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Terahertz time-domain spectrum probe device for biomedical imaging and time-domain spectrometer

A terahertz time-domain and biomedical technology is applied in the field of terahertz time-domain spectroscopic probe devices and time-domain spectrometers, which can solve the problems of low signal-to-noise ratio of terahertz spectral images, long two-dimensional scanning time, and unsatisfactory handheld functions. Achieve the effect of improving spectral imaging efficiency, easy and fast positioning, and reducing transmission loss

Pending Publication Date: 2022-03-11
博微太赫兹信息科技有限公司 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to solve the problem that the existing terahertz time-domain spectral imaging device has a low signal-to-noise ratio and cannot be miniaturized due to serious transmission loss, long two-dimensional scanning time, and bulky detection head. , does not satisfy the problem of hand-held functions, and provides a terahertz time-domain spectroscopy probe device and time-domain spectrometer for biomedical imaging

Method used

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  • Terahertz time-domain spectrum probe device for biomedical imaging and time-domain spectrometer
  • Terahertz time-domain spectrum probe device for biomedical imaging and time-domain spectrometer
  • Terahertz time-domain spectrum probe device for biomedical imaging and time-domain spectrometer

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Embodiment 1

[0036] This embodiment provides a terahertz time-domain spectroscopy probe device for biomedical imaging, such as figure 1 As shown, terahertz wave transmitting photoconductive antenna 2, transmitting end off-axis parabolic mirror 3, scanning parabolic mirror 4, TPX material wedge window 5, scanning translation stage 6, detecting end off-axis parabolic mirror 7, terahertz wave detecting photoelectric Guide antenna 8.

[0037] said figure 1 The terahertz emission and detection photoconductive antenna is placed on the focal point of the emission and focusing parabola; the emission and detection parabola is an off-axis 90° parabola, the reflection focal length is 33mm, and its reflection surface is coated with gold; the scanning The parent focal length of the parabolic mirror is 33.5mm, and its reflective surface is coated with gold, half of which is used. The effective containment angle is 48°, and the reflective focal length is 1.7 times of the incident focal length.

[0038]...

Embodiment 2

[0040] This embodiment provides a terahertz time-domain spectrometer for biomedical imaging, such as Figure 1~2 As shown, it includes a terahertz time-domain spectrometer body 1, a terahertz wave emitting photoconductive antenna 2, an off-axis parabolic mirror 3 at the transmitting end, a scanning parabolic mirror 4, a TPX material wedge window 5, a scanning translation stage 6, and an off-axis detecting end Parabolic mirror 7, terahertz wave detection photoconductive antenna 8, industrial computer 9, mounting seat 16, shell and base 11, these components are firmly installed in the base with ribbed structure. Scanning stage 6 through 2 The cylindrical pin positioning, four M5 inner hexagonal screws are fastened and installed on the bottom of the base 15, the mounting seat 16 is installed on the scanning displacement table 6 through four M4 inner hexagonal screws, and the scanning parabolic mirror 4 uses balls as joints. 2. Pulling and 2 tightening are used to adjust and fix ...

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Abstract

The invention relates to a terahertz time-domain spectroscopy probe device for biomedical imaging and a time-domain spectrometer, a terahertz time-domain spectrometer body excites and emits terahertz waves emitted by a photoconductive antenna, the terahertz waves are collimated by an off-axis parabolic mirror at a transmitting end, and the collimated terahertz waves are focused on the surface of a sample by a scanning parabolic mirror; a focusing light spot is reflected by the sample, is collimated by the scanning parabolic mirror again and is focused on an electrode of the detection photoconductive antenna by the detection parabolic mirror, terahertz waves are converted into time-domain electric signals by the terahertz time-domain spectrometer, the time-domain electric signals are collected and stored under the control of the industrial personal computer, and the time-domain signals are further analyzed; the scanning mode is realized in a way that a one-dimensional electric displacement platform drives a scanning parabolic mirror to do reciprocating motion, point-by-point sampling is carried out, and scanning with a line width of 16mm can be realized within one second through a high-speed acquisition card; the problems that the signal-to-noise ratio of a terahertz spectral image of a sample finally obtained by an existing terahertz time-domain spectral imaging device is low, miniaturization cannot be achieved, and the handheld function cannot be met are solved.

Description

technical field [0001] The invention relates to the technical field of terahertz, in particular to a terahertz time-domain spectrum probe device and time-domain spectrometer for biomedical imaging. Background technique [0002] Terahertz (THz) waves refer to electromagnetic waves with a frequency of 0.1-10 THz between infrared and microwave, which have the characteristics of non-ionization, fingerprint spectrum and sensitivity to polar substances. As one of the candidate technologies for medical imaging, terahertz time-domain spectral imaging has great application potential in the fields of skin burns, dental tissue detection, postoperative diagnosis, and detection and identification of many tumor lesions. The difference in water content is the main reason for the difference in THz spectrum between tumor and normal tissue. The higher water content of tumor tissue and the increase of tumor cell density, nuclear atypia, and mitotic activity will change its detection in THz ban...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/3586
CPCG01N21/3586
Inventor 杨伟锋叶加良胡其枫郭国祯汪仁杰郭好雨
Owner 博微太赫兹信息科技有限公司
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