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Piezoelectric nanocomposite and preparation method thereof, and 3D printing bone repair scaffold with piezoelectricity and in-vivo tracing capability

A nanocomposite material and bone printing technology, which is applied in the field of 3D printing bone repair scaffold materials, can solve the problems of increasing trauma and pain of patients

Active Publication Date: 2022-05-03
FOSHAN HOSPITAL OF TCM +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

PVDF does not degrade in vivo, which requires a second operation on the patient, which undoubtedly increases the trauma and pain of the patient

Method used

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  • Piezoelectric nanocomposite and preparation method thereof, and 3D printing bone repair scaffold with piezoelectricity and in-vivo tracing capability
  • Piezoelectric nanocomposite and preparation method thereof, and 3D printing bone repair scaffold with piezoelectricity and in-vivo tracing capability
  • Piezoelectric nanocomposite and preparation method thereof, and 3D printing bone repair scaffold with piezoelectricity and in-vivo tracing capability

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preparation example Construction

[0081] The present invention also provides a method for preparing the piezoelectric nanocomposite described in the above technical solution, comprising the following steps:

[0082] a) subjecting the titanium source compound, the europium source compound and the barium source compound to a hydrothermal reaction to obtain Eu-doped barium titanate nanoparticles;

[0083] b) After mixing the Eu-doped barium titanate nanoparticles, β-TCP and binder obtained in the above steps, sintering to obtain Eu-BTO / β-TCP composite material;

[0084] c) Polarizing the Eu-BTO / β-TCP composite material under a direct current electric field to obtain a piezoelectric nanocomposite material.

[0085] In the present invention, the sintering temperature is preferably 1000-1200°C, more preferably 1050-1150°C.

[0086] In the present invention, the sintering time is preferably 2-4 hours, more preferably 2.5-3.5 hours.

[0087] According to the present invention, the titanium source compound, the europ...

Embodiment 1

[0126] (1) Preparation of Eu-BTO nanoparticles:

[0127] Weigh a certain amount of Ti(OC 4 h 9 ) 4 In a beaker, add absolute ethanol, mix thoroughly on a magnetic stirrer, and then add a certain volume ratio (1:1, 1:3, 1:5, 1:7) of ammonia water and deionized water to it dropwise. Mix the solution, add dropwise while stirring, Ti(OC 4 h 9 ) 4 Hydrolysis occurs to form a white sol. Use a constant temperature heating magnetic stirrer, set the temperature at 90°C, and mix Eu(NO 3 ) 3 ·6H 2 O solution and Ba(OH) 2 ·8H 2 The O solution was slowly added into the reaction system in turn, and the solution was fully stirred and mixed evenly under normal temperature and pressure. The mixed solution is put into a high-pressure reactor, the filling degree of the reactor is 40%-80%, the reaction temperature is 150°C, and the reaction time is 720h. After the reaction is completed, open the kettle to neutralize with acid to neutrality, wash with deionized water, and then wash wit...

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Abstract

The invention provides a piezoelectric nano composite material. The piezoelectric nano composite material comprises Eu-doped barium titanate nano particles and a beta-TCP base material. According to the invention, a rare earth element Eu with osteogenesis induction capability and in-vivo CT (Computed Tomography) development tracing capability is doped into a piezoelectric material BTO (Barium Titanate Oxide) to prepare the Eu-doped barium titanate nanoparticles. The material has the piezoelectric property and also has the osteogenesis induction capacity and the CT development tracing capacity, and the defects and the deficiencies of a traditional piezoelectric material are overcome. According to the invention, the rare earth element Eu is doped into the piezoelectric material BTO to obtain the Eu-BTO material, the Eu-BTO material has piezoelectricity and also has a stronger capability of promoting mesenchymal stem cells to differentiate into osteoblasts, and the Eu is doped, so that the stent containing the Eu-BTO material also has a stronger CT (Computed Tomography) developing effect, which is very beneficial to fracture healing condition monitoring.

Description

technical field [0001] The invention belongs to the field of 3D printed bone repair scaffold materials, in particular to a piezoelectric nanocomposite material and a preparation method thereof, and a 3D printed bone repair scaffold with piezoelectricity and in vivo traceability. Background technique [0002] Clinically, the number of patients with bone injuries caused by various diseases and accidents is on the rise year by year. Bone defects resulting from bone damage require filling and repair. Therefore, repairing the defect position requires the use of artificially manufactured bone repair scaffolds. Scaffolds for bone repair should have the following characteristics: in vivo degradability, good cell compatibility, promotion of osteogenesis, in vivo traceability, and suitable pore structure. The body material of the scaffold can be made from some materials that are degradable in vivo and have low cytotoxicity. The osteogenic role imparted to scaffolds is somewhat more...

Claims

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Application Information

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IPC IPC(8): A61L27/12A61L27/50A61L27/56A61L27/02A61L27/04C04B35/468C04B35/447C04B35/626C04B35/622C04B38/00B33Y70/10B33Y10/00B33Y80/00
CPCA61L27/12A61L27/50A61L27/56A61L27/025A61L27/047C04B35/4682C04B35/447C04B35/626C04B35/622C04B38/00B33Y70/10B33Y10/00B33Y80/00A61L2430/02C04B2235/3224C04B2235/5454C04B2235/5445C04B38/0051Y02P10/25
Inventor 徐志强王宇谢韶东章培标罗汉文曾得明
Owner FOSHAN HOSPITAL OF TCM