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Modified hydroxypropyl chitosan adhesive self-healing hydrogel as well as preparation method and application thereof

A technology of hydroxypropyl chitosan and hydrogel, which is applied in the field of functional polymers, can solve problems such as easy damage, and achieve the effects of good swelling performance, easy industrialization, excellent adhesion and self-healing performance

Pending Publication Date: 2021-12-31
WUHAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, hydroxypropyl chitosan hydrogel texture is brittle, easily damaged, and itself has no adhesiveness. Therefore, developing a modified hydroxypropyl chitosan hydrogel with both adhesion and self-healing functions has important practical significance

Method used

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  • Modified hydroxypropyl chitosan adhesive self-healing hydrogel as well as preparation method and application thereof
  • Modified hydroxypropyl chitosan adhesive self-healing hydrogel as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] 1) Weigh 1 g of hydroxypropyl chitosan and dissolve it in 100 mL of deionized water, stir magnetically at room temperature until it dissolves evenly, and adjust the pH to 5.6.

[0044] 2) Another 1g of caffeic acid was weighed and dissolved in 40mL of ethanol aqueous solution (deionized water: absolute ethanol = 1:1), magnetically stirred until dissolved evenly, and then 2g of 1-(3-dimethylaminopropyl)- 3-Ethylcarbodiimide hydrochloride was activated for 2 hours, then added to the above-mentioned hydroxypropyl chitosan solution, and reacted for 24 hours under the protection of nitrogen and protected from light.

[0045] 3) The obtained crude product was dialyzed in deionized water for 3 days, and dried to obtain caffeic acid-modified hydroxypropyl chitosan derivatives.

[0046] 4) Weigh 267mg of caffeic acid-modified hydroxypropyl chitosan derivative into a beaker, add 3mL of deionized water, and magnetically stir until it dissolves evenly.

[0047]5) Weigh 80mg of acr...

Embodiment 2

[0053] 1) Weigh 1 g of hydroxypropyl chitosan and dissolve it in 100 mL of deionized water, stir magnetically at room temperature until it dissolves evenly, and adjust the pH to 5.6.

[0054] 2) Another 1g of caffeic acid was weighed and dissolved in 40mL of ethanol aqueous solution (deionized water: absolute ethanol = 1:1), magnetically stirred until dissolved evenly, and then 2g of 1-(3-dimethylaminopropyl)- 3-Ethylcarbodiimide hydrochloride was activated for 2 hours, then added to the above-mentioned hydroxypropyl chitosan solution, and reacted for 24 hours under the protection of nitrogen and protected from light.

[0055] 3) The obtained crude product was dialyzed in deionized water for 3 days, and dried to obtain caffeic acid-modified hydroxypropyl chitosan derivatives.

[0056] 4) Weigh 160 mg of caffeic acid-modified hydroxypropyl chitosan derivative into a beaker, add 3 mL of deionized water, and stir magnetically until it dissolves evenly.

[0057] 5) Weigh 80mg of ...

Embodiment 3

[0061] 1) Weigh 1 g of hydroxypropyl chitosan and dissolve it in 100 mL of deionized water, stir magnetically at room temperature until it dissolves evenly, and adjust the pH to 5.6.

[0062] 2) Another 1g of caffeic acid was weighed and dissolved in 40mL of ethanol aqueous solution (deionized water: absolute ethanol = 1:1), magnetically stirred until dissolved evenly, and then 2g of 1-(3-dimethylaminopropyl)- 3-Ethylcarbodiimide hydrochloride was activated for 2 hours, then added to the above-mentioned hydroxypropyl chitosan solution, and reacted for 24 hours under the protection of nitrogen and protected from light.

[0063] 3) The obtained crude product was dialyzed in deionized water for 3 days, and dried to obtain caffeic acid-modified hydroxypropyl chitosan derivatives.

[0064] 4) Weigh 160 mg of caffeic acid-modified hydroxypropyl chitosan derivative into a beaker, add 3 mL of deionized water, and stir magnetically until it dissolves evenly.

[0065] 5) Weigh 120mg of...

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Abstract

The invention discloses modified hydroxypropyl chitosan adhesive self-healing hydrogel as well as a preparation method and application thereof. The preparation method comprises the following steps of: chemically modifying hydroxypropyl chitosan with caffeic acid; performing modifyingwith composite acrylamide; performing cross-linking with a mixed cross-linking agent of oxidized konjac glucomannan and N, N '-methylene bisacrylamide; and finally preserving heat to obtain the modified hydroxypropyl chitosan adhesive self-healing hydrogel. The hydrogel has excellent adhesion, self-healing, mechanical and swelling properties. By introducing the acrylamide, the adhesion property of the adhesive self-healing hydrogel is improved to 2.66 times, and the mechanical property of the adhesive self-healing hydrogel is improved to 2.4 times. With the hydrogel of the invention adopted, the problems of insufficient adhesion, self-healing and mechanical properties of a traditional hydroxypropyl chitosan hydrogel are solved.

Description

technical field [0001] The invention relates to the technical field of functional polymers, in particular to a modified hydroxypropyl chitosan adhesive self-healing hydrogel and its preparation method and application. Background technique [0002] As a functional material, hydrogel has broad application prospects in the fields of biomedical materials, chemical engineering, environmental engineering, and agriculture. However, hydrogels generally have no adhesion, which makes it inconvenient to use in some specific occasions. For example, in surgical operations, wound closure and repair is one of the key issues, and the traditional suturing method has many shortcomings. The method of adhesive hydrogel has become a potential development direction, which has attracted widespread attention all over the world, and its market prospect is huge. [0003] In addition, hydrogels are usually easily damaged, resulting in functional failure of the material and requiring frequent replacem...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/075C08F251/00C08F220/56C08F222/38C08L5/08C08L33/26C08L5/00A61L24/00A61L24/06A61L24/08A61L26/00
CPCC08J3/075C08F251/00A61L26/008A61L26/0023A61L24/0031A61L24/08A61L26/0014A61L24/06C08J2305/08C08J2433/26C08J2405/00C08F220/56C08F222/385
Inventor 何广华宁校庆陈晓静陈秀昊卢昆樊李红郭远东
Owner WUHAN UNIV OF TECH
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