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Composition for relieving acute alcoholic liver injury as well as preparation method and application thereof

A technology for alcoholic liver injury and composition, which is applied in the field of compositions for relieving acute alcoholic liver injury and its preparation, and can solve problems such as necrosis, poisoning, fibrosis and the like

Pending Publication Date: 2022-06-03
上海朗泰凯尔生物技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, acetaldehyde has obvious toxic effects on liver cells, leading to degeneration, necrosis and fibrosis of liver cells.

Method used

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  • Composition for relieving acute alcoholic liver injury as well as preparation method and application thereof
  • Composition for relieving acute alcoholic liver injury as well as preparation method and application thereof
  • Composition for relieving acute alcoholic liver injury as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] The composition for relieving acute alcoholic liver injury in this embodiment includes: active polysaccharides, natural active compounds and probiotics, the active polysaccharides include kylin cabbage active polysaccharide, wolfberry active polysaccharide, hawthorn active polysaccharide, the kylin cabbage active polysaccharide, wolfberry The active polysaccharide and hawthorn active polysaccharide are respectively unicornis polysaccharide, wolfberry polysaccharide and hawthorn polysaccharide, which are separated by dialysis membranes with different pore sizes, and obtained by low temperature freeze-drying. Natural active compounds are active phenolic compounds isolated from pineapples, including structural formula pineapple polyphenol-1, the structural formula is pineapple polyphenol-2, the structural formula is of pineapple polyphenol-3. Probiotics include Streptococcus thermophilus lyophilized powder, Lactobacillus acidophilus lyophilized powder, Lactobacillus pl...

Embodiment 2

[0115] The difference between this example and Example 1 is that this example selects the active polysaccharide of 10-15kD kylin cabbage, the active polysaccharide of Lycium barbarum 10-15kD, the active polysaccharide of hawthorn of 10-15kD, and Streptococcus thermophilus freeze-dried powder, The mass ratio of Lactobacillus acidophilus lyophilized powder, Lactobacillus plantarum lyophilized powder, Lactobacillus casei lyophilized powder, pineapple polyphenol-1, pineapple polyphenol-2, pineapple polyphenol-3 is 1:10:10:1 :1:1:1:1:1:1.

Embodiment 3

[0117] The difference between this example and Example 1 is that the present embodiment selects the active polysaccharide of 5-10kD kylin cabbage and the active polysaccharide of Lycium barbarum 10-15kD, the active polysaccharide of hawthorn of 5-10kD, Streptococcus thermophilus freeze-dried powder, The mass ratio of Lactobacillus acidophilus lyophilized powder, Lactobacillus plantarum lyophilized powder, Lactobacillus casei lyophilized powder, pineapple polyphenol-1, pineapple polyphenol-2, pineapple polyphenol-3 is 1:1:1:0.01 :0.01:0.01:0.01:0.001:0.001:0.001.

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Abstract

The invention belongs to the technical field of biological medicine preparation, and particularly relates to a composition for relieving acute alcoholic liver injury and a preparation method and application thereof. Comprising active polysaccharide, a natural active compound and probiotics, and the mass ratio of the active polysaccharide to the probiotics to the natural active compound is (3-21): (0.04-4): (0.003-3). Natural active micromolecules, eucheuma polysaccharide, lycium barbarum polysaccharide and hawthorn polysaccharide optimal alcoholic liver injury resisting active ingredients are obtained through a simple activity tracking method, and then the optimal alcoholic liver injury resisting active ingredients are optimally combined and compounded with freeze-dried powder of streptococcus thermophilus, lactobacillus acidophilus, lactobacillus plantarum and lactobacillus casei with alcoholic liver injury resisting activity. The active polysaccharide, natural active micromolecule and probiotic composition has very remarkable activity when being used for treating acute liver injury caused by alcohol, and has no side effect.

Description

technical field [0001] The invention belongs to the technical field of biological medicine preparation, and particularly relates to a composition for relieving acute alcoholic liver injury and a preparation method and application thereof. Background technique [0002] Alcohol is mainly metabolized in the liver, so long-term heavy drinking can seriously damage the liver. After alcohol enters the liver, it is first oxidized to acetaldehyde, then oxidized to acetic acid, and finally converted to carbon dioxide and water and excreted. Acetaldehyde has obvious toxic effects on hepatocytes, leading to degeneration, necrosis and fibrosis of hepatocytes. With the increasing incidence of alcoholic liver injury, liver diseases such as viral hepatitis, cirrhosis and even liver cancer have also increased. Among them, one-time heavy drinking can cause acute alcoholic liver injury. [0003] Studies have shown that traditional Chinese medicine compound preparations have a good protectiv...

Claims

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Application Information

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IPC IPC(8): A61K35/747A61K35/744A61K31/715A61K31/12A61P1/16A23L33/105A23L33/125A23L33/135
CPCA61K35/747A61K35/744A61K31/715A61K31/12A61P1/16A23L33/105A23L33/125A23L33/135A23V2002/00A61K2300/00A23V2200/3204A23V2200/334A23V2250/2132A23V2250/51
Inventor 刘杰宗睿栗伟马龙鹏张玉波罗丹王文雅郑曼
Owner 上海朗泰凯尔生物技术有限公司
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