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Naphthalene phthalocyanine copper self-assembly material, naphthalene phthalocyanine copper and Au composite material and preparation method and application of Naphthalene phthalocyanine copperself-assembly material and naphthalene phthalocyanine copper and Au composite material

A technology of copper naphthalocyanine and composite materials, which is applied in the direction of nanotechnology, splitting materials, and drug combination for materials and surface science. It can solve the problems of low ground state energy and limited applications, so as to increase the effective concentration and improve phagocytosis. Quantify and enhance the effect of sonodynamic therapy

Active Publication Date: 2021-11-30
HENAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The unique macrocyclic planar conjugated system of naphthalocyanine makes the ground state energy of the molecule very low, so naphthalocyanine has good physical and chemical stability, light resistance, heat resistance, acid and alkali resistance, water immersion resistance and other advantages, but no substitution Naphthalocyanine is almost insoluble in organic solvents, which greatly limits its application

Method used

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  • Naphthalene phthalocyanine copper self-assembly material, naphthalene phthalocyanine copper and Au composite material and preparation method and application of Naphthalene phthalocyanine copperself-assembly material and naphthalene phthalocyanine copper and Au composite material
  • Naphthalene phthalocyanine copper self-assembly material, naphthalene phthalocyanine copper and Au composite material and preparation method and application of Naphthalene phthalocyanine copperself-assembly material and naphthalene phthalocyanine copper and Au composite material
  • Naphthalene phthalocyanine copper self-assembly material, naphthalene phthalocyanine copper and Au composite material and preparation method and application of Naphthalene phthalocyanine copperself-assembly material and naphthalene phthalocyanine copper and Au composite material

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Experimental program
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Effect test

Embodiment 1

[0032] A preparation method of copper naphthalocyanine self-assembled nanomaterials, comprising the following steps:

[0033] 1) Weigh 10 mg of copper naphthalocyanine and dissolve it in 1 mL of chloroform to prepare a 10 mg / mL solution;

[0034]2) Prepare 10 mL of SDS aqueous solution with a concentration of 0.0025 mol / L;

[0035] 3) Under stirring, quickly inject 1 mL of the solution in step 1) into the solution in step 2), sonicate the probe for 2 minutes (power is 80 W), then transfer to a 65°C water bath, and quickly volatilize under stirring for 10 minutes , volatilize all the chloroform solution, then quickly cool to room temperature in an ice-water bath, and centrifuge at 13000r / min, the resulting precipitate is copper naphthalocyanine self-assembled nanomaterials, see SEM pictures figure 1 a.

[0036] The difference from the above scheme is that the concentration of SDS in the replacement step 2) is 0.01 mol / L ( figure 1 B), 0.0125 mol / L ( figure 1 C), 0.015 mol / L...

Embodiment 2

[0039] A preparation method of copper naphthalocyanine and Au composite material, comprising the following steps:

[0040] 1) Dissolve 10 mg copper naphthalocyanine in 0.5 mL chloroform to prepare a 20 mg / mL copper naphthalocyanine / chloroform solution;

[0041] 2) Disperse the synthesized gold nanoparticles in chloroform to prepare a 40 mg / mL Au / chloroform solution;

[0042] 3) At room temperature, add 0.5 mL of the solution obtained in step 1) to 0.5 mL of the solution in step 2), and mix ultrasonically for 3-6 minutes to prepare a mixed solution of copper naphthalocyanine / gold nanoparticles / chloroform;

[0043] 4) Prepare 10 mL of SDS aqueous solution with a concentration of 0.015 M;

[0044] 5) Add the solution of step 3) to the solution of step 4), sonicate the probe for 2 minutes (power is 80 W), volatilize in a water bath at 65°C for 10 minutes, evaporate all the chloroform solution, and then quickly cool it in an ice-water bath to Centrifuge at room temperature at 130...

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Abstract

The invention discloses a naphthalene phthalocyanine copper self-assembly material, a naphthalene phthalocyanine copper and Au composite material and a preparation method and application of the naphthalene phthalocyanine copper self-assembly material and the naphthalene phthalocyanine copper and Au composite material. The preparation method comprises the following steps of (1) preparing a chloroform solution of naphthalene phthalocyanine copper; (2) preparing chloroform of Au; (3) preparing SDS aqueous solutions with different concentrations; and (4) adding the solution obtained in the step (1) into the step (3) or mixing the solutions obtained in the step (1) and the step (2), then adding the mixed solution into the step (3), carrying out ultrasonic treatment on a probe, then volatilizing in a water bath, and carrying out centrifugal separation to obtain precipitates, namely the naphthalene phthalocyanine copper self-assembly material and the composite material of the naphthalene phthalocyanine copper self-assembly material and the gold nanoparticles. According to the method, overexpressed H2O2 in a tumor microenvironment is effectively responded due to the introduction of gold particles, so that on one hand, the problem of tumor hypoxia is solved, meanwhile, the sonodynamic therapy performance of naphthalene phthalocyanine copper is effectively enhanced. The method is simple and efficient, can be used for large-scale preparation, is finally applied to photothermal therapy and sonodynamic therapy reagents, has the advantages of good photothermal performance, small dosage, obvious sound sensitivity enhancement and the like.

Description

technical field [0001] The invention belongs to the fields of material chemistry, organic supramolecular chemistry and bionano medicine, and specifically relates to a copper naphthalocyanine self-assembly material, a copper naphthalocyanine and Au composite material, and a preparation method and application thereof. Background technique [0002] With the development of society, the continuous deterioration of the environment, and the aggravation of problems such as population aging, the incidence and mortality of cancer are increasing rapidly. It is urgent to find appropriate and efficient cancer treatment methods to prolong patients' lives. The current clinical treatment methods for cancer mainly include surgery, chemotherapy and radiotherapy. However, these treatment techniques have certain limitations. How to achieve more efficient and precise treatment has become an urgent problem to be solved in the process of cancer treatment. Photothermal therapy produces a better ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K49/22A61P15/00A61P35/00B82Y5/00B82Y30/00B82Y40/00
CPCA61K49/22A61K41/0052A61K41/0033A61P35/00A61P15/00B82Y5/00B82Y30/00B82Y40/00A61K2300/00
Inventor 钟永葛炎白锋鲍建帅李增银
Owner HENAN UNIVERSITY
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