be efficiently and rapidly represented, the detection time is shortened, meanwhile, the accuracy is improved, and more bases are provided for subsequent quality analysis and quality control of the four-ministerial antitussive granules.

Description

technical field [0001] The invention belongs to the technical field of detection, and in particular relates to a method for identifying active ingredients in Sichen Zhike Granules. Background technique [0002] Sichen Zhike Granules is from the "New Tibetan Medicine Formula", which is composed of rock cabbage, crab nails, licorice, and Artemisia scoparia. It is a classic ancient prescription in Tibetan medicine theory. It has the effects of clearing away heat and detoxification, relieving cough and asthma, moisturizing the throat and eliminating phlegm . [0003] At present, the research on Sichen Zhike Granules mainly focuses on the extraction process and pharmacodynamics, such as the acute attack of chronic bronchitis, etc. There are few studies on its active ingredients, which are usually limited to the content determination of individual medicinal flavor index components. Detection components are limited. The Tibetan medicine compound is consistent with the traditional...

AI Technical Summary

Problems solved by technology

[0003] At present, the research on Sichen Zhike Granules mainly focuses on the extraction process and pharmacodynamics, such as the acute attack of chronic bronchitis, etc. There are few studies on its active ingredients, which are usually limited to the content determination of individual medicinal flavor index components. Detected components are limited

The Tibetan medicine compound is the same as the traditional Chinese medicine compound, containing a variety of chemical active ingredients, and only controlling the content of a few chemical ingredients cannot control its overall quality and clinical efficacy.

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