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Platelet function testing device, kit and application thereof

A function test, platelet technology, applied in the direction of analysis materials, instruments, etc., can solve the problems of consistency of results, long test time, cumbersome operation, etc., to eliminate the risk of cross-contamination and test uncertainty, reduce purchase and maintenance Cost, effect of improving accuracy

Pending Publication Date: 2021-11-26
美高怡生生物电子科技(北京)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The design of the system is very complicated, and the maintenance and debugging are cumbersome
[0005] Although the existing fully automatic blood coagulation testing technology and reagents have been widely used, its most notable disadvantages are the complex equipment system, cumbersome operation, high cost, and the testing process cannot completely simulate the vascular environment.
There is coagulation time in coagulation method or optical turbidimetry test, the test time is long, it is easy to cause cross-contamination, and the consistency of test results needs to be improved

Method used

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  • Platelet function testing device, kit and application thereof
  • Platelet function testing device, kit and application thereof
  • Platelet function testing device, kit and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0071] see figure 2 with image 3 As shown, the present embodiment provides a platelet function testing device, which includes a bottom plate (base plate with reference to image 3 As shown), a sample chamber, a sample passage, a stirring chamber and a blood flow passage are prefabricated on the bottom plate, the sample chamber communicates with the stirring chamber through the sample passage, and the stirring chamber communicates with the blood flow passage.

[0072] The sample to be tested is loaded from the sample chamber, and under the thrust of the stirring chamber, the sample to be tested flows into the stirring chamber along the sample path, and finally flows into the blood flow path. In this embodiment, a magnetic stirring bar is arranged in the stirring chamber, and the motor arranged under the stirring bar drives the impeller with opposite magnetic poles to rotate, so as to realize stirring and provide power for blood flow.

[0073] There is a platelet inducer coa...

Embodiment 2

[0079] see Figure 4 As shown, this embodiment provides a test kit for AA and ADP platelet function.

[0080] The kit also includes a matching instruction manual, a bottom plate, and a packing box. There are three grooves on the bottom plate, which are respectively used as a sample chamber and two mixing chambers. The sample passage is drawn from the sample chamber, which is divided into two branches. One arm was used to assess response to aspirin therapy and the other arm was used to assess response to P2Y12 inhibitors.

[0081] The inner wall of the stirred chamber of the branch used for aspirin treatment response evaluation was coated with arachidonic acid (AA), and the inner wall of the stirred chamber of the other branch was coated with ADP coating and alprostadil (PGE1) coating. A fibrinogen (Fibrinogen) coating is provided on the inner wall of the blood flow channel.

[0082] Studies have shown that most patients who take aspirin have prolonged migration distance. P...

Embodiment 3

[0084] see Figure 5 as shown, Figure 5 The structure is modeled after atherosclerotic stenosis of blood vessel thrombus formation. This embodiment provides a platelet function test kit. Compared with Example 1, the only difference is that there are microspheres with a thickness of about 45 microns in the blood flow channel, the average particle diameter of the microspheres is 5 μm, and the microspheres have hollow micropores. The hollow microspheres are used to form a diameter of The narrow channel of about 0.5 mm, the blood flows through the microsphere micropore in the middle. The process of thrombus formation in atherosclerotic stenosis can thus be simulated. The kit can be used to prevent accidents and patient reactions to medications.

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Abstract

The invention provides a platelet function testing device, a kit and application thereof, and relates to the technical field of blood function testing. The device comprises a bottom plate, and a sample chamber, a sample passage, a stirring chamber and a blood flow passage are prefabricated on the bottom plate. A platelet inducer coating is arranged on the inner wall of the stirring chamber, and an extracellular matrix protein coating is arranged on the inner wall of the blood flow passage. The platelet function testing device has no complex sampling system or motion control system so that the potential cross contamination risk of sampling and the testing uncertainty are eliminated. Besides, the testing device can completely simulate the internal environment of the blood vessel, so that the accuracy, the consistency and the reliability of the test are improved. In addition, the platelet function testing device is simple in design, purchase and maintenance cost of a testing system is greatly reduced, and the platelet function testing device has good maintainability.

Description

technical field [0001] The invention relates to the technical field of blood function testing, in particular to a platelet function testing device, a kit and applications thereof. Background technique [0002] Current biochemical tests, blood coagulation testing and platelet function testing equipment generally use separate sample cups, reagent cups and reaction cups. Samples and reagents are stored in sample cups and reagent cups respectively. When biochemical tests are performed, the samples and reagents are sucked by the sampling device, and they are moved to the reaction cups for reaction in the reaction cups. [0003] In coagulation and platelet testing, coagulation and optical turbidimetry (LTA) are commonly used. Its core is to use optical methods to detect the products in the reaction process of blood samples and reagents, and to record the blood coagulation process by detecting the change of scattered light signal, and obtain the coagulation curve. Among them, the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N35/00
CPCG01N35/00G01N2035/00534G01N2035/00178
Inventor 任宏超陈堃
Owner 美高怡生生物电子科技(北京)有限公司
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