Kit for detecting four psychiatric drugs and metabolites thereof in vivo

Abstract

The invention provides a kit for detecting four psychiatric drugs or metabolites thereof in an in-vivo biological sample, wherein the kit comprises: (1) a mixed standard solution TDM detection tube, of which the preparation method comprises: adding an internal standard solution and a mixed standard solution into the TDM detection tube, and drying the tube; and (2) a sample solution detection TDM detection tube, of which a preparation method comprises the following steps: adding the internal standard solution into the TDM detection tube, and drying the tube; (3) a reconstitution solution being a methanol-water solution containing formic acid; (4) a specification, recording a use method of the kit. The kit is stored at the temperature of -20 to -15 DEG C. Liquid-liquid extraction and an internal standard UPLC-UV method are adopted, and separation of common psychiatric drugs and active metabolites thereof in human serum or hair is achieved; the mobile phase is free of salt additives, so that switching of different methods is facilitated. Therefore, the kit has good clinical detection value and economic significance while the detection time is greatly shortened, and has good application prospects.

Description

technical field [0001] The invention relates to the field of detection of blood concentration of psychiatric drugs, in particular to a kit for detecting four psychiatric drugs and their metabolites in vivo. Background technique [0002] Antipsychotic drugs, also known as strong tranquilizers or neuroleptics, are a group of drugs used to treat schizophrenia and other psychotic disorders. The usual therapeutic dose does not affect the patient's intelligence and consciousness, but it can effectively control the patient's psychomotor excitement, hallucinations, delusions, hostility, thinking disorders and abnormal behaviors and other mental symptoms. Patients usually have sleep disorders and often take sedative and tranquillizing drugs at the same time. However, in order to monitor the blood concentration of therapeutic drugs in patients, at least these drugs need to be separated to avoid interference. [0003] Aripiprazole is used in the treatment of various forms of schizophr...

AI Technical Summary

Problems solved by technology

Because clinical patients often take a variety of drugs for basic mental diseases at the same time, the chromatographic separation of drugs is often not fully realized by the high performance liquid chromatography ultraviolet detection method, which is prone to interference and affects the quantitative results; the high performance liquid chromatography tandem mass spectrometry As a detection method, it is a powerful anal

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