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Polyethylene glycol sodium potassium powder and preparation method thereof

A technology of polyethylene glycol sodium potassium powder and polyethylene glycol, which is applied in the field of medicine and biology, can solve the problems of poor fluidity, poor content uniformity, and large difference in loading of the blend, so as to achieve good fluidity and improve fluidity , the effect of reducing the difference in loading

Active Publication Date: 2022-05-06
重庆希尔安药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In view of the deficiencies in the prior art, the present invention proposes a preparation method of polyethylene glycol sodium potassium powder, to solve the polyethylene glycol sodium potassium powder prepared by the existing method, and the polyethylene glycol sodium potassium powder. The content uniformity of sodium bicarbonate, sodium chloride, and potassium chloride is poor. At the same time, the fluidity of the mixture prepared by using the existing preparation method is poor, resulting in large differences in loading volume and affecting the curative effect.

Method used

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  • Polyethylene glycol sodium potassium powder and preparation method thereof
  • Polyethylene glycol sodium potassium powder and preparation method thereof
  • Polyethylene glycol sodium potassium powder and preparation method thereof

Examples

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Embodiment 1

[0035] see figure 1 , a preparation method of polyethylene glycol sodium potassium powder, comprising the following steps:

[0036] Step 1. Preparation of solution I: Add polyethylene glycol 3350 into a hot pot, heat and melt at 60°C to obtain solution I.

[0037] Step 2, preparation of solution II: take sodium chloride, potassium chloride, sodium bicarbonate and sweetener, add 3 times the amount of purified water at a temperature of 60° C., stir to dissolve and clarify, and obtain solution II.

[0038] Step 3, preparation of solution III: adding solution II to solution I, stirring and mixing evenly, stirring for 10 minutes, heating at 60° C. to obtain mixed solution III.

[0039] Step 4, Spray drying: Turn on the spray drying tower fan, set the fan frequency of the spray drying tower fan to 50Hz, let in natural wind, and the natural wind temperature is 25°C, spray solution Ⅲ into the spray tower, adjust the flow rate, and make the spray fine In the fog state, after all spra...

Embodiment 2

[0052] see figure 2 , on the basis of embodiment 1, the difference of the preparation method in the present embodiment and embodiment 1 is as follows:

[0053] A preparation method of polyethylene glycol sodium potassium powder, comprising the following steps:

[0054] Step 1. Prepare solution I: add polyethylene glycol 3350 into a hot pot, heat and melt at a temperature above 60°C to obtain solution I.

[0055] Step 2, preparation of solution II: take sodium chloride, potassium chloride, sodium bicarbonate and sweetener, add 3 times the amount of the temperature to 70 ° C, stir to dissolve and clarify, and obtain solution II.

[0056] Step 3, preparation of solution III: add solution II to solution I, stir and mix evenly for 15 minutes, then heat at 65° C. to obtain mixed solution III.

[0057] Step 4, Spray drying: Turn on the spray drying tower fan, set the fan frequency of the spray drying tower fan to 50HZ, let in natural wind, the natural wind temperature is 20°C, spr...

Embodiment 3

[0062] see image 3 , on the basis of embodiment 1, the difference of the preparation method in the present embodiment and embodiment 1 is as follows:

[0063] A preparation method of polyethylene glycol sodium potassium powder, comprising the following steps:

[0064] Step 1. Prepare solution I: add polyethylene glycol 3350 into a hot pot, heat and melt at a temperature above 60°C to obtain solution I.

[0065] Step 2, preparation of solution II: take sodium chloride, potassium chloride, sodium bicarbonate and sweetener, add 3 times the amount of the temperature to 75 ° C, stir to dissolve and clarify, and obtain solution II.

[0066] Step 3. Prepare solution III: add solution II to solution I, stir and mix evenly for 20 minutes, then heat at 70° C. to obtain mixed solution III.

[0067] Step 4, Spray drying: Turn on the spray drying tower fan, set the fan frequency of the spray drying tower fan to 50HZ, let in natural wind, and the natural wind temperature is 18°C, spray s...

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Abstract

The invention relates to the technical field of medical biology, in particular to a preparation method of polyethylene glycol sodium potassium powder. Comprising the following steps: preparing a solution I: adding polyethylene glycol 3350 into a hot melting pot, and carrying out hot melting to obtain the solution I; preparing a solution II: taking sodium chloride, potassium chloride, sodium bicarbonate and a sweetening agent, adding 3 times of purified water, stirring, dissolving and clarifying to obtain the solution II; preparing a solution III: adding the solution II into the solution I, stirring and heating to obtain a mixed solution III; spray drying: starting a fan of a spray drying tower, feeding natural air, spraying the solution III into the spray tower, starting the fan of the spray drying tower for heating after spraying is completed, and stopping the spray drying tower for discharging; sieving: adding the spray-dried material into a shaking sieve; total mixing: adding a flavoring agent into the sieved material, and mixing to obtain a total mixture of the polyethylene glycol sodium potassium powder. The invention aims to solve the problems that the polyethylene glycol sodium-potassium powder prepared by the existing method is poor in uniformity and poor in total mixture flowability, and the curative effect is influenced.

Description

technical field [0001] The invention relates to the technical field of medicine and biology, in particular to a preparation method of polyethylene glycol sodium potassium powder. Background technique [0002] The main components of polyethylene glycol sodium potassium powder are polyethylene glycol 3350, sodium chloride, potassium chloride and sodium bicarbonate, of which polyethylene glycol 3350 accounts for more than 95% of the prescription, sodium chloride, potassium chloride Sodium chloride and sodium bicarbonate are used in small amounts (4%), therefore, it is difficult to mix sodium chloride, potassium chloride and sodium bicarbonate by directly mixing polyethylene glycol 3350, sodium chloride, potassium chloride and sodium bicarbonate Mix evenly. In industrialized production, unqualified content uniformity of sodium chloride, potassium chloride and sodium bicarbonate often occurs, resulting in unqualified products and great losses. [0003] The raw material of polyet...

Claims

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Application Information

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IPC IPC(8): A61K33/14A61K9/14A61K9/16A61K31/77A61K33/00A61K47/26A61P1/10
CPCA61K31/77A61K33/14A61K33/00A61K47/26A61K9/145A61K9/1623A61P1/10Y02P20/10
Inventor 梅勇罗磊袁开超龙涛粟冲李歆悦杨莉杨旋王丽军陈犁谯志文
Owner 重庆希尔安药业有限公司
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