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Slow-release enrofloxacin suspension and preparation method thereof

A slow-release enrofloxacin and enrofloxacin technology, which is applied in pharmaceutical formulation, liquid delivery, emulsion delivery, etc., can solve the problems of low drug content, short half-life, and large irritation in emulsions, and improve bioavailability The effect of high degree, simple preparation method and long acting time

Pending Publication Date: 2022-05-31
四川永诺生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because enrofloxacin has poor water solubility, bitter taste, strong irritation and easy decomposition, it greatly limits its clinical application in veterinary medicine. At present, commonly used enrofloxacin preparations mainly include emulsion, solid granule and injection, etc., and Ordinary injections have a short half-life and rapid elimination in the body, requiring multiple administrations, which is time-consuming and laborious; emulsions have low drug content and require a large number of multiple administrations; solid granules have low bioavailability, which is not conducive to large-scale administration
Due to the bitter taste of enrofloxacin, the oral solutions and soluble powders currently on the market are all used on chickens, and less used on pigs

Method used

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  • Slow-release enrofloxacin suspension and preparation method thereof
  • Slow-release enrofloxacin suspension and preparation method thereof
  • Slow-release enrofloxacin suspension and preparation method thereof

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preparation example Construction

[0029] The present invention also discloses a method for preparing a sustained-release enrofloxacin suspension, comprising the following steps:

[0030] Step 1: Weigh the following components according to the mass percentage: enrofloxacin 3%-8%, methylcellulose 0.8%-1.0%, glycerin 10%-15%, citric acid 0.8%-1.2%, sodium benzoate 0.02%-0.10%, the remaining amount is purified water, and the total content of the above mass percentage is 100%;

[0031] Step 2, the methylcellulose swelling treatment: the weighed methylcellulose into the beaker, add the sustained release enrofloxacin suspension total volume of 30% of the purified water, stirred on the magnetic stirrer for 3-4h, swelling and standby;

[0032] Step 3, the enrofloxacin dispersion treatment: take the weighed enrofloxacin grinding for 10-20min, grind finely, add an appropriate amount of purified water to disperse;

[0033] Step 4, in the dispersed Enrofloxacin added 5 drops of 2mol / L sodium hydroxide solution to dissolve, a...

Embodiment 1

[0037] A sustained-release enrofloxacin suspension consisting of the following components according to the mass percentage content: enrofloxacin 5%, methylcellulose content 0.85%, glycerol content 14%, citric acid content 0.8%, sodium benzoate 0.06%, residual water, the total mass percentage content of the above is 100%.

[0038] The preparation method of the above-mentioned sustained-release enrofloxacin suspension is as follows:

[0039] Step 1: Weigh each component according to the above mass percentage;

[0040] Step 2, the methylcellulose swelling treatment: the weighed methylcellulose into the beaker, add the sustained release enrofloxacin suspension of 30% of the total volume of purified water, stirred on the magnetic stirrer for 3.5h, swelling and standby;

[0041] Step 3: Disperse enrofloxacin: take the weighed enrofloxacin and grind it for 15 minutes, grind it finely, and add an appropriate amount of purified water to disperse;

[0042] Step 4, in the dispersed enrofloxa...

Embodiment 2

[0046] A sustained-release enrofloxacin suspension consisting of the following components according to the mass percentage content: enrofloxacin 3%, methylcellulose 0.8%, glycerol 15%, citric acid 0.8%, sodium benzoate 0.10%, the remaining amount is purified water, the total mass percentage content of the above is 100%.

[0047] The preparation method of the above-mentioned sustained-release enrofloxacin suspension is as follows:

[0048] Step 1: Weigh each component according to the above mass percentage;

[0049] Step 2, the methylcellulose swelling treatment: the weighed methylcellulose into the beaker, add the sustained release enrofloxacin suspension of 30% of the total volume of purified water, stirred on the magnetic stirrer for 3h, swelling and standby;

[0050] Step 3, the enrofloxacin dispersion treatment: take the weighed enrofloxacin grinding for 20min, grind fine, add an appropriate amount of purified water to disperse;

[0051] Step 4, in the dispersed enrofloxacin a...

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Abstract

The invention discloses a slow-release enrofloxacin suspension and a preparation method thereof, the slow-release enrofloxacin suspension comprises the following components by mass: 3%-8% of enrofloxacin, 0.8%-1.0% of methyl cellulose, 10%-15% of glycerin, 0.8%-1.2% of citric acid, 0.02%-0.10% of sodium benzoate, and the balance of purified water, and the total mass percentage content is 100%. The suspension is prepared in a fine crystallization mode, enrofloxacin is dispersed in a colloidal solution of a suspending aid in an extremely fine microcrystal form, the stability of the suspension is remarkably improved, glycerol is used as a sweetening agent, the palatability of the product is improved, the enrofloxacin suspension is good in absorption, long in acting time and simple in preparation method, the bioavailability of the enrofloxacin suspension can be improved, and the enrofloxacin suspension can be applied to the field of oral administration. And the product can play a more efficient role.

Description

Technical field [0001] The present invention belongs to the field of veterinary drug technology, specifically, relates to a sustained-release enrofloxacin suspension and a method of preparation thereof. Background [0002] Fluoroquinolones are more and more widely used in veterinary medicine in China, but the development and research of their preparations are still relatively backward, and most of them are common dosage forms such as injections, powders, oral solutions and a small number of ointments, and there have been no reports of long-acting preparations. Enrofloxacin liposomes, sustained-release agents and pouring agents have been reported abroad. Common preparations of veterinary fluoroquinolones often need to be administered twice a day, especially injections, and frequent administration not only consumes manpower and time, but also causes stress responses in animals. In order to delay drug absorption, prolong the maintenance time of effective blood concentrations, and th...

Claims

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Application Information

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IPC IPC(8): A61K9/10A61K47/38A61K47/10A61K47/12A61K31/496A61P31/04
CPCA61K9/10A61K9/0053A61K47/38A61K47/10A61K47/12A61K31/496A61P31/04Y02A50/30
Inventor 李江王榆鑫曾月赵素梅韩雯静陈静月谭宜菊张伟舒刚符华林
Owner 四川永诺生物科技有限公司
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