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Preparation method of temperature-sensitive gel type medical dressing based on fabric

A technology of temperature-sensitive gel and fabric, applied in medical science, bandages, absorbent pads, etc., can solve problems such as influence and bad

Pending Publication Date: 2022-04-12
SUZHOU UNIV +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

During the construction of the drug delivery system, it can be carried out by changing the temperature and pH value, changing organic solvents, cross-linking agents, additives, emulsifiers, etc., but it may have adverse effects on the human body

Method used

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  • Preparation method of temperature-sensitive gel type medical dressing based on fabric
  • Preparation method of temperature-sensitive gel type medical dressing based on fabric
  • Preparation method of temperature-sensitive gel type medical dressing based on fabric

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0061] Weigh chitosan powders of different masses (50mg, 75mg, 100mg, 125mg) and dissolve them in Hcl solution, stir them evenly with a magnetic stirrer to obtain clear and transparent chitosan solutions with different concentrations; dissolve sodium glycerophosphate in deionized In water, until it is completely dissolved, drop it into the chitosan solution drop by drop, stir while adding, and adjust the pH of the solution to different values. The ready-to-use chitosan / sodium glycerophosphate solution can be stored in a low-temperature environment, and if it is gelled, it can be transferred to a 37°C body box environment.

[0062] Test the gelation time of CS / GP by glass bottle inversion method: divide the sample into small glass bottles, place them in a constant temperature incubator environment at 37°C, rotate the small glass bottles every 1min, when the flow rate in the glass bottles The time required for the gel solution to turn into a gel solid that no longer flows is rec...

Embodiment 2

[0083] Dissolve chitosan powder in dilute hydrochloric acid solution and stir with a magnetic stirrer until the chitosan is completely dissolved and becomes colorless, transparent and slightly viscous. Then take sodium glycerophosphate and dissolve it in deionized water, drop it into the chitosan solution, stir while dropping, and adjust the pH of the solution to 7.15. Then weigh 0.01%, 0.025%, and 0.04% genipin powders of the total solution mass, dissolve them in 50% ethanol solution, drop them into the above-mentioned CS / GP aqueous solution drop by drop, stir while adding, and make them mix uniform. Seal the solutions of the above groups completely and place them in a body box at 37°C until they gel, that is, CGG gel.

[0084] It should be noted that the determination of the drug standard concentration curve can be based on the UV spectrophotometric test method for acetaminophen in the "Chinese Pharmacopoeia", weigh 10 mg of acetaminophen and dissolve it in a small amount o...

Embodiment 3

[0120] Preparation of gel-type medical dressing: Use the impregnation method to arrange the temperature-sensitive gel on the silk fabric. First, soak the silk fabric of an appropriate size in the gel solution under low temperature conditions, and wait until the surface is completely soaked and the gel solution cannot penetrate further. , Squeeze out the excess air bubbles, and then place it in the body box at the target temperature (37°C), and use the stimulation of temperature to realize the sol-gel transition of the gel solution on the surface of the fabric.

[0121] Preparation of drug-loaded thermosensitive gel medical dressing: Weigh a certain mass of acetaminophen drug and dissolve it in the above gel solution to make it evenly dispersed. The drug concentration ρ can be obtained by the ratio of the drug mass to the total solution mass. Satin silk fabric washed, cut to size, dried and weighed M 1 , dipped in the drug-loaded gel solution, repeatedly dipped and pressed, too...

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Abstract

The invention discloses a preparation method of a temperature-sensitive gel type medical dressing based on fabric, which comprises the following steps: S1, dissolving chitosan in a hydrochloric acid solution, and stirring to obtain a chitosan solution; dissolving sodium glycerophosphate in deionized water, and adding the solution into the chitosan solution to obtain a chitosan / sodium glycerophosphate solution; s2, dissolving genipin in an ethanol solution, and adding the chitosan / sodium glycerophosphate solution to obtain a genipin modified chitosan temperature-sensitive gel solution; and S3, dissolving an acetaminophen drug in the genipin modified chitosan temperature-sensitive gel solution, dipping the fabric in the drug-loaded gel solution until the gel solution is uniformly dispersed inside and outside the fabric, sealing the fabric dipped with the gel solution in a container, and putting the fabric in a target temperature environment for gelation, the temperature-sensitive gel is subjected to cross-linking modification, the characteristic of solution-gel transformation of the temperature-sensitive gel is utilized, the fabric is conveniently, quickly and uniformly finished, and the temperature-sensitive gel has the potential of large-scale preparation.

Description

technical field [0001] The invention relates to the field of biological medicine, in particular to a preparation method of a fabric-based temperature-sensitive gel-type medical dressing. Background technique [0002] For commonly seen diseases such as fever and cold, the traditional treatment methods are mainly intravenous drugs and oral drugs. Among them, subcutaneous intravenous administration often brings pain and fear to patients; while oral administration, after the drug enters the human body, it will quickly dissolve into the blood, resulting in a rapid increase in the concentration of the drug in the blood in a short period of time. If you do not continue to take the medicine after a period of time, the concentration of the medicine in the blood will decrease rapidly, and the therapeutic effect will not be achieved. Moreover, many drugs have a gastrointestinal first-pass effect, and taking too much will have an impact on people's health. [0003] At present, the mos...

Claims

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Application Information

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IPC IPC(8): A61L15/28A61L15/42A61L15/44A61L15/40A61L15/20
Inventor 陈宇岳乔娜林红张骜张德锁赵小雯张庆军
Owner SUZHOU UNIV
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