A kind of polycaprolactone microsphere and its preparation method and application
A kind of polycaprolactone, microsphere technology
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[0038] In a specific embodiment, the preparation method of the polycaprolactone microspheres described above comprises:
[0039] Contacting the aqueous solution of hydroxypropyl methylcellulose and the dichloromethane solution of polycaprolactone and performing shear emulsification simultaneously to form a shear emulsified mixture;
[0040] The polyvinyl alcohol aqueous solution is contacted with the shear emulsification mixture and heated until the dichloromethane volatilizes completely;
[0041] Filter to obtain microspheres ranging from 28 μm to 100 μm.
[0042] In a specific embodiment, the sheared emulsification system is also added with poloxamer, and the mass ratio of hydroxypropyl methylcellulose to poloxamer is 2: (0.5-5), such as 2 :0.5, 2:1, 2:1.5, 2:2, 2:2.5, 2:3, 2:3.5, 2:4, 2:4.5 or 2:5. During the microsphere shearing process, poloxamer acts as an emulsifier and stabilizer, improving the stability of the emulsion system is more conducive to the formation of po...
Embodiment 1
[0052] In the present embodiment, the preparation of 0.2wt% hydroxypropylmethylcellulose (HPMC) solution comprises the following steps:
[0053] Take 1000mL of water for injection and add it to the beaker, heat it to 80°C in a water bath, and stir at 250rpm;
[0054] Weigh 5g of HPMC and 2.5g of poloxamer, add them into the beaker, stir for 4h to dissolve completely, turn off the water bath to heat, continue to stir for 2h, and cool to room temperature;
[0055] Add the prepared solution to 1500mL water for injection to dilute and stir evenly, and filter the impurities with a 0.22μm filter membrane. Store at 2-8°C.
[0056] In the present embodiment, the preparation of 5wt% polyvinyl alcohol solution comprises the following steps:
[0057] Add 400mL of water for injection into a glass bottle, heat to 100°C in a water bath, and start stirring at 150-600rpm;
[0058] Weigh 25g of PVA into the bottle, stir for 5h until completely dissolved;
[0059] Add 100mL of water for inj...
Embodiment 2
[0080] In the present embodiment, the preparation of 0.5wt% hydroxypropylmethylcellulose (HPMC) solution comprises the following steps:
[0081] Take 1000mL of water for injection and add it to the beaker, heat it to 80°C in a water bath, and stir at 250rpm;
[0082] Weigh 12.5g of HPMC and 5g of poloxamer, add them into a beaker, stir for 4h to dissolve completely, turn off the water bath to heat, continue to stir for 2h, and cool to room temperature;
[0083] Add the prepared solution to 1500mL water for injection to dilute and stir evenly, and filter the impurities with a 0.22μm filter membrane. Store at 2-8°C.
[0084] In the present embodiment, the preparation of 3wt% polyvinyl alcohol solution comprises the following steps:
[0085] Add 400mL of water for injection into a glass bottle, heat to 100°C in a water bath, and start stirring at 150-600rpm;
[0086] Weigh 15g of PVA into the bottle, stir for 5h until completely dissolved;
[0087] Add 100mL of water for inje...
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