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Paecilomyces hepialid strain fermentation composition as well as preparation method and application thereof

A technology of Paecilomyces spp. and a fermented composition is applied to the application field of Paecilomyces spp. bats, which can solve the problems of complicated brewing procedures of traditional Chinese medicines, inability to produce efficiently, and a long treatment course for curative effects, and achieves the improvement of metabolic capacity, The effect of promoting microcirculation and endocrine disorders in the body

Inactive Publication Date: 2021-12-03
无锡康能特医食品科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The existing gynecological drugs only have a single function due to the limitation of the prescription, and the existing gynecological drugs for the treatment of gynecology are equipped with chemicals with very few side effects. Although the effect is relatively fast, short-term recurrence is very common
It is best to use pure Chinese medicine prescriptions for treatment, but the curative course of using pure Chinese medicine gynecological medicines will be very long, and it cannot be cured; and the procedure of boiling Chinese medicine is complicated, the time is limited, and it cannot be produced efficiently

Method used

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  • Paecilomyces hepialid strain fermentation composition as well as preparation method and application thereof
  • Paecilomyces hepialid strain fermentation composition as well as preparation method and application thereof
  • Paecilomyces hepialid strain fermentation composition as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] Source of strain: Paecilomyces hepiali No. 3.15540 was purchased from China General Microbiology Collection Center, Institute of Microbiology, Chinese Academy of Sciences. The preservation time is February 19, 2016. The culture temperature is 25°C, the collection country: China, and the collection location: Yushu, Qinghai.

[0047] A preparation method of a Paecilomyces hematoptera strain fermentation composition, said method comprising the steps of:

[0048] S1. Select the Paecilomyces hematalis powder according to the corresponding proportion, add water and disperse it, and inoculate it with an inoculation amount of 5 wt%. The Paecilomyces hematalis powder dispersion solution is inoculated, at first utilize slant culture (cultivation process is: slant medium: 10wt% potato+1wt% glucose+0.8wt% peptone+0.1wt%KH 2 PO 4 +0.05wt%MgSQ 4 ·7H 2 0+2wt% agar, pH: 5.0-7.5; Culture medium sterilization: 0.1MPa, 20 minutes; Paecilomyces hematodes powder is dispersed with water...

Embodiment 2

[0054] Strains: Paecilomyces sinensis No.5.825 was purchased from the China General Microorganism Collection and Management Center, Institute of Microbiology, Chinese Academy of Sciences. The preservation time is January 1, 2002. The culture temperature is 25°C, the collection country: China, and the collection location: Shaanxi.

[0055] A preparation method of a Paecilomyces hematoptera strain fermentation composition, said method comprising the steps of:

[0056] S1. Select the Paecilomyces hematalis powder according to the corresponding proportion, add water and disperse it, and inoculate it with an inoculum amount of 20wt%. The Paecilomyces spp. bat moth powder dispersion solution is inoculated, at first utilize slant culture (cultivation process is: slant medium: 20wt% potato+2wt% glucose+1wt% peptone+0.1wt%KH 2 PO 4 +0.05wt%MgSQ 4 ·7H 2 0+4wt% agar, pH: 5.0-7.5; Culture medium sterilization: 0.2MPa, 30 minutes; Paecilomyces hematodes powder is dispersed with water ...

experiment example

[0062] The amount of formula used is 400 parts of flaxseed concentrated powder, 200 parts of double-petal red rose pollen, 200 parts of gamma-aminobutyric acid, 300 parts of red ginseng powder, 300 parts of red date powder, 300 parts of wolfberry powder, 300 parts of cranberry powder and 600 parts of Paecilomyces bat moth powder. The finished solid particles obtained by the preparation method of Example 2 were used as experimental reagents.

[0063] Ways to volunteer to experience efficacy:

[0064] (1) Inclusion criteria: 20-60-year-old women, no history of obvious cardiovascular and cerebrovascular diseases, no clear complications of diabetes.

[0065] (2) Dosage: 1-2 bags (2 grams / bag) each time, once a day, it is recommended to take after dinner. Take it for 21 consecutive days (avoid taking it during menstruation).

[0066] Experience result statistics method:

[0067]

[0068]

[0069]

[0070] Remarks: Symptom change and result judgment: Result judgment: No...

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Abstract

The invention belongs to the technical field of application of paecilomyces hepialid strains, and discloses a paecilomyces hepialid strain fermentation composition as well as a preparation method and application thereof. SDG in the flaxseed lignan is converted into SECO through the desugaring effect of beta-glucosidase in a culture solution obtained after fermentation of the paecilomyces hepialid strains, the SECO is easier to absorb, and the bioavailability of the flaxseed lignan is promoted to be improved to 75% from 15%; and under the action of [beta]-glucosidase, various glycosides or glycosides in the double-petal red roses, [gamma]-aminobutyric acid, red ginseng, red dates, Chinese wolfberry fruits and cranberries can be converted into aglycones, the aglycones are easily absorbed by a human body, and the bioavailability of effective components in the raw materials is promoted to be remarkably improved. The paecilomyces hepialid strain fermentation composition has the effects of replenishing blood, activating blood, reinforcing qi, nourishing liver, improving metabolism, promoting microcirculation in the body, accelerating internal circulation and conditioning female endocrine dyscrasia, so as to improve the syndrome caused by female estrogen reduction.

Description

technical field [0001] The invention belongs to the technical field of application of Paecilomyces spp., in particular to a fermented composition of Paecilomyces spp. and its preparation method and application. Background technique [0002] In a normal human body, the endocrine system and the nervous system regulate metabolism and physiological functions in the body. The endocrine system participates in regulating many physiological activities such as metabolism, growth and development, reproductive aging, etc. of the human body by secreting various hormones, and cooperates with various biological enzymes to maintain Relative stability of the internal environment of the human body to adapt to complex and changeable internal and external changes. When the endocrine system of the human body is disturbed, it will cause corresponding clinical manifestations, especially for women, because they have special physiological processes such as meridian, vaginal delivery, pregnancy, and...

Claims

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Application Information

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IPC IPC(8): A61K36/815A61K9/14A61P5/00A61P5/30C12P1/02A61K31/197C12R1/79
CPCA61K36/55A61K36/738A61K31/197A61K36/258A61K36/725A61K36/815A61K36/45A61K36/06A61K9/14A61P5/00A61P5/30C12P1/02A61K2236/19A61K2300/00
Inventor 袁岚马志民徐连明
Owner 无锡康能特医食品科技有限公司
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