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Method for preparing smearing agent by using N-acetylglucosamine mother liquor

A technology of glucose mother liquid and acetyl amino, which is applied in the preparation of amino sugar and sugar derivatives, chemical instruments and methods, etc., to achieve huge economic value, improve absorption effect, and improve bone density

Pending Publication Date: 2022-01-07
SHANDONG RUNDE BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

How to effectively utilize N-acetylglucosamine, and in what form is it used by people, there are few related reports

Method used

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  • Method for preparing smearing agent by using N-acetylglucosamine mother liquor
  • Method for preparing smearing agent by using N-acetylglucosamine mother liquor

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Embodiment 1: N-acetylglucosamine mother liquor preparation

[0032] (1) Adjust the pH of the N-acetylglucosamine fermentation broth to 4.0 with concentrated sulfuric acid.

[0033] (2) Rapidly heat up the N-acetylglucosamine fermentation broth prepared at pH 4.0 to 85°C with high-temperature steam, and inactivate the bacteria for 30 minutes to ensure the inactivation of the bacteria and facilitate the denaturation and precipitation of miscellaneous proteins.

[0034] (3) Filtrate with a ceramic membrane (pore size: 40 nm), and collect the filtrate.

[0035] (4) Add activated carbon and diatomaceous earth to the collected filtrate to decolorize and collect the decolorized solution. The mass ratio of activated carbon to diatomaceous earth is 1:1, and the mass ratio of filtrate to activated carbon is 100:1.

[0036] (5) The electrodialysis desalination adopts dense homogeneous ion exchange membrane, the volume ratio of the desalination chamber and the concentration cham...

Embodiment 2

[0038] Embodiment 2: Radix Angelicae Sinensis Extract

[0039] After crushing Angelica sinensis, mix it with water at a mass ratio of 1:5, and extract it with water at 100°C for 30 minutes, then add 3 times the mass of warm water at 60°C to the filtered residue, and extract it with water at 100°C for 15 minutes. The filtrates obtained by water extraction were mixed. The filtrate was rotary evaporated at 80° C. under a vacuum of 0.08 MPa until the relative density reached 1.26. The obtained thick paste is the angelica extract.

Embodiment 3

[0041] Mix 30 g of the N-acetylglucosamine mother liquor prepared in Example 1, 3 g of menthol, 7.5 g of the angelica extract prepared in Example 2, and 7.5 g of Panax notoginseng powder to obtain a spread.

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Abstract

The invention discloses a method for preparing a smearing agent by using N-acetylglucosamine mother liquor. Active components of the smearing agent comprise the following raw materials in parts by weight: 20 to 40 parts of N-acetylglucosamine mother liquor, 2 to 4 parts of menthol, 5 to 10 parts of radix angelicae sinensis extract and 5 to 10 parts of radix notoginseng powder. The N-acetylglucosamine mother liquor is obtained by adjusting the pH value of N-acetylglucosamine fermentation liquor, sterilizing, and then sequentially carrying out ceramic membrane filtration, decoloration, electrodialysis desalination and concentration. According to the invention, the N-acetylglucosamine mother liquor is prepared into the smearing agent, and meanwhile, the menthol and the radix angelicae sinensis extract are supplemented, so that not only can the absorption of the N-acetylglucosamine be promoted, but also a synergistic effect is achieved on improvement of the bone mineral density and treatment of arthralgia, and the application of the N-acetylglucosamine is further widened.

Description

technical field [0001] The invention relates to the technical field of joint medicines, in particular to a method for preparing an ointment by using N-acetylglucosamine mother liquor. Background technique [0002] At present, N-acetylglucosamine (GlcNAc) is fermented by genetically engineered bacteria, and its fermentation liquid is filtered to remove impurities, separated and purified, and refined to obtain glucosamine hydrochloride or glucosamine sulfate powder. Since domestic manufacturers and downstream products mainly use glucosamine hydrochloride or glucosamine hydrochloride, N-acetyl glucosamine is relatively rare in final products, so N-acetyl glucosamine is rare in common consumer products. The process steps for preparing glucosamine hydrochloride are long, the quality control is difficult, and the amount of waste water generated in the preparation process is large, which is not conducive to environmental protection and energy saving and emission reduction. [0003...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7008A61K31/045A61K36/258A61K9/00A61P19/02A61P29/00A61P19/10C07H1/06C07H5/06
CPCA61K31/7008A61K31/045A61K36/232A61K36/258A61K9/0014A61P19/02A61P29/00A61P19/10C07H1/06C07H5/06A61K2300/00
Inventor 卢健行梁剑光蒋萧韩宁张建华巩凤英
Owner SHANDONG RUNDE BIOTECH CO LTD
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