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Application of geniposide in preparation of medicine for treating psoriasis

A technology for psoriasis and geniposide, which is applied in the application field of medicine, can solve the problems of increased incidence and achieve the effect of improving skin lesions

Pending Publication Date: 2022-05-06
GUANGDONG HOSPITAL OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Biological therapy is generally more effective, however, biological agents can cause infectious diseases (such as tuberculosis, pneumonia, enteritis, sepsis, etc.) and tumors (such as non-melanoma skin cancer, lung cancer, breast cancer, colon cancer, gastric cancer, prostate cancer etc.) significantly increased the incidence of

Method used

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  • Application of geniposide in preparation of medicine for treating psoriasis
  • Application of geniposide in preparation of medicine for treating psoriasis
  • Application of geniposide in preparation of medicine for treating psoriasis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Pharmacodynamic experiment of imiquimod-induced psoriasis model

[0031] Animals and grouping: 12 SPF grade BALB / c mice, male, 8 weeks old, purchased from Guangdong Medical Experimental Animal Center, production license number SCXK (Guangdong) 2013-0002. The experimental animals were kept in the barrier environment animal room of Guangdong Provincial Hospital of Traditional Chinese Medicine. This experiment was approved by the Ethics Committee of Guangdong Provincial Hospital of Traditional Chinese Medicine (NO.2021090). Twelve BALB / c mice were randomly divided into four groups according to body weight: normal group, model group, geniposide group, and leonurin A group, with 3 mice in each group.

[0032] Drugs and reagents: In this experiment, the iridoid components geniposide and motherrubioside A were selected. The batch numbers are S14J10Y79596 and J11GB154353 respectively. They were purchased from Shanghai Yuanye Biotechnology Co., Ltd. and prepared by adding pure ...

Embodiment 2

[0043] Anti-psoriasis efficacy experiment of geniposide

[0044] Animals and grouping: 48 SPF grade BALB / c mice, male, 8 weeks old, were purchased from Guangdong Medical Experimental Animal Center, production license number SCXK (Guangdong) 2013-0002. The experimental animals were kept in the barrier environment animal room of Guangdong Provincial Hospital of Traditional Chinese Medicine, the room temperature was 20-25°C, the relative humidity was 40%-70%, and the light and dark alternated between day and night for 12h / 12h. This experiment was approved by the Ethics Committee of Guangdong Provincial Hospital of Traditional Chinese Medicine (NO.2021090). Forty-eight BALB / c mice were randomly divided into normal group, model group, geniposide low-dose, medium-dose and high-dose groups, and methotrexate group according to body weight, a total of 6 groups with 8 mice in each group.

[0045] Drugs and reagents: methotrexate tablets, 2.50 mg per tablet, Shanghai Xinyi Pharmaceutica...

Embodiment 3

[0073] A tablet for the treatment of psoriasis

[0074] prescription:

[0075]

[0076] Preparation method: Weigh the geniposide raw material drug, lactose and sodium hydroxymethyl starch (75% of the prescription quantity) according to the prescription quantity, mix them, pass through a 120-mesh sieve for 3 times, and mix well. Add an appropriate amount of binder to make a soft material. The soft material is passed through a 18-mesh sieve, and the wet granules are dried in an oven at 50°C for 1 hour. Prescription amount), mix well, compress into tablets, and get ready.

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Abstract

The invention discloses an application of geniposide in preparation of a medicine for treating psoriasis. The geniposide can effectively relieve erythema, scales and thickening of the skin at the skin lesion position of a Babl / c mouse induced by imiquimod and remarkably reduce the PASI score of the psoriasis mouse, and the PASI score of a geniposide high-dose group is slightly superior to that of a positive control drug. The improvement on the basic form of psoriasis mice by medium and high doses of geniposide is superior to that of methotrexate tablets, including the hair glossiness and weight of animals. In the geniposide, high dosage can significantly reduce abnormal increase of the spleen index of psoriasis induced by imiquimod, the geniposide has no significant difference from methotrexate tablets, and the safety is superior to that of methotrexate.

Description

technical field [0001] The invention belongs to the field of medicines, and in particular relates to the application of geniposide in the preparation of medicines for treating psoriasis. Background technique [0002] Psoriasis is a chronic relapsing autoimmune-related skin disease determined by polygenetic inheritance and stimulated by multiple environmental factors. Its appearance is characterized by thickened silver-white scales covered on erythema. The unsightly appearance of psoriasis causes patients to have a strong inferiority complex, which affects their employment and quality of life. Long-term treatment consumption not only brings serious economic and mental burden to patients, but also leads to huge social burden due to high morbidity and long-term treatment. [0003] Modern medicine determines the treatment strategy according to the severity of psoriasis. For mild patients, local treatment is mainly used, for moderate and severe patients, systemic treatment comb...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61P17/06
CPCA61K31/7048A61P17/06
Inventor 卢传坚刘丽娟赵瑞芝吴亚运赵亚
Owner GUANGDONG HOSPITAL OF TRADITIONAL CHINESE MEDICINE
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