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High-density polyethylene surface-modified composite scaffold as well as preparation method and application thereof

A technology of high-density polyethylene and composite scaffolds, which is applied in coatings, medical science, prostheses, etc., can solve the problems that the molding methods cannot be personalized to meet the needs, poor bone tissue integration ability, and low biological activity, etc., and achieve biological Active and well integrated with the body's bone tissue, promote the formation of body blood vessels, simple and effective process

Active Publication Date: 2021-11-30
CHANGZHOU HUALIAN HEALTH DRESSING LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The purpose of the present invention is to overcome the existing high-density polyethylene (HDPE) repair materials with low bioactivity, poor integration with body bone tissue, and inability to personalize molding methods to meet the needs; for this reason, the present invention provides a biological Preparation method of personalized high-density polyethylene surface-modified composite scaffold with activity and good integration with body bone tissue

Method used

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  • High-density polyethylene surface-modified composite scaffold as well as preparation method and application thereof
  • High-density polyethylene surface-modified composite scaffold as well as preparation method and application thereof
  • High-density polyethylene surface-modified composite scaffold as well as preparation method and application thereof

Examples

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Embodiment 1

[0048] A method for preparing high density polyethylene surface modified composite brackets, including the following steps:

[0049] S1, using the SOL IDWORKS software to draw a cylinder with a diameter of 10mm, saved in STL format; open nitrogen, 3D printer, Perfactory RP slice software, after sesame model Import 3D printer control software VisulMachines, operation 3D control software gives print nozzle 200 The high temperature of ° C is placed in the spray head, and a high density polyethylene (HDPE) powder is added, and after the matrix material is melted into a colorless viscous liquid, the fixing cartridge is formed into the nozzle, adjust the printing pressure, and control the nozzle. Extruded, the shape is circular, the size is 400um, and the size of the print platform is maintained at 100 ° C during the printing process to enhance the crosslinking between the lines and the lines; print the height of 800um, diameter The high-density polyethylene porous bracket of 10 mm; the...

Embodiment 2

[0064] A method for preparing high density polyethylene surface modified composite brackets, including the following steps:

[0065] S1, use the SOL IDWORKS software to draw a cylinder of 10mm in diameter, stored in STL format; open nitrogen, 3D printer, Perfactory RP slice software, after sesame model Import 3D printer control software VisulMachines, operation 3D control software gives print nozzle 180 The high temperature of ° C is placed in the spray head, and a high density polyethylene (HDPE) powder is added, and after the matrix material is melted into a colorless viscous liquid, the fixing cartridge is formed into the nozzle, adjust the printing pressure, and control the nozzle. Extruded, the shape of the line to be extruded is performed when the size is 500um; the temperature of the print platform is maintained at 80 ° C during the printing process to enhance the degree of crosslinking between the lines and the lines; print the height of 800um, diameter The high-density po...

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Abstract

The invention discloses a high-density polyethylene surface-modified composite scaffold as well as a preparation method and application thereof. The method comprises the following steps: S1, preparing an HDPE porous scaffold through a 3D printing technology by taking HDPE powder as a base material; S2, carrying out ultrasonic cleaning, drying and plasma cleaning on the HDPE porous scaffold, then dipping the HDPE porous scaffold in a dopamine solution for PDA modification on the surface of the scaffold, and carrying out drying to obtain a PDA / HDPE composite scaffold; S3, soaking the PDA / HDPE composite scaffold in an SBF simulated body fluid to form a bone-like hydroxyapatite layer on the surface of the PDA / HDPE composite scaffold, and carrying out cleaning and drying to obtain a PDA / HA / HDPE composite scaffold; and S4, soaking the PDA / HA / HDPE composite scaffold in a VEGF-loaded microsphere solution for modification, and carrying out cleaning and drying to obtain the PDA / HA / VEGF / HDPE composite scaffold. According to the application, the prepared high-density polyethylene surface-modified composite scaffold is used as a cranio-maxillofacial bone defect repair material. The high-density polyethylene surface-modified composite scaffold prepared by the invention has personalized characteristics and good biological activity and body bone tissue integration performance, and the preparation method disclosed by the invention is simple and effective in process.

Description

Technical field [0001] The present invention relates to the technical field of medical materials, and more particularly to a high density polyethylene surface modified composite stent and a preparation method thereof. Background technique [0002] Various factors such as trauma, infection, tumor resection or congenital malformation disrupt the continuity and integrity of the skull skeleton, resulting in an abnormal or dysfunction of the appearance of the skull and mandiblerome, which seriously affects the quality of life of the patient. Due to high-density polyethylene (HDPE), biocompatibility, plasticity, chemical stability, and excellent mechanical properties, hot press-molded high-density polyethylene (MedPor) is repaired by craniofalancing. It is widely used in the defect reconstruction and reinforcement of intranonomous skeletals such as cranial, eyelid, 颧 and mandible. However, high-density polyethylene (HDPE) does not have biologically active, and MEDPOR implant hot press ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J9/40C08L23/06C08L79/04C08K3/32C08K9/10A61L27/16A61L27/18A61L27/20A61L27/22A61L27/32A61L27/50A61L27/54A61L27/56
CPCC08J9/405C08J9/40A61L27/16A61L27/18A61L27/32A61L27/54A61L27/56A61L27/227A61L27/20A61L27/50A61L2430/02A61L2300/414A61L2300/602C08J2323/06C08J2479/04C08K2003/325C08K9/10C08L23/06C08L79/04C08L89/00C08L5/08Y02P10/25
Inventor 黄文华朱晶吴耀彬王杰杰殷俊飞扬汪艳芳
Owner CHANGZHOU HUALIAN HEALTH DRESSING LTD