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Sleep-aiding liposome-coated compound amino acid composition and preparation method thereof

A compound amino acid, liposome technology, applied in the directions of liposome delivery, drug combination, medical preparations of inactive ingredients, etc., can solve the problem that the drug cannot be fully absorbed, and achieve the effect of rapid absorption

Active Publication Date: 2022-06-03
纽柏抗衰老国际医生集团(广州)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The present application provides a composition and preparation method of liposome-encapsulated compound amino acids to help sleep, so as to solve the technical problem that the drug cannot be fully absorbed in the prior art

Method used

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  • Sleep-aiding liposome-coated compound amino acid composition and preparation method thereof
  • Sleep-aiding liposome-coated compound amino acid composition and preparation method thereof

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preparation example Construction

[0051] In an embodiment of the present application, as figure 1 As shown, a preparation method of a sleep-promoting liposome-encapsulated composite amino acid composition is provided, the method comprising:

[0052] S1. obtain each raw material of described composition;

[0053] S2. adding the compound amino acid and the whey protein degrading polypeptide into a solvent, and performing the first mixing to obtain an activated amino acid solution;

[0054] S3. obtain liposome;

[0055] S4. process and dilute the liposome permeabilization to obtain a liposome solution;

[0056] S5. Pour the activated amino acid solution into the liposome solution, add a complexing agent at the same time, and then perform a second mixing, then filter and dry to obtain a liposome-encapsulated complex amino acid composition.

[0057] As an optional embodiment, the first mixing is stirring mixing, the stirring speed of the first mixing is 2000r / min~2500r / min, and the time of the first mixing is 15...

Embodiment 1

[0071] A sleep-promoting liposome-encapsulated complex amino acid composition, in terms of mass fraction, the composition comprises: liposome: 40%, complex amino acid: 25%, whey protein degrading polypeptide: 20% and complexing agent: 15%.

[0072] In terms of mass fraction, the complex amino acids include: gamma-aminobutyric acid: 26%, tryptophan: 20%, serine: 16%, arginine: 17%, ornithine: 15% and glycine: 6%.

[0073] In terms of mass fraction, the complexing agent includes: sodium hyaluronate: 50% and yeast fermentation broth: 50%.

[0074] The molecular weight of sodium hyaluronate is 400 kDa.

[0075] The liposomes included lecithin, cholesterol and vitamin E, and the mass ratio of lecithin, cholesterol and vitamin E was 8:0.8:0.4.

[0076] like figure 1 and figure 2 As shown, a preparation method of a sleep-promoting liposome-encapsulated composite amino acid composition, comprising:

[0077] S1. obtain each raw material of the composition;

[0078] S2. adding th...

Embodiment 2

[0091] Comparing Embodiment 2 and Embodiment 1, the difference between Embodiment 2 and Embodiment 1 is:

[0092] A sleep-promoting liposome-encapsulated complex amino acid composition, calculated in mass fraction, comprising: liposome: 35%, complex amino acid: 20%, whey protein degrading polypeptide: 30% and complexing agent: 15%.

[0093] In terms of mass fraction, the complex amino acids include: gamma-aminobutyric acid: 25%, tryptophan: 15%, serine: 20%, arginine: 17%, ornithine: 18%, glycine: 5%.

[0094] In terms of mass fraction, the complexing agent includes: sodium hyaluronate: 40%, yeast fermentation broth: 60%.

[0095] The molecular weight of sodium hyaluronate is 10 kDa.

[0096] The liposomes include lecithin, cholesterol and vitamin E, and the mass ratio of lecithin, cholesterol and vitamin E is 5:2:0.5.

[0097] The first mixing is stirring mixing, the stirring speed of the first mixing is 2000r / min, and the time of the first mixing is 15min;

[0098] The s...

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Abstract

The invention relates to the field of amino acid compositions, in particular to a sleep-aiding lipidosome-coated compound amino acid composition and a preparation method thereof, the composition comprises lipidosome, compound amino acid, whey protein degradation polypeptide and a complexing agent; the method comprises the following steps: obtaining raw materials of the composition; adding the compound amino acid and the whey protein degradation polypeptide into a solvent, and performing first mixing to obtain an activated amino acid solution; the liposome is obtained; performing membrane rupture treatment on the lipidosome and diluting to obtain a lipidosome solution; pouring the activated amino acid solution into the liposome solution, adding a complexing agent at the same time, and then carrying out second mixing, filtering and drying to obtain a composition with composite amino acid wrapped by liposome; the liposome serves as a carrier, the compound amino acid and the whey protein degradation polypeptide serve as active ingredients, the active ingredients and the carrier are fully fused and bonded through the complexing agent, rapid absorption of medicine ingredients is achieved, and meanwhile the composition can adjust the emotion of the human body and improve the sleep quality of the human body.

Description

technical field [0001] The present application relates to the field of amino acid compositions, in particular to a composition and preparation method of a sleep-promoting liposome-encapsulated compound amino acid. Background technique [0002] In the environment of the 21st century, food for stress relief and sleep aid has become a hot spot of concern for people with anxiety. Due to social pressure, work pressure, study pressure, life pressure, etc., anxiety is everywhere. In recent years, anxiety has become a The characteristics of new modern people and sleep problems caused by anxiety have also become one of the hot topics in recent years. [0003] At present, most of the drugs or foods for sleep problems focus on improving sleep, such as melatonin. Although melatonin is harmless to the human body, because the metabolic cycle of melatonin is 48 hours, the unmetabolized melatonin will It leads to the disorder of the human body's biological clock, and the long-term use of m...

Claims

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Application Information

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IPC IPC(8): A61K38/17A61K9/127A61K47/24A61K47/28A61K47/22A61K47/36A61K47/46A61P25/20A61P25/00A23L33/115A23L33/175A23L33/18A23L33/10A61K31/197A61K31/405A61K31/198
CPCA61K38/1709A61K31/197A61K31/405A61K31/198A61K9/1277A61K47/24A61K47/28A61K47/22A61K47/36A61K47/46A61P25/20A61P25/00A23L33/115A23L33/175A23L33/18A23L33/10A23V2002/00A61K2300/00A23V2250/06A23V2250/065A23V2250/0606A23V2250/0642A23V2250/0622A23V2250/0636A23V2250/038A23V2250/55A23V2250/712A23V2200/322Y02A50/30
Inventor 唐斌王会堂王苏明
Owner 纽柏抗衰老国际医生集团(广州)有限公司
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