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Preparation method of injectable hydrogel

A technology for injecting water and hydrogel, which is applied in the field of biomedical engineering, can solve the problems of surrounding tissue damage, inconvenient operation, uneven tissue fit, etc., and achieve good flexibility and elasticity

Active Publication Date: 2022-05-13
HUAZHONG UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] The invention solves the problems in the prior art that the surrounding tissue is damaged by spraying the cross-linking agent, the operation is inconvenient caused by the pre-mixed cross-linking agent, and the formed hydrogel has irregular shape and non-uniform tissue fit.

Method used

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  • Preparation method of injectable hydrogel
  • Preparation method of injectable hydrogel

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Experimental program
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preparation example Construction

[0038] A kind of preparation method of injectable hydrogel of the present invention, comprises the following steps:

[0039] (1) dissolving the calcium salt cross-linking agent in deionized water to obtain a cross-linking agent solution;

[0040] (2) dissolving polyvinyl alcohol into the cross-linking agent solution obtained in step (1), placing it at room temperature after freezing, and obtaining the first hydrogel after melting; or adding bacterial cellulose to the cross-linking agent solution obtained in step (1) In the linking agent solution, the crosslinking agent solution is absorbed by bacterial cellulose to obtain the first hydrogel; this step can store the crosslinking agent uniformly in the first hydrogel, and the first hydrogel Skin-friendly and skin-adhesive properties can wrap and cover the wound well;

[0041] (3) Alginate is added to physiological saline to obtain alginate solution; the first hydrogel obtained in step (2) is pasted on the alginate solution, and...

Embodiment 1

[0048] A method for preparing an injectable hydrogel, comprising the following steps:

[0049] (1) Weigh CaCl according to the mass volume ratio (w / v) of 1%. 2 The powder is dissolved in deionized water and sterilized at high temperature and high pressure to become 1% (1g / 100ml) CaCl 2 solution;

[0050] (2) Weigh 10g of PVA powder in a blue bottle, after high temperature and high pressure sterilization, add 90g of the above 1% CaCl 2 solution, heated with magnetic stirring until completely dissolved to form PVA-CaCl 2 Solution, absorb a certain volume of the above solution and place it in a container of a certain specification, freeze it for a period of time, place it at room temperature, and get PVA-CaCl after melting 2 Hydrogels;

Embodiment 2

[0054] A method for preparing an injectable hydrogel, comprising the following steps:

[0055] (1) Weigh CaCl according to the mass volume ratio (w / v) of 3% 2 Powder dissolved in deionized water, autoclaved to 3% CaCl 2 (3g / 100ml) solution;

[0056] (2) Weigh 10g of PVA powder in a blue bottle, after high temperature and high pressure sterilization, add 90g of the above 3% CaCl 2 solution, heated with magnetic stirring until completely dissolved to form PVA-CaCl 2 Solution, absorb a certain volume of the above solution and place it in a container of a certain specification, freeze it for a period of time, place it at room temperature, and get PVA-CaCl after melting 2 Hydrogels;

[0057] (3) According to the mass volume ratio (w / v) of 0.5% (0.5g / 100ml), take sodium alginate powder and dissolve it in 0.9% physiological saline, and sterilize it with a 0.22 μm filter after fully dissolving to form sodium alginate- 0.9% saline solution;

[0058] (4) if figure 1 As shown, the...

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Abstract

The invention relates to a preparation method of injectable hydrogel, and belongs to the field of biomedical engineering. Dissolving a calcium salt cross-linking agent in deionized water to obtain a cross-linking agent solution; dissolving polyvinyl alcohol into a cross-linking agent solution, freezing and taking out to obtain first hydrogel; or adding the bacterial cellulose into the cross-linking agent solution, and swelling the cross-linking agent solution by the bacterial cellulose to obtain first hydrogel; adding alginate into normal saline to obtain an alginate solution; first hydrogel is attached to the alginate solution, alginate is cross-linked through a cross-linking agent in the first hydrogel, the first hydrogel is taken down, and the injectable hydrogel is obtained. According to the invention, the problem that a wound is quickly closed when tissue defects occur in an operation or an accidental process is solved.

Description

technical field [0001] The invention belongs to the field of biomedical engineering, and more specifically relates to a preparation method of an injectable hydrogel. Background technique [0002] Polymer hydrogel is an ideal carrier and extracellular matrix. Among them, injectable hydrogels have attracted much attention as implant materials due to their low damage and shape plasticity during use. Doctors often remove all kinds of tissues during the resection operation. The resected tissues are irregular in shape and often accompanied by bleeding or tissue collapse. How to timely seal the wound during the operation and observe it at any time is an urgent problem to be solved. At the same time , after a large area of ​​necrotic tissue is removed, how to quickly repair the damaged tissue and restore function is also a problem that needs to be solved. [0003] Stem cell transplantation is a promising therapeutic approach for tissue regeneration, but its poor differentiation an...

Claims

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Application Information

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IPC IPC(8): A61L26/00
CPCA61L26/0014A61L26/0023A61L26/008A61L26/0004A61L26/0057A61L26/0061A61L26/0066A61L2400/06A61L2300/414A61L2300/30C08L29/04C08L1/02C08L5/04
Inventor 杨光郑瑞珠石志军龙开鑫
Owner HUAZHONG UNIV OF SCI & TECH
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