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Synthetic method of ergosterol and derivatives thereof

A technology for ergosterol and a synthetic method, applied in the field of synthesis of ergosterol and derivatives thereof, can solve the problems such as no relevant route reports, difficulty in extraction and separation, large amount of waste water, etc., and achieves short process route, wide raw material sources, total high yield effect

Active Publication Date: 2022-02-08
HUNAN KEREY BIOTECH
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

[0003] The current method of producing ergosterol is to extract from the cultured yeast, and extract ergosterol after cultivating the yeast cell, the yield is very low, and the amount of waste water is large, and the ergosterol extracted by this method contains other homologues, which need to be extracted and separated relatively difficult
[0004] At present, there is no relevant route report for mature synthesis

Method used

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  • Synthetic method of ergosterol and derivatives thereof
  • Synthetic method of ergosterol and derivatives thereof
  • Synthetic method of ergosterol and derivatives thereof

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Embodiment Construction

[0049] In the following description, numerous specific details are set forth in order to provide a thorough understanding of the present invention. However, the present invention can be implemented in many other ways different from those described here, and those skilled in the art can make similar improvements without departing from the connotation of the present invention, so the present invention is not limited by the specific implementations disclosed below.

[0050] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the technical field of the invention. The terms used herein in the description of the present invention are for the purpose of describing specific embodiments only, and are not intended to limit the present invention.

[0051] 1. Preparation of Wittig reagent

[0052] Taking isovaleraldehyde (compound A0) as raw material, the concrete route is as follows:

[0053] ...

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Abstract

The invention discloses a synthetic method of ergosterol and derivatives thereof, which comprises the following steps: by taking a compound V as a raw material, carrying out side chain formylation and wittig reaction to obtain ergosterol and derivatives thereof. The structure formula of the compound V is shown in the specification. The invention provides the novel preparation method of ergosterol and derivatives thereof, the ergosterol is obtained in a synthesis manner, a target structure can be obtained in a targeted manner, the yield is high, and the purity is high. In addition, the synthetic route is short and environment-friendly, and is suitable for industrial production.

Description

technical field [0001] The invention relates to the technical field of chemical synthesis of medicines, more specifically, to a method for synthesizing ergosterol and derivatives thereof. Background technique [0002] Ergosterol is a precursor for the production of vitamin D2 and an intermediate in the production of hormone drugs, which can be converted into vitamin D2 under ultraviolet light. Ergosterol is a plant sterol found in fungal yeasts and ergots. It is an important part of microbial cell membranes and plays an important role in ensuring the integrity of cell membranes, the spark of membrane-bound enzymes, the fluidity of membranes, cell viability and cell substances. Transport etc. play an important role. Studies have shown that ergosterol may have antitumor properties. [0003] The current method of producing ergosterol is to extract from the cultured yeast, and extract ergosterol after cultivating the yeast cell, the yield is very low, and the amount of waste w...

Claims

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Application Information

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IPC IPC(8): C07J9/00
CPCC07J9/00C07J9/005Y02P20/55
Inventor 李凯唐杰谢来宾
Owner HUNAN KEREY BIOTECH
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