Near-infrared fluorescent probe for detecting chromium ions and aluminum ions and preparation method and application thereof
A fluorescent probe, aluminum ion technology, used in chemical instruments and methods, fluorescence/phosphorescence, luminescent materials, etc., can solve the problems of few fluorescent sensors, limit the development of probes, interfere with fluorescence imaging of cells, etc., and achieve enhanced fluorescence intensity. Effect
Active Publication Date: 2021-11-16
XUCHANG UNIV
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Problems solved by technology
Cr 3+ The increase or decrease of the content will affect the normal physiological activities and increase the risk of disease
Due to Cr 3+ Due to its own paramagnetic properties, it is easy to quench the fluorescence, because the fluorescence quenching is not easy to identify the output of the fluorescent signal, which interferes with the fluorescence imaging of the cells, thus limiting the detection of Cr 3+ The development of the probe
In particular, the development of Cr that can be used in organisms at the cellular level 3+ The near-infrared fluorescence sensor is a fluorescence-enhanced type, which is very difficult and challenging
[0005] Currently targeting Al 3+ or Cr 3+ Fluorescence sensors that excite and emit in the near-infrared region rarely
Method used
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Embodiment 1
[0037] The preparation method of the fluorescent probe of the present embodiment comprises the following steps:
[0038]
[0039] (1) Preparation of Compound LF-2
[0040] Take 8 mL of concentrated sulfuric acid (commercially available 98% concentrated sulfuric acid) in a 50 mL pear-shaped bottle, and stir at 0 °C for 20 min. Cyclohexanone (0.2941 g, 3.0 mmol) was slowly injected into the bottle, stirred for 15-20 min, and then LF-1 (0.4691 g, 1.5 mmol) was added to the reaction solution in small amounts and controlled within 30 min After the addition, the solution gradually changed from colorless to red. After the solid was completely dissolved, it was heated at 92 °C for 4 h. After the reaction was complete, stop heating, cool to room temperature, and then slowly pour the reaction solution into 480 mL of ice water. beaker, and stirred, then added dropwise 1.5 mL HClO 4 , accompanied by the precipitation of a red solid, which was filtered with suction, washed with cold w...
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The invention belongs to the technical field of organic synthesis, and particularly relates to a near-infrared fluorescent probe for detecting chromium ions and aluminum ions and a preparation method and application of the near-infrared fluorescent probe. Rhodamine hemicyanine serves as a fluorophore, 8-hydroxyquinoline-2-formaldehyde serves as a recognition group, and the probe realizes specific recognition response to chromium ions and aluminum ions, and has a structure shown in the specification; the fluorescence of the probe is extremely weak, and the fluorescence is enhanced after the probe reacts with the chromium ions and the aluminum ions, and the solution becomes green from colorless, and can be identified by naked eyes without being influenced by interference ions, and the probe can be used for detecting the chromium ions and the aluminum ions. The probe has a wide application scene in the biological field.
Description
technical field [0001] The invention belongs to the technical field of organic synthesis, and specifically relates to a near-infrared fluorescent probe for detecting chromium ions and aluminum ions, a preparation method and application thereof. Background technique [0002] Metal ions are widely used in our daily life, such as in our heavy industry, light industry, textile industry, food processing, and pharmaceutical production process, which brings great convenience to our life and production. We live in an environment accompanied by metal ions for a long time. Different metal ions through the food chain accumulate in the human body, and enrichment may cause a series of diseases caused by metal ions, such as slow growth, memory impairment, cancer and other diseases. Therefore, health problems caused by metal ions are also attracting more and more attention. [0003] Al 3+ It is especially common in our living environment, such as our kitchen utensils, food additives, fo...
Claims
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Patent Timeline
Login to View More IPC IPC(8): C07D491/107C09K11/06G01N21/64
CPCC07D491/107C09K11/06G01N21/6428G01N21/643C09K2211/1033C09K2211/1029
Inventor 许志红周起航杨莉刘高兵杨涵熙许泗林许锐杰高志颖段颖颖潘明霞
Owner XUCHANG UNIV