Pogostemon cablin suppository, preparation method and application

A technology of patchouli suppositories and patchouli, applied in suppository delivery, antifungal agents, pharmaceutical formulations, etc., can solve the problem that patchouli extract cannot fully exert vaginitis, achieve product quality control, and ensure clinical efficacy , Guaranteed curative effect

Pending Publication Date: 2022-04-01
CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to provide a patchouli suppository for the problem that the patchouli extract cannot fully exert its therapeutic effect on vaginitis in the prior art. Firstly, the active ingredient content in the patchouli extract is limited , establish the relationship between patchouli extract and bacterial type, and then use suppositories to ensure the effect and absorption of drugs in the vagina, so that the suppository has a good effect on the treatment of vaginitis

Method used

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  • Pogostemon cablin suppository, preparation method and application
  • Pogostemon cablin suppository, preparation method and application
  • Pogostemon cablin suppository, preparation method and application

Examples

Experimental program
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Effect test

Embodiment 1

[0031] Extraction and Content Determination of Patchouli Extract

[0032] The raw material is selected from patchouli decoction pieces that have not been crushed and infiltrated, and are extracted by water-distillation and steam method. The specific extraction method is as follows:

[0033] In step 1, the decoction pieces of patchouli are not crushed and infiltrated, and the extraction method is adopted by the water separation steam method, and the extraction time is 8 hours, and the extraction rate is the best.

[0034] In step 2, after the extraction is completed, the content of bucchiol (mg / g) and patchouli ketone (mg / g) in the extract are determined by gas chromatography.

[0035] The test results of the content of patchouli alcohol and patchouli ketone in different batches of patchouli extract are as follows,

[0036] Table 1 Determination of different batches of patchouli extract

[0037]

[0038] The patchouli oil contains not less than 30% of pothole alcohol, not...

Embodiment 2

[0040] 1) Prescription

[0041] The prescription composition of 1000 patchouli suppositories (2.0g / grain) is shown in Table 1, and the medicine content of patchouli suppository is 5%, and the ratio of auxiliary material is polyethylene glycol 4000: polyoxyl stearate (40) Esters: polyethylene glycol 400 = 6:3:4.

[0042] Table 2 The prescription composition of 1000 patchouli suppositories

[0043] Raw materials Mass (1000 capsules) Patchouli Extract 100g polyethylene glycol 4000 877g Polyoxyl(40) Stearate 438g polyethylene glycol 400 585g

[0044] 2) The preparation process is as follows

[0045] S1 Ingredients:

[0046] Weigh the ingredients according to the prescription, and take 5kg as the pilot batch.

[0047] S2 matrix melting

[0048] Take 2192g of PEG4000 (solid) and 1096g of polyoxyl (40) stearate (solid) into the emulsification tank in turn, set the lower limit of the temperature of the emulsification tank to 70°C, and the ...

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Abstract

The invention relates to the technical field of pogostemon cablin pharmaceutical compositions, in particular to a pogostemon cablin suppository, a preparation method and application. The weight content of patchouli alcohol in a patchouli extract of the patchouli suppository is 30% or above, the weight content of patchouli ketone is 10% or above, the total weight content of patchouli alcohol and patchouli ketone is 50% or above, and the weight content of the patchouli extract in the patchouli suppository is 5%. And the auxiliary material comprises the following materials: polyethylene glycol 4000, polyoxyl (40) stearate and polyethylene glycol 400 in a ratio of 6: 3: 4. Experimental results prove that the suppository prepared from the extract is more suitable for treatment of vaginitis, especially treatment of vaginitis caused by staphylococcus aureus, escherichia coli, gardnerella vaginalis, candida krusei or candida albicans.

Description

technical field [0001] The invention relates to the technical field of patchouli medicinal compositions, in particular to a patchouli suppository, a preparation method and application. Background technique [0002] The medicinal material of patchouli comes from the dry aerial part of Pogostemon cablin (Blanco) Benth., a plant of the genus Patchouli (Labiatae). It is the key medicine for aromatherapy and dampness. "Compendium of Materia Medica" records: Huoxiang has a clear and fragrant air, so its taste is pungent and its air is slightly warm. "Compendium of Materia Medica" says: The taste is thin and the air is strong, it can rise or fall, and it is yang. "Fu Qingzhu's Women's Section: Leukorrhagia": The husband's leukorrhagia is all dampness. Traditional Chinese medicine believes that the etiology and pathogenesis of vaginitis ("leukorrhagia") is mainly "dampness". Therefore, patchouli can be used to aromatize turbidity and relieve evil spirits, and play a therapeutic r...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/02A61K36/532A61K47/10A61K47/14A61P15/02A61P31/04A61P31/10
CPCY02A50/30
Inventor 彭成熊亮谢晓芳周勤梅彭芙
Owner CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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