Preparation method of acetyl glycyrrhetinic acid

A technology of glycyrrhetinic acid and monoammonium glycyrrhizinate, which is applied in the fields of steroids and organic chemistry, can solve the problems of large organic solvent loss, cumbersome preparation process, and high cost. low cost effect

Pending Publication Date: 2022-05-17
XINJIANG FUWO PHARMA
View PDF2 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this method has the disadvantages of cumbersome preparation process, high energy consumption, large

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Preparation method of acetyl glycyrrhetinic acid
  • Preparation method of acetyl glycyrrhetinic acid
  • Preparation method of acetyl glycyrrhetinic acid

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0033] Example 1

[0034] A preparation method of acetylglycyrrhetinic acid is prepared by the following steps:

[0035] Take 100kg of dried glycyrrhizic acid monoammonium salt mother liquor, add 450kg of glacial acetic acid with a concentration of 85%, stir and dissolve to obtain a mixed solution, then add 20kg of sulfuric acid to the mixed solution, heat up to 90 ° C, and react for 1.5h to carry out hydrolysis and acetylation reaction, After the above-mentioned reaction was completed, the temperature of the reaction system was reduced to 40 ℃ by feeding cooling water, filtered, washed successively with the glacial acetic acid of 65% with 100kg concentration, washed to pH 5 with water again, and dried at 85 ℃ to obtain acetylglycyrrhetinic acid 10.8 kg.

Example Embodiment

[0036] Example 2

[0037] A preparation method of acetylglycyrrhetinic acid is prepared by the following steps:

[0038] Take 120kg of dry glycyrrhizic acid monoammonium salt mother liquor, add 550kg of glacial acetic acid with a concentration of 85%, stir and dissolve to obtain a mixed solution, then add 30kg of sulfuric acid to the mixed solution, heat up to 95°C, and react for 1.5h to carry out hydrolysis and acetylation. After the above-mentioned reaction was completed, the temperature of the reaction system was reduced to 40 ℃ by feeding cooling water, filtered, washed successively with the glacial acetic acid of 65% with 120kg concentration, washed to pH 5.5 with water again, and dried at 85 ℃ to obtain acetylglycyrrhetinic acid 12.24 kg.

Example Embodiment

[0039] Example 3

[0040] A preparation method of acetylglycyrrhetinic acid is prepared by the following steps:

[0041] Take 220kg of the dry product of glycyrrhizic acid monoammonium salt mother liquor, add 1000kg of glacial acetic acid with a concentration of 85%, stir and dissolve to obtain a mixed solution, then add 60kg of sulfuric acid to the mixed solution, heat up to 98 ℃, and react for 1.5h to carry out hydrolysis and acetylation reaction, After the above-mentioned reaction is completed, the temperature of the reaction system is reduced to 40 ℃ by passing into cooling water, filtered, washed successively with 250kg concentration of glacial acetic acid that is 65%, washed to pH 6 with water again, and dried at 85 ℃ to obtain acetylglycyrrhetinic acid 22.5 kg.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention provides a preparation method of acetyl glycyrrhetinic acid, and belongs to the technical field of acetyl glycyrrhetinic acid preparation. According to the method, by-products in the production process of mono-ammonium glycyrrhizinate are adopted as raw materials, firstly, a dried mono-ammonium glycyrrhizinate mother liquor product is dissolved with a hydrophilic organic solvent, and then the acetyl glycyrrhetinic acid is obtained through catalytic hydrolysis and acetylation with mineral acid. The preparation method of the acetyl glycyrrhetinic acid provided by the invention has the advantages that the process is simplified, the process is easy to control, the production cost is low, the product is purer, the quality of the glycyrrhetinic acid synthesized by the acetyl glycyrrhetinic acid prepared by the method meets EP standard requirements of EU, and the yield is obviously higher than that of the prior art.

Description

technical field [0001] The invention relates to the technical field of preparation of acetylglycyrrhetinic acid, in particular to a preparation method of acetylglycyrrhetinic acid. Background technique [0002] Licorice is a commonly used traditional Chinese medicine, and its main active ingredient, glycyrrhizic acid, has corticotropic hormone-like effects and can be used for detoxification, anti-inflammation, antitussive, and anti-tumor. The aglycone of glycyrrhizic acid is glycyrrhetinic acid. Studies have found that in the human body, glycyrrhizic acid is hydrolyzed by gastric acid or decomposed by β-glucuronidase in the liver to form glycyrrhetinic acid, and then absorbed into the blood through the small intestine, so it finally exerts its medicinal effect. The effect is essentially the effect of glycyrrhetinic acid. Modern studies have shown that glycyrrhetinic acid is superior to glycyrrhizic acid in anti-inflammatory, anti-ulcer, anti-allergic, anti-viral, hypolipide...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): C07J63/00
CPCC07J63/008
Inventor 陈振鸿安晨光王耀红
Owner XINJIANG FUWO PHARMA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap