Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Pharmaceutical composition with synergistic analgesic effect

A composition and drug technology, which is applied in the direction of drug combination, active ingredients of hydroxyl compounds, medical preparations containing active ingredients, etc., can solve problems such as side effects, inability to meet analgesic needs, and dose limitations, so as to reduce the dosage and avoid Effect of Adverse Reaction, Compliance and Tolerability Guarantee

Pending Publication Date: 2022-02-18
JIANGSU OCEAN UNIV
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, because single drugs of gabapentin or duloxetine often cannot meet the analgesic needs, provide only partial relief, or have dose-limiting side effects

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Pharmaceutical composition with synergistic analgesic effect
  • Pharmaceutical composition with synergistic analgesic effect
  • Pharmaceutical composition with synergistic analgesic effect

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] This example is an evaluation of the analgesic effect of resveratrol and gabapentin or duloxetine in a paclitaxel-induced mouse model of neuralgia

[0033] In the paclitaxel-induced neuropathic pain model in mice, the mechanical paw withdrawal threshold of the mice before and after administration was measured by the plantar tenderness instrument to evaluate the effect of resveratrol combined with gabapentin and duloxetine on mechanical allodynia analgesic effect. For 5 consecutive days, female mice were intraperitoneally injected with paclitaxel 2 mg / kg·d to establish a model of paclitaxel-induced neuralgia in mice. The mechanical paw withdrawal threshold of the mice was measured using a plantar tenderness instrument. When the mice showed positive reactions such as lifting and licking the feet, it was the mechanical paw withdrawal threshold. The measured mechanical paw withdrawal threshold was recorded in grams, and the hind paw of each mouse was tested 3 times with an...

Embodiment 2

[0038] This example is an evaluation of the analgesic effect of resveratrol and gabapentin or duloxetine in the mouse acetic acid writhing model

[0039] Female mice were weighed and randomly divided into control group, model group, resveratrol group (200 mg / kg), gabapentin group (50, 100, 200 and 300 mg / kg), duloxetine group (5, 10 , 20 and 30mg / kg) and combined medication (gabapentin 50mg / kg+resveratrol 200mg / kg, duloxetine 5mg / kg+resveratrol 200mg / kg) and other 13 groups (n=8). In the resveratrol group, the mice were intragastrically administered resveratrol 200 mg / kg, and the time interval between intraperitoneal injection of 1% acetic acid solution was 10 minutes. In the gabapentin group and the duloxetine group, different doses of gabapentin and duloxetine were injected intraperitoneally to the mice, respectively, and the time interval between the intraperitoneal injection of 1% acetic acid solution to the mice was 30 minutes. Observe and record the number of writhing t...

Embodiment 3

[0043] This example is an evaluation of the analgesic effect of resveratrol and gabapentin or duloxetine in a formalin-induced pain model in rats

[0044] Male rats were weighed and randomly divided into control group, model group, resveratrol group (300 mg / kg), gabapentin group (100, 200, 300 and 400 mg / kg), duloxetine group (10, 14 , 15 and 25mg / kg) and combined medication (gabapentin 100mg / kg+resveratrol 300mg / kg, duloxetine 14mg / kg+resveratrol 300mg / kg) and other 13 groups (n=8).

[0045] Before the experiment, the rats were placed in the experimental apparatus for 60 minutes to fully adapt to the experimental environment. In the resveratrol group, the rats were given resveratrol 300 mg / kg orally, and the time interval between subcutaneous injection of 100 μL of 5% formalin solution to the plantar of the rat's hind paw was 10 minutes. In the gabapentin group, different doses of gabapentin were given to the rats by intragastric administration, and the time interval between...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention belongs to the technical field of medicines, and particularly relates to a pharmaceutical composition with a synergistic analgesic effect, and the pharmaceutical composition comprises resveratrol and one of gabapentin and duloxetine. According to the invention, resveratrol and gabapentin or duloxetine are combined for medication, a large number of experimental studies show that the combined medication can generate a very obvious synergistic analgesic effect, and experiments show that the dose combination does not affect the movement balance ability and muscle coordination of an acting object. Therefore, the analgesic effect of the combination of the resveratrol and the gabapentin or duloxetine is superior to that of the gabapentin or duloxetine which is independently used, so that the pharmaceutical composition has a better application prospect; in addition, the use dosage of gabapentin or duloxetine can be greatly reduced through pharmaceutical composition, guarantee is provided for compliance and tolerance of clinical medication, and adverse reactions of gabapentin or duloxetine are reduced or avoided.

Description

technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to a pharmaceutical composition with synergistic analgesic effect. Background technique [0002] Analgesics are the most commonly used and basic therapy for pain relief. At present, although the main drugs for clinical treatment of pain have played a huge role in alleviating the pain of patients, they all have serious adverse reactions. Combination medication is the use of drugs with different mechanisms of action to intervene in multi-level pain perception or transmission, reduce the body's pain perception, and make its analgesic effects additive or synergistic. Combination medication can achieve the ideal analgesic effect while avoiding the adverse reactions of dose limitation caused by the use of a single drug. [0003] Gabapentin belongs to the calcium ion channel modulator, mainly through the α 2 The combination of -δ subunit protein and N-methyl-D-aspartic aci...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K31/196A61K31/381A61P29/00A61K31/05
CPCA61K31/05A61K31/196A61K31/381A61P29/00A61K2300/00
Inventor 陈寅徐君怡庄涛
Owner JIANGSU OCEAN UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com