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Coating

A coating preparation and coating technology, applied in coatings, devices for coating liquids on surfaces, and pharmaceutical formulations, can solve problems such as platelet activation, difficulty in vascular navigation, and thrombosis

Pending Publication Date: 2022-03-11
MICROVENTION INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These high friction forces make vessel navigation difficult
In addition, prolonged blood exposure can lead to thrombosis, protein adsorption, and platelet activation

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0091] Preparation of primer polymer

[0092] Into a 1 L round bottom flask was charged 80.0 g tetrahydrofurfuryl acrylate, 18.5 g 4-hydroxybutyl acrylate and 250 mL toluene. The solution was degassed by purging argon for 30 minutes. Then, 1.0 g of AIBN initiator was added, and the mixture was purged with argon for an additional 10 minutes. The flask was immersed in an 80 °C oil bath and a reflux condenser with an argon inlet attached. The mixture was heated under argon for 16 hours. The reaction was cooled and precipitated with 1.2 L of cold MTBE, and the precipitated product, a sticky polymer, was collected and dried under vacuum. Typical yields are 85-95%.

[0093] The dried polymer was dissolved in dry DMF (200 mL, about 0.5 g / mL) and treated with 0.84 mL of triethylamine and 3.0 mL of ethyl acrylate isocyanate. The mixture was heated to 45°C for 5 hours. The polymer was precipitated with 1.2 L of cold MTBE, washed with 2 x 200 mL of MTBE, and dried under high vacu...

Embodiment 2

[0095] Preparation of liquid primer solution

[0096] In a suitable container, 6.75 g of the polymer of Example 1 was dissolved in 45.0 mL of propylene glycol monomethyl ether acetate. Then, 0.34 g of Pluronic L-81 surfactant, 135 mg of benzophenone and 135 mg of 1-hydroxycyclohexyl phenyl ketone were added. Shake for 30 minutes to achieve complete dissolution, resulting in a clear, homogeneous solution.

Embodiment 3

[0098] Coating microcatheter with primer solution

[0099] A 12" long (0.027" outer diameter) microcatheter segment with an outer surface composed of Grilamid L25 was prepared for coating by first inserting a tight-fitting stainless steel mandrel into the hollow lumen and then wiping the outer surface with acetone. cover. The microcatheter sections were then plasma treated with argon plasma (365 seem, 300 watts, 500 mtorr) followed by oxygen plasma (120 seem, 150 watts, 400 mtorr). The liquid primer formulation prepared in Example 2 was transferred to a glass tube (12" long, 0.22" internal diameter) with a plugged bottom. The microcatheter segments were then placed into the coating solution in the glass tube and left for 5 minutes. The microcatheter segment was taken out and immediately passed through ultraviolet radiation (254nmλ, 1.3J / cm 2 UV dose) cured within 2 minutes to polymerize the primer onto the Grilamid substrate.

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Abstract

Lubricating or blood compatible coatings for medical devices are described.

Description

[0001] related application [0002] This application claims priority to U.S. Provisional Patent Application No. 62 / 879,287, filed July 26, 2019, which is hereby incorporated by reference in its entirety. technical field [0003] Coatings for medical devices and methods of applying these coatings are described herein. Background technique [0004] Catheters and microcatheters are tubular devices used for diagnostic and therapeutic endovascular interventions. One purpose of catheters is to maintain long-term vascular access, for example to allow blood to be drawn or to deliver drugs into the bloodstream. Catheters are often formed from thermoplastic polymers with high friction. These high friction forces make vessel navigation difficult. In addition, prolonged blood exposure can lead to thrombosis, protein adsorption, and platelet activation. It would be useful and beneficial to provide coated catheters or microcatheters with lubricious coatings as described herein. Con...

Claims

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Application Information

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IPC IPC(8): A61L29/08A61L31/14B05D5/00
CPCA61B5/150992A61L29/085A61L2400/10A61L2420/08C08L33/14A61L29/14A61L29/049A61M25/0045
Inventor 格雷戈里·M·克鲁斯史蒂夫·普洛特金彼得·瓦赛克
Owner MICROVENTION INC
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